Q3T0U1
Gene name |
MESD (MESDC2) |
Protein name |
LRP chaperone MESD |
Names |
LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:514610 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3T0U1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3T0U1-F1 | Predicted | AlphaFoldDB |
39 variants for Q3T0U1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs462592484 | 4 | S>A | No | EVA | |
| rs462592484 | 4 | S>P | No | EVA | |
| rs462304853 | 6 | W>G | No | EVA | |
| rs440648869 | 6 | W>L | No | EVA | |
| rs462304853 | 6 | W>R | No | EVA | |
| rs451703074 | 7 | A>G | No | EVA | |
| rs473446524 | 7 | A>P | No | EVA | |
| rs133961120 | 8 | R>P | No | EVA | |
| rs437828468 | 9 | A>G | No | EVA | |
| rs457365301 | 9 | A>P | No | EVA | |
| rs448959732 | 11 | V>A | No | EVA | |
| rs448959732 | 11 | V>E | No | EVA | |
| rs448959732 | 11 | V>G | No | EVA | |
| rs467519431 | 11 | V>M | No | EVA | |
| rs466838865 | 12 | I>V | No | EVA | |
| rs444884870 | 14 | L>F | No | EVA | |
| rs477970858 | 14 | L>P | No | EVA | |
| rs462493180 | 18 | D>E | No | EVA | |
| rs450530723 | 22 | L>P | No | EVA | |
| rs462447834 | 23 | L>M | No | EVA | |
| rs458381493 | 26 | P>T | No | EVA | |
| rs475974425 | 29 | A>D | No | EVA | |
| rs439668403 | 29 | A>P | No | EVA | |
| rs473860250 | 42 | A>T | No | EVA | |
| rs433895997 | 43 | T>N | No | EVA | |
| rs455473813 | 43 | T>P | No | EVA | |
| rs469110549 | 50 | K>N | No | EVA | |
| rs450469224 | 51 | K>N | No | EVA | |
| rs480207734 | 54 | R>G | No | EVA | |
| rs447157407 | 60 | D>Y | No | EVA | |
| rs480177696 | 61 | M>I | No | EVA | |
| rs439924825 | 73 | D>G | No | EVA | |
| rs800912827 | 111 | T>M | No | EVA | |
| rs440596793 | 117 | T>P | No | EVA | |
| rs479916160 | 121 | N>T | No | EVA | |
| rs470795357 | 131 | T>P | No | EVA | |
| rs468904217 | 164 | Y>F | No | EVA | |
| rs454273667 | 214 | L>P | No | EVA | |
| rs3423488152 | 217 | R>W | No | EVA |
No associated diseases with Q3T0U1
No regional properties for Q3T0U1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q3T0U1 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| low-density lipoprotein particle receptor binding | Binding to a low-density lipoprotein receptor. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| ossification | The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. |
| phagocytosis | A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. |
| positive regulation of skeletal muscle acetylcholine-gated channel clustering | Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering. |
| protein folding | The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. |
| protein localization to cell surface | A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5ZKK4 | mesd | LRP chaperone MESD | Gallus gallus (Chicken) | PR |
| Q14696 | MESD | LRP chaperone MESD | Homo sapiens (Human) | PR |
| Q5U2R7 | Mesd | LRP chaperone MESD | Rattus norvegicus (Rat) | PR |
| A1L243 | mesd | LRP chaperone MESD | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAASGWARAA | VIFLCACDLL | LLLLLPPRAF | ATEGPAETPG | EATPPPRKKK | KDIRDYNDAD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MARLLEQWEK | DDDIEEGDLP | EHKRPSAPID | FSQIDPGKPE | SILKMTKKGK | TLMMFVTVSG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NPTEKETEEI | TSLWQGSLFN | ANYDVQRFIV | GSDRAIFMLR | DGGYAWEIKD | FLVSQDRCAD |
| 190 | 200 | 210 | 220 | 230 | |
| VTLEGQVYPG | KGGGSKEKNQ | TKQEKGKKKK | ERDLKPRASK | EDNRAGSKKE | EL |