Q5U2R7

PR
Gene name
Mesd (Mesdc2)
Protein name
LRP chaperone MESD
Names
LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:308796
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

165-224 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5U2R7

Entry ID Method Resolution Chain Position Source
AF-Q5U2R7-F1 Predicted AlphaFoldDB

No variants for Q5U2R7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5U2R7

No associated diseases with Q5U2R7

No regional properties for Q5U2R7

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5U2R7

Functions

Description
EC Number
Subcellular Localization
  • Endoplasmic reticulum
  • Released from apoptotic cells and shed photoreceptor outer segments
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
low-density lipoprotein particle receptor binding Binding to a low-density lipoprotein receptor.

6 GO annotations of biological process

Name Definition
ossification The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
phagocytosis A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles.
positive regulation of skeletal muscle acetylcholine-gated channel clustering Any process that activates or increases the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein localization to cell surface A process in which a protein is transported to, or maintained in, a location within the external part of the cell wall and/or plasma membrane.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3T0U1 MESD LRP chaperone MESD Bos taurus (Bovine) PR
Q5ZKK4 mesd LRP chaperone MESD Gallus gallus (Chicken) PR
Q14696 MESD LRP chaperone MESD Homo sapiens (Human) PR
A1L243 mesd LRP chaperone MESD Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MAASSWLRAV LLFLCASDLL LLSPPEAYAT DTPGEAITPP RKKKDIRDYN DADMARLLEQ
70 80 90 100 110 120
WEKDDDIEEG DLPEHKRPSA PIDFSKLDPG KPESILKMTK KGKTLMMFVT ISGNPTEKET
130 140 150 160 170 180
EEITSLWQGS LFNANYDVQR FIVGSDRAIF MLRDGSYAWE IKDFLVNQDR CAEVTLEGQM
190 200 210 220
YPGKGGGSKE KNKTKPEKGK KKEGDPKPRA SKEDNRAGSR REDL