Q5ZKH3

PR
Gene name
EED (RCJMB04_10n8)
Protein name
Polycomb protein EED
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:426381
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-62 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZKH3

Entry ID Method Resolution Chain Position Source
AF-Q5ZKH3-F1 Predicted AlphaFoldDB

No variants for Q5ZKH3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZKH3

No associated diseases with Q5ZKH3

2 regional properties for Q5ZKH3

Type Name Position InterPro Accession
domain Nascent polypeptide-associated complex NAC domain 20 - 84 IPR002715
domain Nascent polypeptide-associated complex subunit alpha-like, UBA domain 140 - 177 IPR044034

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
ESC/E(Z) complex A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone methylation The modification of histones by addition of methyl groups.
negative regulation of transcription by RNA polymerase II Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q3SZ25 EED Polycomb protein EED Bos taurus (Bovine) PR
O75530 EED Polycomb protein EED Homo sapiens (Human) PR
Q921E6 Eed Polycomb protein EED Mus musculus (Mouse) PR
Q28DT7 eed Polycomb protein eed Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
Q566T0 eed Polycomb protein eed Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MSERGEAPAA AASAGAGGEM PAKKQKLSSD ENSNPGDLSG DENDDAVSIE SGTNTERPDT
70 80 90 100 110 120
PTNTPNAPGR KSWGKGKWKS KKCKYSFKCV NSLKEDHGQP LFGVQFNWHS KEGDPLVFAT
130 140 150 160 170 180
VGSNRVTLYE CHSQGEIRLL QSYVDADADE NFYTCAWTYD SNTSHPLLAV AGSRGIIRII
190 200 210 220 230 240
NPITMQCIKH YVGHGNAINE LKFHPRDPNL LLSVSKDHAL RLWNIQTDTL VAIFGGVEGH
250 260 270 280 290 300
RDEVLSADYD LLGEKIMSCG MDHSLKLWRI NSKRMINAIK ESYEYNPNKT NRPFISQKIH
310 320 330 340 350 360
FPDFSTRDIH RNYVDCVRWL GDLILSKSCE NAIVCWKPGK MEDDIDKIKP SESNVTILGR
370 380 390 400 410 420
FDYSQCDIWY MRFSMDFWQK MLALGNQVGK LYVWDLEIED PHKAKCTTLT HPKCVAAIRQ
430 440
TSFSRDSSIL IAVCDDASIW RWDRLR