AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-93 (Predicted disordered autoinhibitory region) PR

1-93 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q3SZ25-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs469292650	4	R>S	No	EVA
rs446047049	6	V>G	No	EVA
rs481486201	15	M>I	No	EVA
rs446981904	15	M>K	No	EVA
rs461570316	16	P>A	No	EVA
rs461570316	16	P>T	No	EVA
rs459250095	27	E>G	No	EVA
rs439042201	28	N>I	No	EVA
rs470622562	28	N>K	No	EVA
rs459947421	30	N>I	No	EVA
rs474490946	36	D>Y	No	EVA
rs454617020	38	N>T	No	EVA
rs438438853	48	T>S	No	EVA
rs479622326	49	N>D	No	EVA
rs468487897	116	V>L	No	EVA
rs446057224	142	D>G	No	EVA
rs463063907	142	D>N	No	EVA
rs798136478	151	A>V	No	EVA
rs462588505	177	P>T	No	EVA
rs440658859	243	D>G	No	EVA
rs472253133	247	L>F	No	EVA
rs476106478	258	H>L	No	EVA
rs441742275	258	H>Y	No	EVA
rs456223928	261	K>R	No	EVA
rs461221241	288	P>T	No	EVA
rs452511588	300	S>A	No	EVA
rs456904194	378	A>T	No	EVA
rs443216581	381	N>I	No	EVA
rs443216581	381	N>S	No	EVA
rs471669910	383	V>G	No	EVA
rs465791759	384	G>A	No	EVA
rs434727951	384	G>C	No	EVA
rs435632653	385	K>Q	No	EVA
rs450033761	386	L>P	No	EVA
rs478262070	390	D>A	No	EVA
rs464817600	395	D>Y	No	EVA
rs468889309	414	R>P	No	EVA
rs483213820	421	D>Y	No	EVA
rs464660462	433	S>G	No	EVA

Type	Name	Position	InterPro Accession
repeat	WD40 repeat	81 - 125	IPR001680-1
repeat	WD40 repeat	131 - 176	IPR001680-2
repeat	WD40 repeat	179 - 273	IPR001680-3
repeat	WD40 repeat	295 - 332	IPR001680-4
repeat	WD40 repeat	397 - 438	IPR001680-5
conserved_site	WD40 repeat, conserved site	206 - 220	IPR019775

		Description
EC Number
Subcellular Localization	Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ESC/E(Z) complex	A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.

Name	Definition
enzyme activator activity	Binds to and increases the activity of an enzyme.
histone methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
identical protein binding	Binding to an identical protein or proteins.
transcription corepressor binding	Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.

Name	Definition
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q5ZKH3	EED	Polycomb protein EED	Gallus gallus (Chicken)	PR
O75530	EED	Polycomb protein EED	Homo sapiens (Human)	PR
Q921E6	Eed	Polycomb protein EED	Mus musculus (Mouse)	PR
Q28DT7	eed	Polycomb protein eed	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q566T0	eed	Polycomb protein eed	Danio rerio (Zebrafish) (Brachydanio rerio)	PR