Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q566T0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q566T0-F1 | Predicted | AlphaFoldDB |
No variants for Q566T0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q566T0 | |||||
No associated diseases with Q566T0
6 regional properties for Q566T0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 83 - 127 | IPR001680-1 |
| repeat | WD40 repeat | 133 - 178 | IPR001680-2 |
| repeat | WD40 repeat | 181 - 275 | IPR001680-3 |
| repeat | WD40 repeat | 297 - 334 | IPR001680-4 |
| repeat | WD40 repeat | 401 - 440 | IPR001680-5 |
| conserved_site | WD40 repeat, conserved site | 208 - 222 | IPR019775 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| ESC/E(Z) complex | A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| chromatin organization | The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA. |
| histone methylation | The modification of histones by addition of methyl groups. |
| negative regulation of transcription by RNA polymerase II | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3SZ25 | EED | Polycomb protein EED | Bos taurus (Bovine) | PR |
| Q5ZKH3 | EED | Polycomb protein EED | Gallus gallus (Chicken) | PR |
| O75530 | EED | Polycomb protein EED | Homo sapiens (Human) | PR |
| Q921E6 | Eed | Polycomb protein EED | Mus musculus (Mouse) | PR |
| Q28DT7 | eed | Polycomb protein eed | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKMRRKMSEP | HGEAGNEMPN | KKQKLSSDEN | SNPDLSGDDN | DDAVSVESGT | HPERPDTPTN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TASAPGRKSW | GKGKWKSKKC | KYSFKCVNSL | KEDHGQPLFG | VQFNWHSKEG | DPLVFATVGS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| NRVTLYECHS | QGEIRLLQSY | VDADADENFY | TCAWTFDCSS | SHPLLAVAGS | RGIIRIINHI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TMQCVKHYVG | HGNAINELKF | HPRDPNLLLS | VSKDHALRLW | NIQTDTLVAI | FGGVEGHRDE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VLSADFDLLG | EKIMSCGMDH | SLKLWRLDSE | RLQRAIRGSY | EYNPSKTNRP | FVSQKIHFPD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FSTRDIHRNY | VDCVRWLGDL | ILSKSCENAI | VCWKPGRMED | DIDRIKPNES | NVTILGRFDY |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SQCDIWYMRF | SMDFWQKMLA | LGNQVGKLYV | WDLEVEDPHK | AKCTTLTLPR | CTSAIRQTSF |
| 430 | 440 | ||||
| SRDSSILIAV | CDDASIWRWD | RLR |