AiPD: Autoinhibited Protein Database

O75530

Gene name	EED
Protein name	Polycomb protein EED
Names	hEED, Embryonic ectoderm development protein, WD protein associating with integrin cytoplasmic tails 1, WAIT-1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:8726
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-92 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-92 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

69 structures for O75530

Entry ID	Method	Resolution	Chain	Position	Source
3IIW	X-ray	180 A	A	77-441	PDB
3IIY	X-ray	265 A	A	77-441	PDB
3IJ0	X-ray	245 A	A	77-441	PDB
3IJ1	X-ray	210 A	A	77-441	PDB
3IJC	X-ray	195 A	A	77-441	PDB
3JPX	X-ray	205 A	A	40-441	PDB
3JZG	X-ray	210 A	A	40-441	PDB
3JZH	X-ray	205 A	A	40-441	PDB
3JZN	X-ray	260 A	A	76-441	PDB
3K26	X-ray	158 A	A	76-441	PDB
3K27	X-ray	176 A	A	76-441	PDB
4W2R	X-ray	281 A	E/F	81-441	PDB
4X3E	X-ray	230 A	A	77-441	PDB
5GSA	X-ray	249 A	A/B	76-441	PDB
5H13	X-ray	190 A	A	76-441	PDB
5H14	X-ray	190 A	A/B	76-441	PDB
5H15	X-ray	227 A	A/B	76-441	PDB
5H17	X-ray	230 A	A	76-441	PDB
5H19	X-ray	190 A	A	76-441	PDB
5H24	X-ray	250 A	A/B	76-441	PDB
5H25	X-ray	288 A	A/B	76-441	PDB
5HYN	X-ray	295 A	B/G/L/R	77-441	PDB
5IJ7	X-ray	262 A	E/F	81-441	PDB
5IJ8	X-ray	299 A	E/F	81-441	PDB
5K0M	X-ray	183 A	A	77-441	PDB
5LS6	X-ray	347 A	B/E/H/K	77-441	PDB
5TTW	X-ray	174 A	A/C	76-441	PDB
5U5H	X-ray	180 A	A	76-441	PDB
5U5K	X-ray	233 A	A	76-441	PDB
5U5T	X-ray	160 A	A/B	76-441	PDB
5U62	X-ray	190 A	A/B	76-441	PDB
5U69	X-ray	128 A	A	77-441	PDB
5U6D	X-ray	164 A	A	77-441	PDB
5U8A	X-ray	145 A	A	77-441	PDB
5U8F	X-ray	134 A	A	77-441	PDB
5WG6	X-ray	390 A	B/D	2-441	PDB
5WP3	X-ray	255 A	A	75-441	PDB
5WUK	X-ray	203 A	A	76-441	PDB
6B3W	X-ray	305 A	E/F	81-441	PDB
6C23	EM	390 A	L	1-441	PDB
6C24	EM	350 A	L	1-441	PDB
6LO2	X-ray	221 A	A/B	76-441	PDB
6SFB	X-ray	152 A	A/B	76-441	PDB
6SFC	X-ray	200 A	A/B	76-441	PDB
6U4Y	X-ray	291 A	D/E/F	78-441	PDB
6V3X	X-ray	170 A	A	75-441	PDB
6V3Y	X-ray	163 A	A	81-439	PDB
6W7F	X-ray	220 A	A	77-441	PDB
6W7G	X-ray	185 A	A	77-441	PDB
6WKR	EM	350 A	L	1-441	PDB
6YVI	X-ray	226 A	A/B	76-441	PDB
6YVJ	X-ray	184 A	A/B	76-441	PDB
7KSO	EM	390 A	B	1-441	PDB
7KSR	EM	410 A	B	1-441	PDB
7KTP	EM	480 A	B	1-441	PDB
7KXT	X-ray	215 A	A/B	40-441	PDB
7MSB	X-ray	190 A	A	77-441	PDB
7MSD	X-ray	220 A	A	77-441	PDB
7P3C	X-ray	161 A	A/B	76-441	PDB
7P3G	X-ray	239 A	A/B	76-441	PDB
7P3J	X-ray	193 A	A/B	76-441	PDB
7QJG	X-ray	180 A	A/B	77-441	PDB
7QJU	X-ray	180 A	A/B	77-441	PDB
7QK4	X-ray	160 A	A	77-441	PDB
7SI4	X-ray	190 A	A	40-441	PDB
7SI5	X-ray	175 A	A	40-441	PDB
7TD5	X-ray	299 A	B/G	77-441	PDB
8FYH	EM	340 A	C/I	1-441	PDB
AF-O75530-F1	Predicted				AlphaFoldDB

168 variants for O75530

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
RCV001049094 rs773510026	3	E>D	Cohen-Gibson syndrome [ClinVar]	Yes	ClinVar dbSNP
RCV001309293 rs766472086	4	R>K	Cohen-Gibson syndrome [ClinVar]	Yes	ClinVar dbSNP
RCV001258333 rs1945363239	17	A>V	Cohen-Gibson syndrome [ClinVar]	Yes	ClinVar dbSNP
rs1459981515 RCV001197531	25	S>G	Cohen-Gibson syndrome [ClinVar]	Yes	ClinVar dbSNP
RCV000981790 rs149126431 CA6216345	50	T>P	Cohen-Gibson syndrome [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
rs1565692818 RCV000699978 CA382003896	146	N>K	Cohen-Gibson syndrome [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs147440081 RCV001247531 CA6216434	178	I>V	Cohen-Gibson syndrome [ClinVar]	Yes	ClinGen ClinVar ESP ExAC TOPMed dbSNP gnomAD
VAR_079255	194	N>S	COGIS [UniProt]	Yes	UniProt
VAR_079256	236	R>G	COGIS [UniProt]	Yes	UniProt
rs1131692176 VAR_078316 RCV000495685 CA382004532	236	R>T	Cohen-Gibson syndrome COGIS; decreased trimethylation of 'Lys-27' of histone H3; no effect on interaction with EZH2 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
VAR_079257 CA382004703 RCV000494950 rs1131692174	258	H>Y	Cohen-Gibson syndrome COGIS [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt Ensembl dbSNP
RCV000983832 rs367891435 CA6216508	274	I>V	Cohen-Gibson syndrome [ClinVar]	Yes	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
RCV000816549 CA6216520 rs781731485	294	I>V	Cohen-Gibson syndrome [ClinVar]	Yes	ClinGen ClinVar ExAC dbSNP gnomAD
RCV000495365 rs1131692175 CA382005025 VAR_079258 COSM3720451	302	R>G	Variant assessed as Somatic; impact. Cohen-Gibson syndrome haematopoietic_and_lymphoid_tissue COGIS [NCI-TCGA, ClinVar, Cosmic, UniProt]	Yes	ClinGen cosmic curated ClinVar UniProt Ensembl NCI-TCGA dbSNP
RCV000495739 VAR_078317 rs1131692173 CA382005030	302	R>S	Cohen-Gibson syndrome COGIS; decreased trimethylation of 'Lys-27' of histone H3 [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt TOPMed dbSNP
rs1565706229 CA382007711 RCV000708568	366	M>T	Cohen-Gibson syndrome [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
RCV000988621 CA382007922 rs1593776227	378	A>V	Cohen-Gibson syndrome [ClinVar]	Yes	ClinGen ClinVar Ensembl dbSNP
rs780894846	10	P>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
rs1186239339	21	Q>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	34	S>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6216340 COSM932707 rs138343311	41	A>T	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs780620361 CA6216341	41	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1158957036 CA382061303	44	I>M		No	ClinGen gnomAD
CA382061301 rs1420554958	44	I>T		No	ClinGen TOPMed gnomAD
rs749513327 CA6216342	44	I>V		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	45	E>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382061313 rs1325758414	46	S>G		No	ClinGen TOPMed
rs769007751 CA6216343	47	G>V		No	ClinGen ExAC TOPMed gnomAD
CA382061327 rs1593721068	48	T>S		No	ClinGen Ensembl
rs772008343 CA6216346	50	T>I		No	ClinGen ExAC gnomAD
rs772993565 CA6216347	52	R>C	Variant assessed as Somatic; 4.666e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1306469162 CA382061353	52	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	54	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1240504562 CA382061373	55	T>I		No	ClinGen TOPMed gnomAD
TCGA novel	55	T>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382061374 rs1240504562	55	T>R		No	ClinGen TOPMed gnomAD
CA225537281 rs890695718	58	N>D		No	ClinGen Ensembl
TCGA novel	58	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382061400 rs1343373792	59	T>M		No	ClinGen gnomAD
rs753700468 CA6216350	60	P>A		No	ClinGen ExAC gnomAD
TCGA novel	61	N>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	61	N>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759130955 CA6216351	62	A>T		No	ClinGen ExAC TOPMed gnomAD
CA6216353 rs752209808	64	G>E		No	ClinGen ExAC gnomAD
TCGA novel	66	K>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1353115591 CA382061498	73	W>C		No	ClinGen gnomAD
TCGA novel	73	W>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1464396199 CA382061491	73	W>R		No	ClinGen gnomAD
CA6216357 rs756747245	75	S>L		No	ClinGen ExAC gnomAD
CA382061539 rs1467825675	79	K>T		No	ClinGen gnomAD
rs1402767573 CA382061577	84	C>Y		No	ClinGen gnomAD
CA382061613 rs1401637097	89	K>T		No	ClinGen gnomAD
rs1197226177 CA382061638	91	D>N		No	ClinGen TOPMed
rs751115357 CA6216375	93	N>D		No	ClinGen ExAC gnomAD
TCGA novel	98	G>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	99	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1263775594 CA382061720	102	N>D		No	ClinGen gnomAD
rs1266388674 CA382061746	105	S>G		No	ClinGen TOPMed
CA6216378 rs754218053	109	D>A		No	ClinGen ExAC gnomAD
rs1565689787 CA382061825	116	V>A		No	ClinGen Ensembl
rs1221175263 CA382061842	119	N>D		No	ClinGen TOPMed
rs1482435543 CA382003738	125	E>V		No	ClinGen TOPMed
CA382003751 rs1417875292	127	H>Y		No	ClinGen gnomAD
rs1225330920 CA382003769	129	Q>H		No	ClinGen TOPMed
CA6216406 rs183646722	133	R>Q		No	ClinGen 1000Genomes ExAC gnomAD
rs745786094 COSM467511 CA6216405	133	R>W	kidney [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
CA225323962 rs367879986	136	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs1042646641 CA225323986	137	S>F		No	ClinGen TOPMed
rs776117763 CA6216410	139	V>L		No	ClinGen ExAC TOPMed gnomAD
rs776117763 CA225324001	139	V>M		No	ClinGen ExAC TOPMed gnomAD
CA382003906 rs1200013330	148	Y>H		No	ClinGen gnomAD
CA6216423 rs757539279	149	T>A		No	ClinGen ExAC gnomAD
CA6216425 rs750525883	151	A>V		No	ClinGen ExAC gnomAD
TCGA novel	152	W>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1434243467 CA382003950	154	Y>C		No	ClinGen gnomAD
TCGA novel	155	D>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs141323002 CA6216428	158	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA225324663 rs141323002	158	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA382003990 rs1565692901	160	H>Y		No	ClinGen Ensembl
CA382003999 rs1377492603	161	P>A		No	ClinGen TOPMed
CA382004020 rs1434590457	165	V>I		No	ClinGen gnomAD
TCGA novel	169	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1346705627 CA382004065	172	I>V		No	ClinGen gnomAD
rs771855344 CA6216432	174	I>M		No	ClinGen ExAC gnomAD
rs1369539791 CA382004082	174	I>T		No	ClinGen TOPMed gnomAD
CA382004079 rs1451703523	174	I>V		No	ClinGen TOPMed
CA382004090 rs1277436586	175	I>M		No	ClinGen gnomAD
TCGA novel	181	Q>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6216457 rs374964622	193	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	201	R>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	201	R>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs767913799 CA6216458	204	N>D		No	ClinGen ExAC TOPMed gnomAD
CA225325343 rs767913799	204	N>H		No	ClinGen ExAC TOPMed gnomAD
CA382004305 rs1339838230	204	N>S		No	ClinGen TOPMed gnomAD
CA6216460 rs974144	207	L>M		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	212	D>Y	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1324041105 CA382004436	221	Q>R		No	ClinGen gnomAD
rs919112787 CA225328966	222	T>M		No	ClinGen Ensembl
CA382004440 rs1196865201	222	T>S		No	ClinGen gnomAD
TCGA novel	225	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs759722952 CA6216482	232	V>I		No	ClinGen ExAC
rs1407096240 CA382004625	247	L>F		No	ClinGen gnomAD
rs1388170340 CA382004622	247	L>S		No	ClinGen gnomAD
TCGA novel	250	K>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	251	I>*	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1340382867 CA382004715	260	L>V		No	ClinGen gnomAD
rs775716311 CA6216505	264	R>K		No	ClinGen ExAC gnomAD
CA6216506 rs374311051	266	N>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA225330029 rs905981541	270	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
COSM932713 CA6216507 rs763956385	271	M>I	endometrium [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
TCGA novel	272	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs938759887 CA225330040	272	N>S		No	ClinGen TOPMed gnomAD
CA382004808 rs1358750337	273	A>T		No	ClinGen gnomAD
rs1292309172 CA382004826	275	K>N		No	ClinGen gnomAD
rs1487912547 CA382004850	279	D>N		No	ClinGen gnomAD
rs1199068566 CA382004866	281	N>H		No	ClinGen TOPMed
rs1593754647 CA382004884	283	N>S		No	ClinGen Ensembl
rs771185794 CA6216519	290	I>T		No	ClinGen ExAC gnomAD
CA225331212 rs977513717	292	Q>K		No	ClinGen Ensembl
TCGA novel	294	I>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6216521 rs746020326	295	H>Y		No	ClinGen ExAC gnomAD
CA6216522 rs770152825	296	F>L		No	ClinGen ExAC gnomAD
rs1301151502 CA382005107	313	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1408450238 COSM87721 CA382005133	317	D>N	Variant assessed as Somatic; 0.0 impact. pancreas endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1343385276 CA382006907	326	N>T		No	ClinGen gnomAD
rs970497140 CA225336766	327	A>S		No	ClinGen TOPMed gnomAD
CA225336772 rs947096920	328	I>V		No	ClinGen TOPMed
rs1432214115 CA382006942	329	V>M		No	ClinGen gnomAD
TCGA novel	334	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA382007051 rs1480171332	335	K>M		No	ClinGen TOPMed
TCGA novel	338	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1593774854 CA382007126	339	D>Y		No	ClinGen Ensembl
CA382007150 rs747972868	340	I>R		No	ClinGen ExAC TOPMed gnomAD
rs747972868 CA6216555	340	I>T		No	ClinGen ExAC TOPMed gnomAD
CA6216554 rs774560012	340	I>V		No	ClinGen ExAC TOPMed gnomAD
rs779621699 CA225336817	343	I>M		No	ClinGen Ensembl
CA382007237 rs1216386093	345	P>A		No	ClinGen gnomAD
CA382007244 rs1207890235	345	P>R		No	ClinGen TOPMed
rs772015033 CA6216556	346	S>N		No	ClinGen ExAC gnomAD
CA382007339 rs1165886207	350	V>G		No	ClinGen TOPMed gnomAD
rs760494356 CA6216558	352	I>V		No	ClinGen ExAC gnomAD
rs1460129527 CA382007404	353	L>V		No	ClinGen gnomAD
CA382007576 rs1444960146	360	Q>H		No	ClinGen gnomAD
TCGA novel	363	I>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	364	W>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1311812688 CA382007769	370	M>T		No	ClinGen gnomAD
rs759299377 CA6216561	370	M>V		No	ClinGen ExAC TOPMed gnomAD
CA382007825 rs1405614156	373	W>C		No	ClinGen gnomAD
CA382007989 rs1593776239	383	V>F		No	ClinGen Ensembl
TCGA novel	388	V>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs762517406 CA6216581	392	E>K		No	ClinGen ExAC gnomAD
CA6216582 rs763742808	395	D>E		No	ClinGen ExAC gnomAD
rs1263896263 CA382008191	397	H>R		No	ClinGen gnomAD
CA6216583 rs750950743	399	A>V		No	ClinGen ExAC TOPMed gnomAD
CA382008260 rs1289428544	405	T>S		No	ClinGen TOPMed
rs760021454 CA6216625	405	T>S		No	ClinGen ExAC gnomAD
rs199562674 CA6216628	410	G>A		No	ClinGen 1000Genomes ExAC gnomAD
CA382008294 rs1485511920	410	G>S		No	ClinGen gnomAD
TCGA novel	413	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6216629 rs764331181	413	I>V		No	ClinGen ExAC gnomAD
CA382008340 rs1447185281	417	S>T		No	ClinGen gnomAD
TCGA novel	423	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA225337745 rs951387529	426	I>M		No	ClinGen TOPMed gnomAD
CA382008407 rs1565707121	426	I>V		No	ClinGen Ensembl
rs1326013174 CA382008450	432	A>D		No	ClinGen gnomAD
CA225337750 rs1005649993	440	L>R		No	ClinGen Ensembl
CA6216632 rs767548896 COSM932716	441	R>*	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
CA382008528 COSM932717 rs1363668348	441	R>Q	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD

No associated diseases with O75530

5 regional properties for O75530

Type	Name	Position	InterPro Accession
domain	ABC transporter-like, ATP-binding domain	27 - 249	IPR003439
domain	AAA+ ATPase domain	55 - 226	IPR003593
domain	ABC transporter, teichoic acids export TagH-like	8 - 231	IPR015860
conserved_site	ABC transporter-like, conserved site	150 - 164	IPR017871
domain	LysM domain	403 - 448	IPR018392

Functions

		Description
EC Number
Subcellular Localization	Nucleus Chromosome	Transiently colocalizes with XIST at inactive X chromosomes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
ESC/E(Z) complex	A multimeric protein complex that can methylate lysine-27 and lysine-9 residues of histone H3. In Drosophila the core subunits of the complex include ESC, E(Z), CAF1 (NURF-55) and SU(Z)12. In mammals the core subunits of the complex include EED, EZH2, SUZ12 and RBBP4.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

5 GO annotations of molecular function

Name	Definition
chromatin binding	Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
enzyme activator activity	Binds to and increases the activity of an enzyme.
histone methyltransferase activity	Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.
identical protein binding	Binding to an identical protein or proteins.
transcription corepressor binding	Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.

4 GO annotations of biological process

Name	Definition
chromatin organization	The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
negative regulation of DNA-templated transcription	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of transcription by RNA polymerase II	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
spinal cord development	The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.

5 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q3SZ25	EED	Polycomb protein EED	Bos taurus (Bovine)	PR
Q5ZKH3	EED	Polycomb protein EED	Gallus gallus (Chicken)	PR
Q921E6	Eed	Polycomb protein EED	Mus musculus (Mouse)	PR
Q28DT7	eed	Polycomb protein eed	Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)	PR
Q566T0	eed	Polycomb protein eed	Danio rerio (Zebrafish) (Brachydanio rerio)	PR

10	20	30	40	50	60
MSEREVSTAP	AGTDMPAAKK	QKLSSDENSN	PDLSGDENDD	AVSIESGTNT	ERPDTPTNTP
70	80	90	100	110	120
NAPGRKSWGK	GKWKSKKCKY	SFKCVNSLKE	DHNQPLFGVQ	FNWHSKEGDP	LVFATVGSNR
130	140	150	160	170	180
VTLYECHSQG	EIRLLQSYVD	ADADENFYTC	AWTYDSNTSH	PLLAVAGSRG	IIRIINPITM
190	200	210	220	230	240
QCIKHYVGHG	NAINELKFHP	RDPNLLLSVS	KDHALRLWNI	QTDTLVAIFG	GVEGHRDEVL
250	260	270	280	290	300
SADYDLLGEK	IMSCGMDHSL	KLWRINSKRM	MNAIKESYDY	NPNKTNRPFI	SQKIHFPDFS
310	320	330	340	350	360
TRDIHRNYVD	CVRWLGDLIL	SKSCENAIVC	WKPGKMEDDI	DKIKPSESNV	TILGRFDYSQ
370	380	390	400	410	420
CDIWYMRFSM	DFWQKMLALG	NQVGKLYVWD	LEVEDPHKAK	CTTLTHHKCG	AAIRQTSFSR
430	440
DSSILIAVCD	DASIWRWDRL	R