Q5TM70
Gene name |
FLOT1 |
Protein name |
Flotillin-1 |
Names |
|
Species |
Macaca mulatta (Rhesus macaque) |
KEGG Pathway |
mcc:714175 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5TM70
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5TM70-F1 | Predicted | AlphaFoldDB |
No variants for Q5TM70
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5TM70 | |||||
No associated diseases with Q5TM70
3 regional properties for Q5TM70
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Immunoglobulin subtype | 42 - 115 | IPR003599-1 |
| domain | Immunoglobulin subtype | 123 - 201 | IPR003599-2 |
| domain | Immunoglobulin-like domain | 34 - 111 | IPR007110 |
Functions
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasmic vesicle | A vesicle found in the cytoplasm of a cell. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| flotillin complex | A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae. |
| melanosome | A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. |
| membrane raft | Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| positive regulation of cell junction assembly | Any process that activates or increases the frequency, rate or extent of cell junction assembly. |
| positive regulation of cell-cell adhesion mediated by cadherin | Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin. |
| positive regulation of endocytosis | Any process that activates or increases the frequency, rate or extent of endocytosis. |
| protein kinase C signaling | A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| regulation of receptor internalization | Any process that modulates the frequency, rate or extent of receptor internalization. |
11 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| A6QLR4 | FLOT2 | Flotillin-2 | Bos taurus (Bovine) | PR |
| Q08DN8 | FLOT1 | Flotillin-1 | Bos taurus (Bovine) | PR |
| Q7YR41 | FLOT1 | Flotillin-1 | Pan troglodytes (Chimpanzee) | PR |
| O61491 | Flo1 | Flotillin-1 | Drosophila melanogaster (Fruit fly) | PR |
| O75955 | FLOT1 | Flotillin-1 | Homo sapiens (Human) | PR |
| Q14254 | FLOT2 | Flotillin-2 | Homo sapiens (Human) | PR |
| O08917 | Flot1 | Flotillin-1 | Mus musculus (Mouse) | PR |
| Q60634 | Flot2 | Flotillin-2 | Mus musculus (Mouse) | PR |
| Q767L6 | FLOT1 | Flotillin-1 | Sus scrofa (Pig) | PR |
| Q9Z2S9 | Flot2 | Flotillin-2 | Rattus norvegicus (Rat) | PR |
| Q9Z1E1 | Flot1 | Flotillin-1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFFTCGPNEA | MVVSGFCRSP | PVMVAGGRVF | VLPCIQQIQR | ISLNTLTLNV | KSEKVYTRHG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VPISVTGIAQ | VKIQGQNKEM | LAAACQMFLG | KTEAEIAHIA | LETLEGHQRA | IMAHMTVEEI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YKDRQKFSEQ | VFKVASSDLV | NMGISVVSYT | LKDIHDDQDY | LHSLGKARTA | QVQKDARIGE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AEAKRDAGIR | EAKAKQEKVS | AQYLSEIEMA | KAQRDYELKK | AAYDIEVNTR | RAQADLAYQL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QVAKTKQQIE | EQRVQVQVVE | RAQQVAVQEQ | EIARREKELE | ARVRKPAEAE | RYKLERLAEA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EKSQLIMQAE | AEAESVRMRG | EAEAFAIGAR | ARAEAEQMAK | KAEAFQLYQE | AAQLDMLLEK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LPQVAEEISG | PLTSANKITL | VSSGSGTMGA | AKVTGEVLDI | LTRLPESVER | LTGVSISQVN |
| HKPLRTA |