Q08DN8

PR
Gene name
FLOT1
Protein name
Flotillin-1
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:532573
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

140-423 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q08DN8

Entry ID Method Resolution Chain Position Source
AF-Q08DN8-F1 Predicted AlphaFoldDB

140 variants for Q08DN8

Variant ID(s) Position Change Description Diseaes Association Provenance
rs451392184 4 T>P No EVA
rs473146593 4 T>S No EVA
rs433729825 5 C>W No EVA
rs455522269 6 G>A No EVA
rs474053355 7 P>T No EVA
rs208061441 8 N>Y No EVA
rs444285319 9 E>G No EVA
rs462714601 12 V>L No EVA
rs471965422 19 S>T No EVA
rs482461385 47 T>S No EVA
rs449672243 65 V>G No EVA
rs452805164 71 V>G No EVA
rs470547653 76 Q>H No EVA
rs440809472 78 K>Q No EVA
rs452889674 81 L>Q No EVA
rs474728819 85 C>Y No EVA
rs441790839 87 M>I No EVA
rs482051548 91 K>R No EVA
rs439505588 93 E>G No EVA
rs458066431 94 A>G No EVA
rs447658499 98 H>Q No EVA
rs459740552 101 L>P No EVA
rs448532386 105 E>* No EVA
rs437382901 108 Q>P No EVA
rs434333147 111 I>F No EVA
rs452872612 112 M>R No EVA
rs474641841 115 M>L No EVA
rs435266574 116 T>N No EVA
rs475571833 117 V>G No EVA
rs439400822 118 E>A No EVA
rs439400822 118 E>G No EVA
rs440273525 162 H>P No EVA
rs473911624 196 Q>E No EVA
rs444346768 196 Q>L No EVA
rs457165410 219 K>T No EVA
rs439664615 225 I>L No EVA
rs458190740 226 E>D No EVA
rs469123327 231 R>G No EVA
rs440652823 232 A>V No EVA
rs462398792 241 Q>H No EVA
rs474833861 242 V>L No EVA
rs441913619 243 A>S No EVA
rs463668603 243 A>V No EVA
rs450070889 244 K>N No EVA
rs211377318 245 T>R No EVA
rs477531495 246 K>N No EVA
rs475005950 247 Q>P No EVA
rs475005950 247 Q>R No EVA
rs466182810 248 Q>K No EVA
rs1118281834 249 I>* No EVA
rs436574766 249 I>M No EVA
rs1118282672 250 E>* No EVA
rs1118275675 251 E>D No EVA
rs1118267192 251 E>Q No EVA
rs448659080 254 V>G No EVA
rs470512357 255 Q>R No EVA
rs436728776 256 V>E No EVA
rs436728776 256 V>G No EVA
rs452076434 257 Q>R No EVA
rs470612888 258 V>G No EVA
rs434450251 259 V>G No EVA
rs474768209 260 E>G No EVA
rs453048209 260 E>Q No EVA
rs379844194 261 R>G No EVA
rs463605107 261 R>Q No EVA
rs475749813 263 Q>E No EVA
rs475749813 263 Q>K No EVA
rs439531323 264 Q>E No EVA
rs458936071 264 Q>R No EVA
rs447667891 265 V>G No EVA
rs477483878 265 V>L No EVA
rs459695790 266 A>E No EVA
rs459695790 266 A>G No EVA
rs448595378 267 V>A No EVA
rs448595378 267 V>G No EVA
rs470420163 268 Q>E No EVA
rs437483379 268 Q>R No EVA
rs446340600 269 E>K No EVA
rs464139207 270 Q>K No EVA
rs434382689 270 Q>R No EVA
rs452986591 271 E>D No EVA
rs468273525 272 I>F No EVA
rs468273525 272 I>L No EVA
rs435325983 272 I>T No EVA
rs457118458 273 A>P No EVA
rs475644998 275 R>G No EVA
rs439464163 276 E>K No EVA
rs386111254 277 K>E No EVA
rs470768777 277 K>R No EVA
rs208542990 278 E>D No EVA
rs459632553 279 L>R No EVA
rs481316291 280 E>G No EVA
rs442115412 281 A>P No EVA
rs463948255 282 R>G No EVA
rs464836445 283 V>G No EVA
rs446292274 283 V>L No EVA
rs446455477 286 P>R No EVA
rs799844423 288 E>D No EVA
rs468212528 290 E>D No EVA
rs477711225 291 R>H No EVA
rs457007034 293 K>R No EVA
rs432990640 294 L>R No EVA
rs451539693 298 A>G No EVA
rs459324954 298 A>S No EVA
rs440307634 300 A>E No EVA
rs440307634 300 A>G No EVA
rs453177446 301 E>A No EVA
rs444962048 303 S>A No EVA
rs444962048 303 S>P No EVA
rs433775323 305 L>V No EVA
rs449061324 308 Q>H No EVA
rs457264509 311 A>E No EVA
rs437939525 311 A>P No EVA
rs442514106 318 M>L No EVA
rs461083630 318 M>R No EVA
rs482892794 320 G>A No EVA
rs482892794 320 G>E No EVA
rs449870808 322 A>T No EVA
rs478153965 324 A>S No EVA
rs445250468 325 F>L No EVA
rs467005556 326 A>P No EVA
rs434051333 327 I>M No EVA
rs455855054 329 A>P No EVA
rs438201343 332 R>S No EVA
rs467914696 332 R>W No EVA
rs472130608 337 Q>L No EVA
rs439103406 346 Q>E No EVA
rs453566516 356 M>L No EVA
rs453566516 356 M>V No EVA
rs472032221 357 L>P No EVA
rs442452677 360 K>Q No EVA
rs461068077 361 L>P No EVA
rs443419966 363 Q>P No EVA
rs465372535 373 T>P No EVA
rs521416826 376 N>S No EVA
rs432568082 397 V>L No EVA
rs443810583 399 D>N No EVA
rs447854251 418 Q>* No EVA
rs479360797 419 V>G No EVA
rs446457317 422 K>T No EVA

No associated diseases with Q08DN8

2 regional properties for Q08DN8

Type Name Position InterPro Accession
domain Band 7 domain 5 - 266 IPR001107
domain Flotillin, C-terminal domain 310 - 389 IPR031905

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Endosome
  • Membrane, caveola ; Peripheral membrane protein
  • Melanosome
  • Membrane raft
  • Identified by mass spectrometry in melanosome fractions from stage I to stage IV
  • Membrane-associated protein of caveola
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

18 GO annotations of cellular component

Name Definition
adherens junction A cell-cell junction composed of the epithelial cadherin-catenin complex. The epithelial cadherins, or E-cadherins, of each interacting cell extend through the plasma membrane into the extracellular space and bind to each other. The E-cadherins bind to catenins on the cytoplasmic side of the membrane, where the E-cadherin-catenin complex binds to cytoskeletal components and regulatory and signaling molecules.
basolateral plasma membrane The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
cell-cell contact zone Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle.
centriolar satellite A small (70-100 nm) cytoplasmic granule that contains a number of centrosomal proteins; centriolar satellites traffic toward microtubule minus ends and are enriched near the centrosome.
COP9 signalosome A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
cortical actin cytoskeleton The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
dopaminergic synapse A synapse that uses dopamine as a neurotransmitter.
early endosome A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
endosome A vacuole to which materials ingested by endocytosis are delivered.
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
flotillin complex A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.
lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
melanosome A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells.
membrane raft Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
sarcolemma The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
uropod A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.

1 GO annotations of molecular function

Name Definition
protease binding Binding to a protease or a peptidase.

24 GO annotations of biological process

Name Definition
axonogenesis De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells.
cellular response to exogenous dsRNA Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus.
dsRNA transport The directed movement of dsRNA, double-stranded ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
extracellular matrix disassembly A process that results in the breakdown of the extracellular matrix.
plasma membrane raft assembly The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft.
positive regulation of cell junction assembly Any process that activates or increases the frequency, rate or extent of cell junction assembly.
positive regulation of cell-cell adhesion mediated by cadherin Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin.
positive regulation of endocytosis Any process that activates or increases the frequency, rate or extent of endocytosis.
positive regulation of heterotypic cell-cell adhesion Any process that activates or increases the frequency, rate, or extent of heterotypic cell-cell adhesion.
positive regulation of interferon-beta production Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
positive regulation of myoblast fusion Any process that activates or increases the frequency, rate or extent of myoblast fusion.
positive regulation of NF-kappaB transcription factor activity Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
positive regulation of protein binding Any process that activates or increases the frequency, rate or extent of protein binding.
positive regulation of protein phosphorylation Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
positive regulation of skeletal muscle tissue development Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
positive regulation of synaptic transmission, dopaminergic Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.
positive regulation of toll-like receptor 3 signaling pathway Any process that activates or increases the frequency, rate, or extent of toll-like receptor 3 signaling pathway.
protein kinase C signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
regulation of neurotransmitter uptake Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell.
regulation of receptor internalization Any process that modulates the frequency, rate or extent of receptor internalization.
regulation of Rho protein signal transduction Any process that modulates the frequency, rate or extent of Rho protein signal transduction.
response to endoplasmic reticulum stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stress acting at the endoplasmic reticulum. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
A6QLR4 FLOT2 Flotillin-2 Bos taurus (Bovine) PR
Q7YR41 FLOT1 Flotillin-1 Pan troglodytes (Chimpanzee) PR
O61491 Flo1 Flotillin-1 Drosophila melanogaster (Fruit fly) PR
Q14254 FLOT2 Flotillin-2 Homo sapiens (Human) PR
O75955 FLOT1 Flotillin-1 Homo sapiens (Human) PR
Q60634 Flot2 Flotillin-2 Mus musculus (Mouse) PR
O08917 Flot1 Flotillin-1 Mus musculus (Mouse) PR
Q767L6 FLOT1 Flotillin-1 Sus scrofa (Pig) PR
Q9Z2S9 Flot2 Flotillin-2 Rattus norvegicus (Rat) PR
Q9Z1E1 Flot1 Flotillin-1 Rattus norvegicus (Rat) PR
Q5TM70 FLOT1 Flotillin-1 Macaca mulatta (Rhesus macaque) PR
10 20 30 40 50 60
MFFTCGPNEA MVVSGFCRSP PVMVAGGRVF VLPCIQQIQR ISLNTLTLNV KSEKVYTRHG
70 80 90 100 110 120
VPISVTGIAQ VKIQGQNKEM LAAACQMFLG KTEAEIAHIA LETLEGHQRA IMAHMTVEEI
130 140 150 160 170 180
YKDRQKFSEQ VFKVASSDLV NMGISVVSYT LKDIHDDQDY LHSLGKARTA QVQKDARIGE
190 200 210 220 230 240
AEAKRDAGIR EAKAKQEKVS AQYLSEIEMA KAQRDYELKK AAYDIEVNTR RAQADLAYQL
250 260 270 280 290 300
QVAKTKQQIE EQRVQVQVVE RAQQVAVQEQ EIARREKELE ARVRKPAEAE RYKLERLAEA
310 320 330 340 350 360
EKSQLIMQAE AEAEAVRMRG EAEAFAIGAR ARAEAEQMAK KAEAFQLYQE AAQLDMLLEK
370 380 390 400 410 420
LPQVAEEISG PLTSANKITL VSSGSGAMGA AKVTGEVLDI LSRLPESVER LTGVSISQVN
HKPLRTA