A6QLR4

PR
Gene name
FLOT2
Protein name
Flotillin-2
Names
Species
Bos taurus (Bovine)
KEGG Pathway
bta:615679
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

152-345 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for A6QLR4

Entry ID Method Resolution Chain Position Source
AF-A6QLR4-F1 Predicted AlphaFoldDB

112 variants for A6QLR4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs467926289 32 W>G No EVA
rs438641376 46 S>P No EVA
rs478146854 53 Q>P No EVA
rs440949929 65 V>E No EVA
rs440949929 65 V>G No EVA
rs455243032 72 V>G No EVA
rs464332048 75 V>G No EVA
rs445675313 76 K>R No EVA
rs478700506 79 T>S No EVA
rs460273440 89 E>G No EVA
rs441622073 90 Q>E No EVA
rs481039001 94 K>Q No EVA
rs462424950 95 S>R No EVA
rs443912527 113 S>P No EVA
rs467214831 118 L>V No EVA
rs455100719 119 T>R No EVA
rs469714614 121 E>G No EVA
rs469714614 121 E>V No EVA
rs451068737 125 Q>E No EVA
rs477632821 126 D>G No EVA
rs465444507 129 Q>K No EVA
rs482160403 138 A>G No EVA
rs449236354 138 A>S No EVA
rs463653129 142 V>G No EVA
rs459246656 152 F>L No EVA
rs457734473 162 D>N No EVA
rs439265699 175 V>G No EVA
rs472072169 177 R>G No EVA
rs441373428 180 D>Y No EVA
rs474420210 183 V>L No EVA
rs437281701 184 A>S No EVA
rs437819001 197 C>* No EVA
rs449785371 197 C>F No EVA
rs464227887 198 K>E No EVA
rs445777862 200 E>* No EVA
rs478561401 200 E>D No EVA
rs460134927 204 V>G No EVA
rs480965444 210 T>P No EVA
rs462486228 212 I>T No EVA
rs449856164 213 A>G No EVA
rs443774798 214 D>A No EVA
rs476634232 215 S>P No EVA
rs458046632 216 K>Q No EVA
rs439673833 219 F>S No EVA
rs472356937 222 Q>H No EVA
rs454041440 224 S>T No EVA
rs435619235 224 S>W No EVA
rs474886582 226 F>L No EVA
rs446189796 238 Q>H No EVA
rs479034168 243 L>M No EVA
rs460564902 246 A>V No EVA
rs442116007 247 R>H No EVA
rs481431284 250 Q>K No EVA
rs462951751 254 Q>H No EVA
rs444484372 255 E>D No EVA
rs470865538 257 I>S No EVA
rs452454380 259 I>S No EVA
rs440206494 261 V>G No EVA
rs454505118 264 R>G No EVA
rs469101229 266 K>T No EVA
rs456764961 268 I>L No EVA
rs431988742 268 I>M No EVA
rs446318308 270 V>G No EVA
rs467192793 271 E>A No EVA
rs481553099 273 Q>* No EVA
rs463085371 273 Q>R No EVA
rs444421436 274 E>D No EVA
rs477422326 275 I>T No EVA
rs458798745 276 L>P No EVA
rs458798745 276 L>R No EVA
rs440345426 277 R>H No EVA
rs440345426 277 R>P No EVA
rs454710092 278 T>P No EVA
rs442634118 280 K>R No EVA
rs475529913 281 E>D No EVA
rs456903644 282 L>P No EVA
rs431920777 283 I>S No EVA
rs431920777 283 I>T No EVA
rs471217668 284 A>P No EVA
rs452642637 285 T>A No EVA
rs434271093 285 T>M No EVA
rs452642637 285 T>P No EVA
rs467278987 286 V>A No EVA
rs467278987 286 V>G No EVA
rs448649477 287 R>G No EVA
rs436607751 287 R>P No EVA
rs451037043 288 C>R No EVA
rs477360959 288 C>S No EVA
rs458937820 289 P>H No EVA
rs479748272 290 A>D No EVA
rs442591669 291 E>G No EVA
rs461239936 291 E>Q No EVA
rs475622362 294 A>P No EVA
rs463243594 295 H>L No EVA
rs463243594 295 H>P No EVA
rs438462647 297 I>L No EVA
rs471356707 297 I>R No EVA
rs452778490 299 Q>P No EVA
rs439126633 360 V>G No EVA
rs462180485 367 I>L No EVA
rs443837747 373 A>D No EVA
rs482912048 394 E>K No EVA
rs439562234 395 V>A No EVA
rs458107634 395 V>L No EVA
rs472652773 396 N>T No EVA
rs441912155 397 R>L No EVA
rs452195036 411 G>R No EVA
rs466587673 416 K>N No EVA
rs444210688 418 P>S No EVA
rs470791930 425 G>C No EVA
rs433663725 427 Q>H No EVA
rs466669208 428 V>G No EVA

No associated diseases with A6QLR4

2 regional properties for A6QLR4

Type Name Position InterPro Accession
domain Band 7 domain 6 - 269 IPR001107
domain Flotillin, C-terminal domain 313 - 387 IPR031905

Functions

Description
EC Number
Subcellular Localization
  • Cell membrane ; Peripheral membrane protein
  • Membrane, caveola ; Peripheral membrane protein
  • Endosome
  • Membrane ; Lipid-anchor
  • Membrane-associated protein of caveolae
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
endosome A vacuole to which materials ingested by endocytosis are delivered.
flotillin complex A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
cell adhesion The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
protein localization to plasma membrane A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
regulation of myoblast differentiation Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08DN8 FLOT1 Flotillin-1 Bos taurus (Bovine) PR
Q7YR41 FLOT1 Flotillin-1 Pan troglodytes (Chimpanzee) PR
O61491 Flo1 Flotillin-1 Drosophila melanogaster (Fruit fly) PR
O75955 FLOT1 Flotillin-1 Homo sapiens (Human) PR
Q14254 FLOT2 Flotillin-2 Homo sapiens (Human) PR
O08917 Flot1 Flotillin-1 Mus musculus (Mouse) PR
Q60634 Flot2 Flotillin-2 Mus musculus (Mouse) PR
Q767L6 FLOT1 Flotillin-1 Sus scrofa (Pig) PR
Q9Z1E1 Flot1 Flotillin-1 Rattus norvegicus (Rat) PR
Q9Z2S9 Flot2 Flotillin-2 Rattus norvegicus (Rat) PR
Q5TM70 FLOT1 Flotillin-1 Macaca mulatta (Rhesus macaque) PR
10 20 30 40 50 60
MGNCHTVGPN EALVVSGGCC GSDYKQYVFG GWAWAWWCIS DTQRISLEIM TLQPRCEDVE
70 80 90 100 110 120
TAEGVALTVT GVAQVKIMTE KELLAVACEQ FLGKSVQDIK NVVLQTLEGH LRSILGTLTV
130 140 150 160 170 180
EQIYQDRDQF AKLVREVAAP DVGRMGIEIL SFTIKDVYDK VDYLSSLGKT QTAVVQRDAD
190 200 210 220 230 240
IGVAEAERDA GIREAECKKE MLDVKFMADT KIADSKRAFE LQKSAFSEEV NIKTAEAQLA
250 260 270 280 290 300
YELQGAREQQ KIRQEEIEIE VVQRKKQIAV EAQEILRTDK ELIATVRCPA EAEAHRIQQI
310 320 330 340 350 360
AEGEKVKQVL LAQAEAEKIR KIGEAEAAVI EARGKAEAER MKLKAEAYQK YGDAAKMALV
370 380 390 400 410 420
LDALPRIAAK IAAPLTKVDE IVVLSGDNSK VTSEVNRLLA ELPASVHALT GVDLSKIPLI
KKATGAQV