Q5E9E2
Gene name |
MYL9 (MYRL2) |
Protein name |
Myosin regulatory light polypeptide 9 |
Names |
Myosin regulatory light chain 2, smooth muscle isoform, Myosin regulatory light chain 9 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:531505 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5E9E2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5E9E2-F1 | Predicted | AlphaFoldDB |
36 variants for Q5E9E2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs474297177 | 2 | S>A | No | EVA | |
| rs444569980 | 2 | S>W | No | EVA | |
| rs463023782 | 3 | S>N | No | EVA | |
| rs477975701 | 7 | K>T | No | EVA | |
| rs460661328 | 8 | T>N | No | EVA | |
| rs445224750 | 8 | T>S | No | EVA | |
| rs479148752 | 10 | T>S | No | EVA | |
| rs468041110 | 11 | T>S | No | EVA | |
| rs449725206 | 12 | K>* | No | EVA | |
| rs465077043 | 15 | P>S | No | EVA | |
| rs431921824 | 17 | R>S | No | EVA | |
| rs453751621 | 19 | T>P | No | EVA | |
| rs466046744 | 21 | N>H | No | EVA | |
| rs436314371 | 21 | N>K | No | EVA | |
| rs466046744 | 21 | N>Y | No | EVA | |
| rs454637880 | 22 | V>M | No | EVA | |
| rs476408482 | 23 | F>L | No | EVA | |
| rs443416836 | 34 | F>V | No | EVA | |
| rs456590826 | 56 | D>G | No | EVA | |
| rs460419843 | 62 | G>R | No | EVA | |
| rs454043663 | 63 | K>* | No | EVA | |
| rs472701289 | 75 | N>H | No | EVA | |
| rs436368985 | 75 | N>K | No | EVA | |
| rs454877665 | 78 | P>A | No | EVA | |
| rs443939137 | 80 | P>T | No | EVA | |
| rs471145192 | 81 | I>L | No | EVA | |
| rs441464715 | 82 | N>D | No | EVA | |
| rs459422875 | 89 | M>R | No | EVA | |
| rs481213348 | 92 | E>Q | No | EVA | |
| rs445866313 | 113 | E>A | No | EVA | |
| rs1114487665 | 133 | R>Q | No | EVA | |
| rs1117166866 | 138 | E>K | No | EVA | |
| rs1118148651 | 143 | Y>* | No | EVA | |
| rs471557872 | 146 | A>G | No | EVA | |
| rs459785404 | 165 | H>L | No | EVA | |
| rs717320657 | 167 | A>V | No | EVA |
No associated diseases with Q5E9E2
4 regional properties for Q5E9E2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 29 - 77 | IPR002048-1 |
| domain | EF-hand domain | 98 - 133 | IPR002048-2 |
| domain | DJBP, EF-hand domain | 102 - 160 | IPR015070 |
| binding_site | EF-Hand 1, calcium-binding site | 42 - 54 | IPR018247 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| actomyosin | Any complex of actin, myosin, and accessory proteins. |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| myosin II complex | A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. |
| myosin II filament | A bipolar filament composed of myosin II molecules. |
| stress fiber | A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| glutamate receptor binding | Binding to a glutamate receptor. |
| myosin heavy chain binding | Binding to a heavy chain of a myosin complex. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| actomyosin structure organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments. |
| protein localization to plasma membrane | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. |
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9BUA6 | MYL10 | Myosin regulatory light chain 10 | Homo sapiens (Human) | PR |
| O14950 | MYL12B | Myosin regulatory light chain 12B | Homo sapiens (Human) | PR |
| P19105 | MYL12A | Myosin regulatory light chain 12A | Homo sapiens (Human) | PR |
| Q62082 | Myl10 | Myosin regulatory light chain 10 | Mus musculus (Mouse) | PR |
| P51667 | Myl2 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform | Mus musculus (Mouse) | PR |
| P97457 | Myl11 | Myosin regulatory light chain 11 | Mus musculus (Mouse) | PR |
| Q3THE2 | Myl12b | Myosin regulatory light chain 12B | Mus musculus (Mouse) | PR |
| P18666 | Myl12b | Myosin regulatory light chain 12B | Rattus norvegicus (Rat) | PR |
| P13832 | Rlc-a | Myosin regulatory light chain RLC-A | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSKRAKTKT | TKKRPQRATS | NVFAMFDQSQ | IQEFKEAFNM | IDQNRDGFID | KEDLHDMLAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGKNPTDEYL | DAMMNEAPGP | INFTMFLTMF | GEKLNGTDPE | DVIRNAFACF | DEEATGTIQE |
| 130 | 140 | 150 | 160 | 170 | |
| DYLRELLTTM | GDRFTDEEVD | ELYREAPIDK | KGNFNYIEFT | RILKHGAKDK | DD |