P13832
Gene name |
Rlc-a |
Protein name |
Myosin regulatory light chain RLC-A |
Names |
Myosin RLC-A, Myosin regulatory light chain 2-A, smooth muscle isoform |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:501203 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P13832
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P13832-F1 | Predicted | AlphaFoldDB |
2 variants for P13832
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs8153932 | 148 | I>M | No | EVA | |
| rs8157230 | 153 | N>Y | No | EVA |
No associated diseases with P13832
3 regional properties for P13832
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 29 - 77 | IPR002048-1 |
| domain | EF-hand domain | 98 - 164 | IPR002048-2 |
| binding_site | EF-Hand 1, calcium-binding site | 42 - 54 | IPR018247 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| myosin II complex | A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| myosin heavy chain binding | Binding to a heavy chain of a myosin complex. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9E2 | MYL9 | Myosin regulatory light polypeptide 9 | Bos taurus (Bovine) | PR |
| Q9BUA6 | MYL10 | Myosin regulatory light chain 10 | Homo sapiens (Human) | PR |
| O14950 | MYL12B | Myosin regulatory light chain 12B | Homo sapiens (Human) | PR |
| P19105 | MYL12A | Myosin regulatory light chain 12A | Homo sapiens (Human) | PR |
| Q62082 | Myl10 | Myosin regulatory light chain 10 | Mus musculus (Mouse) | PR |
| P51667 | Myl2 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform | Mus musculus (Mouse) | PR |
| P97457 | Myl11 | Myosin regulatory light chain 11 | Mus musculus (Mouse) | PR |
| Q3THE2 | Myl12b | Myosin regulatory light chain 12B | Mus musculus (Mouse) | PR |
| P18666 | Myl12b | Myosin regulatory light chain 12B | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSKRAKTKT | TKKRPQRATS | NVFAMFDQSQ | IQEFKEAFNM | IDQNRDGFID | KEDLHDMLAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MGKNPTDEYL | DAMMNEAPGP | INFTMFLTMF | GEKLNGTDPE | DVIRNAFACF | DEEAIGTIQE |
| 130 | 140 | 150 | 160 | 170 | |
| DYLRELLTTM | GDRFTDEEVD | ELYREAPIDK | KGNFNYIEFT | RILKHGAKDK | DD |