Q3THE2
Gene name |
Myl12b (Mrlc2, Mylc2b) |
Protein name |
Myosin regulatory light chain 12B |
Names |
Myosin regulatory light chain 2-B, smooth muscle isoform, Myosin regulatory light chain 20 kDa, MLC20, Myosin regulatory light chain MRLC2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:67938 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q3THE2
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q3THE2-F1 | Predicted | AlphaFoldDB |
10 variants for Q3THE2
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389457323 | 23 | F>Y | No | EVA | |
| rs3389470386 | 70 | L>Q | No | EVA | |
| rs3389425767 | 78 | P>R | No | EVA | |
| rs3389436132 | 83 | F>L | No | EVA | |
| rs3389436129 | 102 | V>I | No | EVA | |
| rs3389481408 | 103 | I>V | No | EVA | |
| rs3389494243 | 109 | C>Y | No | EVA | |
| rs3389390280 | 143 | Y>C | No | EVA | |
| rs3389494295 | 147 | P>T | No | EVA | |
| rs3389436156 | 170 | K>N | No | EVA |
No associated diseases with Q3THE2
4 regional properties for Q3THE2
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | EF-hand domain | 29 - 77 | IPR002048-1 |
| domain | EF-hand domain | 98 - 133 | IPR002048-2 |
| domain | DJBP, EF-hand domain | 102 - 160 | IPR015070 |
| binding_site | EF-Hand 1, calcium-binding site | 42 - 54 | IPR018247 |
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical part of cell | The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. |
| brush border | The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell. |
| cell cortex | The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| myofibril | The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism. |
| myosin II complex | A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
| stress fiber | A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber. |
| Z disc | Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion binding | Binding to a calcium ion (Ca2+). |
| myosin heavy chain binding | Binding to a heavy chain of a myosin complex. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| regulation of cell shape | Any process that modulates the surface configuration of a cell. |
9 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9E2 | MYL9 | Myosin regulatory light polypeptide 9 | Bos taurus (Bovine) | PR |
| P19105 | MYL12A | Myosin regulatory light chain 12A | Homo sapiens (Human) | PR |
| Q9BUA6 | MYL10 | Myosin regulatory light chain 10 | Homo sapiens (Human) | PR |
| O14950 | MYL12B | Myosin regulatory light chain 12B | Homo sapiens (Human) | PR |
| P51667 | Myl2 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform | Mus musculus (Mouse) | PR |
| P97457 | Myl11 | Myosin regulatory light chain 11 | Mus musculus (Mouse) | PR |
| Q62082 | Myl10 | Myosin regulatory light chain 10 | Mus musculus (Mouse) | PR |
| P13832 | Rlc-a | Myosin regulatory light chain RLC-A | Rattus norvegicus (Rat) | PR |
| P18666 | Myl12b | Myosin regulatory light chain 12B | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSKKAKTKT | TKKRPQRATS | NVFAMFDQSQ | IQEFKEAFNM | IDQNRDGFID | KEDLHDMLAS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LGKNPTDAYL | DAMMNEAPGP | INFTMFLTMF | GEKLNGTDPE | DVIRNAFACF | DEEATGTIQE |
| 130 | 140 | 150 | 160 | 170 | |
| DYLRELLTTM | GDRFTDEEVD | ELYREAPIDK | KGNFNYIEFT | RILKHGAKDK | DD |