Q58DW5
Gene name |
RPL5 |
Protein name |
60S ribosomal protein L5 |
Names |
|
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:515238 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q58DW5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q58DW5-F1 | Predicted | AlphaFoldDB |
40 variants for Q58DW5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs454211737 | 111 | N>Y | No | EVA | |
| rs471941150 | 112 | R>M | No | EVA | |
| rs432490971 | 112 | R>W | No | EVA | |
| rs456684113 | 113 | F>L | No | EVA | |
| rs456684113 | 113 | F>V | No | EVA | |
| rs468068269 | 115 | M>L | No | EVA | |
| rs449592055 | 116 | D>G | No | EVA | |
| rs433538217 | 117 | K>Q | No | EVA | |
| rs466446392 | 118 | I>S | No | EVA | |
| rs444895521 | 125 | V>G | No | EVA | |
| rs462712883 | 128 | D>A | No | EVA | |
| rs477710008 | 128 | D>H | No | EVA | |
| rs450617873 | 131 | N>K | No | EVA | |
| rs480523268 | 138 | Q>P | No | EVA | |
| rs461999554 | 139 | P>T | No | EVA | |
| rs472581798 | 143 | T>N | No | EVA | |
| rs440328526 | 143 | T>P | No | EVA | |
| rs460535311 | 144 | C>S | No | EVA | |
| rs438879581 | 145 | Y>* | No | EVA | |
| rs456690660 | 151 | A>T | No | EVA | |
| rs474454950 | 154 | T>A | No | EVA | |
| rs434297044 | 166 | A>D | No | EVA | |
| rs466358517 | 167 | V>G | No | EVA | |
| rs432814294 | 175 | H>Q | No | EVA | |
| rs469075116 | 176 | S>G | No | EVA | |
| rs435274029 | 188 | K>R | No | EVA | |
| rs468303329 | 193 | E>* | No | EVA | |
| rs446677245 | 210 | Y>C | No | EVA | |
| rs464434901 | 213 | E>D | No | EVA | |
| rs445996954 | 227 | I>L | No | EVA | |
| rs483223669 | 231 | V>E | No | EVA | |
| rs482461100 | 266 | W>L | No | EVA | |
| rs470420214 | 269 | P>S | No | EVA | |
| rs448717400 | 277 | K>R | No | EVA | |
| rs481725428 | 278 | D>G | No | EVA | |
| rs459306668 | 291 | Q>* | No | EVA | |
| rs440865757 | 292 | E>G | No | EVA | |
| rs477028551 | 294 | A>V | No | EVA | |
| rs458635605 | 296 | E>Q | No | EVA | |
| rs443341240 | 297 | S>N | No | EVA |
No associated diseases with Q58DW5
6 regional properties for Q58DW5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | HD/PDEase domain | 331 - 437 | IPR003607 |
| domain | K Homology domain | 207 - 274 | IPR004087 |
| domain | K Homology domain, type 1 | 213 - 266 | IPR004088 |
| domain | HD domain | 335 - 428 | IPR006674 |
| domain | HDIG domain | 331 - 408 | IPR006675 |
| domain | Ribonuclease Y, N-terminal | 5 - 204 | IPR022711 |
Functions
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosolic large ribosomal subunit | The large subunit of a ribosome located in the cytosol. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| 5S rRNA binding | Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. |
| structural constituent of ribosome | The action of a molecule that contributes to the structural integrity of the ribosome. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| ribosomal large subunit assembly | The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. |
| translation | The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P22451 | RPL5 | 60S ribosomal protein L5 | Gallus gallus (Chicken) | PR |
| P46777 | RPL5 | 60S ribosomal protein L5 | Homo sapiens (Human) | PR |
| P47962 | Rpl5 | 60S ribosomal protein L5 | Mus musculus (Mouse) | PR |
| P09895 | Rpl5 | 60S ribosomal protein L5 | Rattus norvegicus (Rat) | PR |
| P49405 | rpl-5 | 60S ribosomal protein L5 | Caenorhabditis elegans | PR |
| O76190 | RpL5 | 60S ribosomal protein L5 | Bombyx mori (Silk moth) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGFVKVVKNK | AYFKRYQVKF | RRRREGKTDY | YARKRLVIQD | KNKYNTPKYR | MIVRVTNRDI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ICQIAYARIE | GDMIVCAAYA | HELPKYGVKV | GLTNYAAAYC | TGLLLARRLL | NRFGMDKIYE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| GQVEVTGDEY | NVESIDGQPG | AFTCYLDAGL | ARTTTGNKVF | GALKGAVDGG | LSIPHSTKRF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PGYDSESKEF | SAEVHRKHIM | GQNVADYMRY | LIEEDEDAYK | KQFSQYIKNN | VTPDMMEEMY |
| 250 | 260 | 270 | 280 | 290 | |
| KKAHAAIREN | PVYEKKPKKE | VKKKRWNRPK | MSLAQKKDRV | AQKKASFLRA | QERAAES |