Q4KLH9
PR
Gene name |
Gpr4 |
Protein name |
G-protein coupled receptor 4 |
Names |
|
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:308408 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q4KLH9
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q4KLH9-F1 | Predicted | AlphaFoldDB |
No variants for Q4KLH9
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q4KLH9 | |||||
No associated diseases with Q4KLH9
1 regional properties for Q4KLH9
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| active_site | Glycoside hydrolase family 9, His active site | 390 - 416 | IPR018221 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP). |
| angiogenesis involved in wound healing | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| glomerular mesangial cell development | The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure. |
| negative regulation of angiogenesis | Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway | Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol. |
| positive regulation of inflammatory response | Any process that activates or increases the frequency, rate or extent of the inflammatory response. |
| positive regulation of Rho protein signal transduction | Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction. |
| regulation of cell adhesion | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. |
| regulation of vascular permeability | Any process that modulates the extent to which blood vessels can be pervaded by fluid. |
| response to acidic pH | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q1JQB3 | GPR4 | G-protein coupled receptor 4 | Bos taurus (Bovine) | PR |
| O46685 | GPR68 | Ovarian cancer G-protein coupled receptor 1 | Bos taurus (Bovine) | PR |
| P46093 | GPR4 | G-protein coupled receptor 4 | Homo sapiens (Human) | PR |
| Q8BUD0 | Gpr4 | G-protein coupled receptor 4 | Mus musculus (Mouse) | PR |
| Q8BFQ3 | Gpr68 | Ovarian cancer G-protein coupled receptor 1 | Mus musculus (Mouse) | PR |
| P50132 | GPR4 | G-protein coupled receptor 4 | Sus scrofa (Pig) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDNSTGTWEG | CHVDSRVDHL | FPPSLYIFVI | GVGLPTNCLA | LWAAYRQVRQ | RNELGVYLMN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LSIADLLYIC | TLPLWVDYFL | HHDNWIHGPG | SCKLFGFIFY | SNIYISIAFL | CCISVDRYLA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VAHPLRFARL | RRVKTAVAVS | SVVWATELGA | NSAPLFHDEL | FRDRYNHTFC | FEKFPMERWV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AWMNLYRVFV | GFLFPWALML | LCYRGILRAV | QSSVSTERQE | KVKIKRLALS | LIAIVLVCFA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PYHALLLSRS | AVYLGRPWDC | GFEERVFSAY | HSSLAFTSLN | CVADPILYCL | VNEGARSDVA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KALHNLLRFL | ASNKPQEMAN | ASLTLETPLT | SKRSTTGKTS | GAVWAVPPTA | QGDQVPLKVL |
| LPPAQ |