AiPD: Autoinhibited Protein Database

P46093

Gene name	GPR4
Protein name	G-protein coupled receptor 4
Names	G-protein coupled receptor 6C.l, GPR6C.l
Species	Homo sapiens (Human)
KEGG Pathway	hsa:2828
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

281-362 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

281-362 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P46093

Entry ID	Method	Resolution	Chain	Position	Source
AF-P46093-F1	Predicted				AlphaFoldDB

254 variants for P46093

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA9517706 rs755596295	3	N>I		No	ClinGen ExAC gnomAD
rs751982761 CA9517704	5	T>M		No	ClinGen ExAC gnomAD
CA9517702 rs757801617	6	W>*		No	ClinGen ExAC gnomAD
rs1157236809 CA406385492	9	C>Y		No	ClinGen gnomAD
CA406385474 rs199791684	10	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9517701 rs150678448	10	H>Y		No	ClinGen ESP ExAC TOPMed gnomAD
rs1316000841 CA406385464	11	V>L		No	ClinGen TOPMed gnomAD
TCGA novel rs1482241253 CA406385441	12	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen TOPMed NCI-TCGA
rs1179589214 CA406385434	13	S>W		No	ClinGen TOPMed
COSM1208716 CA406385422 rs1244375627	14	R>C	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs763872953 CA9517697	15	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1366698452 CA406385385	16	D>E		No	ClinGen TOPMed
rs1297732910 CA406385326	20	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
TCGA novel	20	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1227581520 CA406385284	23	L>R		No	ClinGen gnomAD
CA406385293 rs1369720675	23	L>V		No	ClinGen TOPMed
CA9517693 rs762899015	27	V>I		No	ClinGen ExAC gnomAD
CA9517692 rs773569959	28	I>V		No	ClinGen ExAC gnomAD
rs1318699174 CA406385205	29	G>A		No	ClinGen gnomAD
CA308983006 rs923000730	29	G>S		No	ClinGen Ensembl
CA9517691 rs770079267	30	V>M		No	ClinGen ExAC gnomAD
CA9517689 rs748363812	35	N>K		No	ClinGen ExAC gnomAD
rs1422515396 CA406384965	41	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA406384951 rs1600018292	42	A>P		No	ClinGen Ensembl
CA406384919 rs1600018282	43	Y>S		No	ClinGen Ensembl
CA9517685 rs780388154	44	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1469399830 CA406384891 COSM998250	44	R>H	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA308982981 rs780388154	44	R>S		No	ClinGen ExAC TOPMed gnomAD
rs757931306 CA9517684	47	Q>R		No	ClinGen ExAC TOPMed gnomAD
rs959207673 CA308982971	48	Q>K		No	ClinGen TOPMed
rs745312311 CA9517682 COSM3104374	49	R>C	ovary Variant assessed as Somatic; 0.0 impact. pancreas [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA308982964 rs964312226 COSM1579923	49	R>H	central_nervous_system [Cosmic]	No	ClinGen cosmic curated gnomAD
CA308982961 rs1034865115	50	N>Y		No	ClinGen TOPMed
CA9517680 rs753457588	54	V>F		No	ClinGen ExAC gnomAD
CA9517679 rs753457588	54	V>I		No	ClinGen ExAC gnomAD
TCGA novel	56	L>Q	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9517678 rs763926050	59	L>P		No	ClinGen ExAC gnomAD
rs755814980 CA9517677	60	S>N		No	ClinGen ExAC gnomAD
CA406384547 rs1568416369 COSM3797263	61	I>M	urinary_tract [Cosmic]	No	ClinGen cosmic curated Ensembl
CA9517675 rs767287643	63	D>N		No	ClinGen ExAC gnomAD
TCGA novel	65	L>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406384443 rs1369298586	68	C>G		No	ClinGen TOPMed gnomAD
CA9517670 rs776948508	72	L>P		No	ClinGen ExAC TOPMed gnomAD
CA308982925 rs776948508	72	L>R		No	ClinGen ExAC TOPMed gnomAD
CA406384267 rs1234243900	79	H>Y		No	ClinGen gnomAD
rs1465730638 CA406384237	80	H>Q		No	ClinGen TOPMed
rs183839594 CA9517668	80	H>R		No	ClinGen 1000Genomes ExAC gnomAD
rs776079288 CA9517667	81	D>G		No	ClinGen ExAC gnomAD
rs1272435176 CA406384194	84	I>V		No	ClinGen gnomAD
CA9517665 rs746369761	85	H>Y		No	ClinGen ExAC TOPMed gnomAD
rs756737747 CA406384166	86	G>C		No	ClinGen ExAC gnomAD
rs756737747 CA9517663	86	G>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1375869338 CA406384136	88	G>A		No	ClinGen gnomAD
rs1363606469 CA406384141	88	G>R		No	ClinGen TOPMed
rs551318972 CA9517662	89	S>T		No	ClinGen ExAC TOPMed gnomAD
rs1348972778 CA406384110	90	C>G		No	ClinGen gnomAD
rs1348972778 CA406384112	90	C>R		No	ClinGen gnomAD
rs1296724056 CA406384089	91	K>R		No	ClinGen TOPMed
CA9517660 rs755939582	92	L>F		No	ClinGen ExAC gnomAD
rs1466950875 CA406384034	95	F>S		No	ClinGen gnomAD
rs373741420 CA308982870	96	I>V		No	ClinGen ESP TOPMed
CA406383956 rs1600017999	99	T>P		No	ClinGen Ensembl
rs1174815621 CA406383942	100	N>H		No	ClinGen gnomAD
CA9517657 rs767326039	101	I>V		No	ClinGen ExAC
CA9517656 rs754934144	105	I>N		No	ClinGen ExAC gnomAD
CA406383821 rs1472156703 COSM1712505	106	A>T	Variant assessed as Somatic; 4.624e-05 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1306559855 CA406383809	107	F>L		No	ClinGen gnomAD
CA406383787 rs1249279251	108	L>R		No	ClinGen gnomAD
TCGA novel	115	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	118	A>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1318777456 CA406383615	120	A>V		No	ClinGen gnomAD
CA308982850 rs879046173	121	H>P		No	ClinGen gnomAD
rs764165492 CA9517651	124	R>H		No	ClinGen ExAC TOPMed gnomAD
rs764165492 CA406383560	124	R>L		No	ClinGen ExAC TOPMed gnomAD
rs144692714 CA406383544	125	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA406383530 rs1387169016	126	A>G		No	ClinGen TOPMed
CA406383528 rs1387169016	126	A>V		No	ClinGen TOPMed
CA9517649 rs772451809	127	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9517647 rs760083666	127	R>H		No	ClinGen ExAC
CA9517648 rs772451809	127	R>S		No	ClinGen ExAC TOPMed gnomAD
rs1301573697 CA406383522	128	L>Q		No	ClinGen gnomAD
TCGA novel	129	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA308982794 rs533175285	130	R>C		No	ClinGen TOPMed gnomAD
TCGA novel	130	R>H	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs770457704 CA406383508	131	V>I		No	ClinGen ExAC gnomAD
CA9517645 rs770457704	131	V>L		No	ClinGen ExAC gnomAD
rs1385402808 CA406383496	132	K>N		No	ClinGen TOPMed
rs748728533 CA9517644	133	T>N		No	ClinGen ExAC
rs77868669 CA308982793	133	T>P		No	ClinGen Ensembl
COSM566837 CA406383491 rs1409302412	134	A>S	lung Variant assessed as Somatic; 0.0 impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA9517641 rs747828205	134	A>V		No	ClinGen ExAC TOPMed gnomAD
rs540270313 CA9517639	135	V>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751583719 CA9517638	136	A>V		No	ClinGen ExAC gnomAD
CA9517636 rs757428926	137	V>A		No	ClinGen ExAC gnomAD
CA9517635 rs754030314	139	S>F		No	ClinGen ExAC
CA9517634 rs764232226	140	V>L		No	ClinGen ExAC gnomAD
TCGA novel	140	V>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs760848155 CA9517633	141	V>I		No	ClinGen ExAC gnomAD
rs1326378593 CA406383442	142	W>*		No	ClinGen TOPMed
CA406383436 COSM3692878 rs1303575895	143	A>D	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
rs1261191508 CA406383418	146	L>V		No	ClinGen TOPMed
CA406383409 rs1488055203	147	G>V		No	ClinGen TOPMed
rs1366750026 CA406383405	148	A>V		No	ClinGen gnomAD
CA406383389 rs1320717320	150	S>L		No	ClinGen gnomAD
rs781390832 CA308982720	151	A>T		No	ClinGen TOPMed
CA406383384 rs1386058464	151	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
TCGA novel	154	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs964429170 CA308982698	154	F>Y		No	ClinGen TOPMed gnomAD
rs1409854238 CA406383362	155	H>P		No	ClinGen TOPMed
rs771369207 CA9517627	156	D>E		No	ClinGen ExAC TOPMed gnomAD
rs763434229 CA406383344 CA9517626	157	E>D		No	ClinGen ExAC TOPMed gnomAD
rs1390698843 CA406383349	157	E>K		No	ClinGen gnomAD
CA9517624 rs769312976	160	R>*	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
TCGA novel	161	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406383314 rs1488368049	162	R>L		No	ClinGen gnomAD
CA406383307 rs1263982744	163	Y>C		No	ClinGen gnomAD
rs1600017615 CA406383272	168	C>R		No	ClinGen Ensembl
CA9517620 rs746746642	174	M>L		No	ClinGen ExAC gnomAD
rs1349769638 CA406383224	174	M>T		No	ClinGen TOPMed
CA9517619 rs779982502	175	E>A		No	ClinGen ExAC gnomAD
rs1305313766 CA406383198	177	W>C		No	ClinGen TOPMed
rs750344560 CA9517617	179	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1405169726 CA406383187	179	A>V		No	ClinGen TOPMed
CA9517616 rs777765101	181	M>L		No	ClinGen ExAC gnomAD
TCGA novel	186	V>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs966804387 CA308982608	188	V>L		No	ClinGen Ensembl
rs1370574841 CA406383120	189	G>D		No	ClinGen TOPMed
CA406383114 rs1419166216	190	F>C		No	ClinGen gnomAD
TCGA novel	191	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs752893984 CA9517614	191	L>V		No	ClinGen ExAC gnomAD
CA9517613 rs767657889	192	F>L		No	ClinGen ExAC gnomAD
rs1224930620 CA406383102	192	F>S		No	ClinGen TOPMed
rs78022169 CA308982604	193	P>L		No	ClinGen TOPMed
rs78022169 CA308982602	193	P>R		No	ClinGen TOPMed
rs1379388145 CA406383088	194	W>L		No	ClinGen gnomAD
rs778403402 CA9517611	195	A>T		No	ClinGen ExAC TOPMed gnomAD
CA308982592 rs754537867	195	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
CA406383078 rs1293668571	196	L>F		No	ClinGen TOPMed
CA406383073 rs1265516913	197	M>L		No	ClinGen TOPMed gnomAD
CA406383069 rs1568416086	197	M>R		No	ClinGen Ensembl
rs1184843317 CA406383050	200	S>L		No	ClinGen gnomAD
rs773744239 CA9517608	202	R>L		No	ClinGen ExAC TOPMed gnomAD
CA406383039 rs773744239	202	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs763487176 CA9517609	202	R>W		No	ClinGen ExAC TOPMed gnomAD
CA406383007 rs1233334346	208	V>L		No	ClinGen TOPMed gnomAD
rs1032163058 CA308982578	210	G>D		No	ClinGen TOPMed gnomAD
rs1000314680 CA308982567	216	R>L		No	ClinGen TOPMed gnomAD
CA9517603 rs746656909	225	L>P		No	ClinGen ExAC gnomAD
rs771971661 CA9517601	226	A>G		No	ClinGen ExAC gnomAD
CA9517602 rs771971661	226	A>V		No	ClinGen ExAC gnomAD
CA9517599 rs778870088	228	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
CA406382774 rs1376170039	228	S>R		No	ClinGen gnomAD
CA406382753 rs1352373705	230	I>L		No	ClinGen TOPMed
rs781235524 CA9517596	235	V>I		No	ClinGen ExAC gnomAD
CA9517593 rs377525265 CA9517594	242	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs377525265 CA406382581	242	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA9517591 rs758753596	243	L>R		No	ClinGen ExAC gnomAD
rs750901780 CA9517590	244	L>S		No	ClinGen ExAC gnomAD
rs1378434174 CA406382497	246	S>F		No	ClinGen TOPMed
rs1200574979 CA406382490	247	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA406382492 rs1200574979	247	R>G		No	ClinGen gnomAD
CA406382472 rs1260893166	248	S>G		No	ClinGen gnomAD
rs765721836 CA9517589	249	A>T		No	ClinGen ExAC gnomAD
rs763667046 CA9517587	250	I>S		No	ClinGen ExAC TOPMed gnomAD
rs763667046 CA9517586	250	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1334699507 CA406382426	251	Y>C		No	ClinGen gnomAD
rs1342241319 CA406382429	251	Y>H		No	ClinGen gnomAD
CA406382409 rs1227343789	252	L>V		No	ClinGen TOPMed
rs1260363525 CA406382395	253	G>S		No	ClinGen gnomAD
rs1239976098 CA406382367	254	R>C		No	ClinGen gnomAD
CA9517584 rs775235668	254	R>H		No	ClinGen ExAC TOPMed gnomAD
rs772022850 CA9517582	256	W>C		No	ClinGen ExAC gnomAD
CA406382331 CA406382329 rs1322820746	256	W>R		No	ClinGen gnomAD
CA308982458 rs905938359	257	D>E		No	ClinGen Ensembl
rs774169091 CA9517580	260	F>L		No	ClinGen ExAC gnomAD
rs1439750022 CA406382191	262	E>D		No	ClinGen TOPMed
rs753280506 CA9517579	263	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1568415993 CA406382152	265	F>C		No	ClinGen Ensembl
CA406382157 rs1441350570	265	F>L		No	ClinGen gnomAD
rs749174567 CA9517578	268	Y>C		No	ClinGen ExAC gnomAD
rs781286683 CA9517577	269	H>R		No	ClinGen ExAC TOPMed gnomAD
CA9517574 rs747251978	275	T>P		No	ClinGen ExAC gnomAD
rs750862282 CA9517571	281	A>E		No	ClinGen ExAC TOPMed gnomAD
rs750862282 CA9517572	281	A>V		No	ClinGen ExAC TOPMed gnomAD
CA406381802 rs1600017061	282	D>A		No	ClinGen Ensembl
CA9517568 rs754375362	285	L>I		No	ClinGen ExAC gnomAD
rs1435889609 CA406381722	286	Y>*		No	ClinGen TOPMed gnomAD
CA9517566 rs760223630	288	L>P		No	ClinGen ExAC gnomAD
CA406381633 rs1163195414	291	E>*		No	ClinGen gnomAD
rs1392557876 CA406381616	292	G>D		No	ClinGen gnomAD
rs1472136523 CA406381622	292	G>S		No	ClinGen gnomAD
rs759097182 CA9517563	293	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
VAR_049390 CA308982394 rs36012326	295	S>N		No	ClinGen UniProt Ensembl dbSNP
rs755698522 CA308982392	295	S>R		No	ClinGen TOPMed
rs371114196 CA308982391	296	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1247061369 CA406381563	296	D>H		No	ClinGen TOPMed gnomAD
CA406381565 rs1247061369	296	D>N		No	ClinGen TOPMed gnomAD
CA406381551 rs1213149128	296	D>V		No	ClinGen gnomAD
rs1268179353 CA406381540	297	V>M		No	ClinGen TOPMed
rs1341810841 CA406381485	300	A>T		No	ClinGen TOPMed
rs1290241344 CA406381418	303	N>S		No	ClinGen gnomAD
COSM998243 rs768730163 CA9517559	306	R>C	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA gnomAD
rs768730163 CA9517558	306	R>G		No	ClinGen ExAC gnomAD
rs201509344 CA9517557	306	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9517556 rs780097987	311	D>N		No	ClinGen ExAC gnomAD
CA9517555 rs372410283	313	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
CA308982367 rs900703201	314	Q>H		No	ClinGen TOPMed
TCGA novel	315	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406381190 rs1244200477	315	E>K		No	ClinGen TOPMed
CA308982365 rs933577404	316	M>I		No	ClinGen Ensembl
rs746047354 CA9517554	318	N>S		No	ClinGen ExAC TOPMed gnomAD
CA406381056 rs1169735251	321	L>I		No	ClinGen gnomAD
CA406381046 rs1429850311	321	L>P		No	ClinGen gnomAD
CA406381055 rs1169735251	321	L>V		No	ClinGen gnomAD
CA406381020 rs1388947877	323	L>V		No	ClinGen gnomAD
rs757517157 CA9517552	326	P>A		No	ClinGen ExAC gnomAD
rs1406806571 CA406380940	327	L>P		No	ClinGen TOPMed
CA406380934 rs1600016829	328	T>P		No	ClinGen Ensembl
rs755697057 CA9517549	329	S>F		No	ClinGen ExAC TOPMed gnomAD
CA406380906 rs755697057	329	S>Y		No	ClinGen ExAC TOPMed gnomAD
CA9517547 rs766931648	332	N>I		No	ClinGen ExAC TOPMed gnomAD
rs1431148486 CA406380838	333	S>G		No	ClinGen TOPMed
CA308982344 rs528955502	334	T>K		No	ClinGen gnomAD
CA308982347 rs917571690	334	T>S		No	ClinGen TOPMed
rs1341552176 CA406380813	335	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs943571939 CA308982342	336	K>E		No	ClinGen Ensembl
rs759269013 CA9517546	337	A>P		No	ClinGen ExAC gnomAD
CA9517545 rs751145496	338	M>L		No	ClinGen ExAC TOPMed gnomAD
CA406380774 rs751145496	338	M>V		No	ClinGen ExAC TOPMed gnomAD
CA406380753 rs1600016757	339	T>I		No	ClinGen Ensembl
rs1368639765 CA406380734	341	S>R		No	ClinGen gnomAD
CA406380729 rs1274459785	342	W>L		No	ClinGen gnomAD
TCGA novel	343	A>missing	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA406380722 rs1352660136	343	A>E		No	ClinGen TOPMed gnomAD
rs1352660136 CA406380721	343	A>G		No	ClinGen TOPMed gnomAD
CA9517544 rs766216041	343	A>S		No	ClinGen ExAC gnomAD
rs1352660136 CA406380720	343	A>V		No	ClinGen TOPMed gnomAD
rs200530342 CA9517542	344	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA9517541 rs769783412	344	A>V		No	ClinGen ExAC gnomAD
rs761739112 CA9517540	345	T>I		No	ClinGen ExAC gnomAD
rs1600016703 CA406380715	345	T>P		No	ClinGen Ensembl
rs551669816 CA9517538	346	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
rs551669816 CA406380707	346	P>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1203914271 CA406380708	346	P>S		No	ClinGen TOPMed
rs778965698 CA9517536	347	P>L		No	ClinGen ExAC gnomAD
CA308982325 rs945031275	351	D>N		No	ClinGen TOPMed
CA406380679 rs945031275	351	D>Y		No	ClinGen TOPMed
CA9517534 rs749605411	352	Q>E		No	ClinGen ExAC gnomAD
rs145450390 CA9517531	359	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA9517532 rs201440587	359	P>S		No	ClinGen ESP ExAC TOPMed gnomAD
CA406380618 rs1426045079	360	P>L		No	ClinGen Ensembl
CA406380615 rs1331662690	361	A>T		No	ClinGen gnomAD
rs754393335 CA9517529	361	A>V		No	ClinGen ExAC TOPMed gnomAD
rs1228150117 CA406380609	362	Q>E		No	ClinGen gnomAD

No associated diseases with P46093

1 regional properties for P46093

Type	Name	Position	InterPro Accession
domain	GPCR, rhodopsin-like, 7TM	34 - 286	IPR017452

Functions

		Description
EC Number
Subcellular Localization	Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

2 GO annotations of cellular component

Name	Definition
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name	Definition
G protein-coupled receptor activity	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.

12 GO annotations of biological process

Name	Definition
adenylate cyclase-activating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity and a subsequent increase in the intracellular concentration of cyclic AMP (cAMP).
angiogenesis involved in wound healing	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury.
G protein-coupled receptor signaling pathway	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.
glomerular mesangial cell development	The process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure.
negative regulation of angiogenesis	Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis.
phospholipase C-activating G protein-coupled receptor signaling pathway	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway	Any process that increases the concentration of calcium ions in the cytosol that occurs as part of a PLC-activating G protein-coupled receptor signaling pathway. G-protein-activated PLC hydrolyses phosphatidylinositol-bisphosphate (PIP2) to release diacylglycerol (DAG) and inositol trisphosphate (IP3). IP3 then binds to calcium release channels in the endoplasmic reticulum (ER) to trigger calcium ion release into the cytosol.
positive regulation of inflammatory response	Any process that activates or increases the frequency, rate or extent of the inflammatory response.
positive regulation of Rho protein signal transduction	Any process that activates or increases the frequency, rate or extent of Rho protein signal transduction.
regulation of cell adhesion	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix.
regulation of vascular permeability	Any process that modulates the extent to which blood vessels can be pervaded by fluid.
response to acidic pH	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.

6 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q1JQB3	GPR4	G-protein coupled receptor 4	Bos taurus (Bovine)	PR
O46685	GPR68	Ovarian cancer G-protein coupled receptor 1	Bos taurus (Bovine)	PR
Q8BUD0	Gpr4	G-protein coupled receptor 4	Mus musculus (Mouse)	PR
Q8BFQ3	Gpr68	Ovarian cancer G-protein coupled receptor 1	Mus musculus (Mouse)	PR
P50132	GPR4	G-protein coupled receptor 4	Sus scrofa (Pig)	PR
Q4KLH9	Gpr4	G-protein coupled receptor 4	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MGNHTWEGCH	VDSRVDHLFP	PSLYIFVIGV	GLPTNCLALW	AAYRQVQQRN	ELGVYLMNLS
70	80	90	100	110	120
IADLLYICTL	PLWVDYFLHH	DNWIHGPGSC	KLFGFIFYTN	IYISIAFLCC	ISVDRYLAVA
130	140	150	160	170	180
HPLRFARLRR	VKTAVAVSSV	VWATELGANS	APLFHDELFR	DRYNHTFCFE	KFPMEGWVAW
190	200	210	220	230	240
MNLYRVFVGF	LFPWALMLLS	YRGILRAVRG	SVSTERQEKA	KIKRLALSLI	AIVLVCFAPY
250	260	270	280	290	300
HVLLLSRSAI	YLGRPWDCGF	EERVFSAYHS	SLAFTSLNCV	ADPILYCLVN	EGARSDVAKA
310	320	330	340	350	360
LHNLLRFLAS	DKPQEMANAS	LTLETPLTSK	RNSTAKAMTG	SWAATPPSQG	DQVQLKMLPP

AQ