O46685
PR
Gene name |
GPR68 |
Protein name |
Ovarian cancer G-protein coupled receptor 1 |
Names |
G protein-coupled receptor RGR1, bRGR1, G-protein coupled receptor 68 |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:281799 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O46685
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O46685-F1 | Predicted | AlphaFoldDB |
141 variants for O46685
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs475371237 | 5 | T>P | No | EVA | |
| rs456931029 | 22 | T>P | No | EVA | |
| rs432218064 | 26 | V>G | No | EVA | |
| rs465216678 | 34 | V>L | No | EVA | |
| rs453230208 | 43 | L>H | No | EVA | |
| rs453230208 | 43 | L>R | No | EVA | |
| rs467435530 | 66 | A>P | No | EVA | |
| rs448456069 | 67 | D>A | No | EVA | |
| rs469162286 | 73 | S>F | No | EVA | |
| rs481340985 | 73 | S>P | No | EVA | |
| rs450806072 | 97 | C>S | No | EVA | |
| rs477478111 | 110 | G>A | No | EVA | |
| rs459176741 | 118 | D>G | No | EVA | |
| rs440723816 | 120 | Y>S | No | EVA | |
| rs479977931 | 125 | H>P | No | EVA | |
| rs443663346 | 130 | H>P | No | EVA | |
| rs461564362 | 131 | Q>L | No | EVA | |
| rs442498280 | 132 | F>L | No | EVA | |
| rs475512359 | 140 | G>R | No | EVA | |
| rs457067463 | 145 | I>N | No | EVA | |
| rs438382162 | 147 | V>I | No | EVA | |
| rs471432349 | 152 | T>S | No | EVA | |
| rs453113669 | 155 | Y>F | No | EVA | |
| rs434661440 | 158 | M>R | No | EVA | |
| rs473772568 | 159 | H>P | No | EVA | |
| rs455373879 | 160 | E>G | No | EVA | |
| rs436412687 | 161 | E>G | No | EVA | |
| rs469299359 | 163 | V>G | No | EVA | |
| rs471843776 | 164 | E>G | No | EVA | |
| rs451022072 | 165 | D>A | No | EVA | |
| rs465389837 | 167 | D>A | No | EVA | |
| rs447074613 | 169 | H>P | No | EVA | |
| rs480115386 | 172 | C>Y | No | EVA | |
| rs463399864 | 174 | E>D | No | EVA | |
| rs482464701 | 174 | E>G | No | EVA | |
| rs449493030 | 174 | E>K | No | EVA | |
| rs438518405 | 175 | H>L | No | EVA | |
| rs471334594 | 176 | Y>N | No | EVA | |
| rs473913603 | 178 | L>F | No | EVA | |
| rs455514521 | 178 | L>P | No | EVA | |
| rs455514521 | 178 | L>R | No | EVA | |
| rs436955012 | 182 | Q>P | No | EVA | |
| rs476471498 | 185 | I>L | No | EVA | |
| rs457336403 | 187 | Y>C | No | EVA | |
| rs432481682 | 188 | Y>S | No | EVA | |
| rs434816719 | 196 | F>C | No | EVA | |
| rs446871535 | 196 | F>I | No | EVA | |
| rs468069019 | 201 | L>M | No | EVA | |
| rs482401464 | 206 | R>G | No | EVA | |
| rs463977641 | 206 | R>Q | No | EVA | |
| rs459236254 | 208 | I>M | No | EVA | |
| rs477944498 | 208 | I>V | No | EVA | |
| rs440757592 | 211 | A>P | No | EVA | |
| rs473649800 | 212 | V>A | No | EVA | |
| rs443521104 | 219 | Q>E | No | EVA | |
| rs476381185 | 221 | S>R | No | EVA | |
| rs451485420 | 223 | K>Q | No | EVA | |
| rs438843960 | 224 | D>E | No | EVA | |
| rs471905211 | 232 | S>R | No | EVA | |
| rs453480571 | 233 | T>N | No | EVA | |
| rs434753370 | 234 | V>G | No | EVA | |
| rs455993612 | 235 | V>A | No | EVA | |
| rs467807201 | 235 | V>F | No | EVA | |
| rs455993612 | 235 | V>G | No | EVA | |
| rs445433745 | 239 | A>D | No | EVA | |
| rs465876320 | 240 | C>* | No | EVA | |
| rs478488954 | 240 | C>F | No | EVA | |
| rs465876320 | 240 | C>W | No | EVA | |
| rs480003100 | 243 | P>H | No | EVA | |
| rs461601943 | 246 | V>A | No | EVA | |
| rs443440060 | 247 | L>V | No | EVA | |
| rs482978085 | 248 | L>V | No | EVA | |
| rs458006632 | 254 | W>R | No | EVA | |
| rs439384413 | 255 | E>* | No | EVA | |
| rs472412539 | 258 | C>S | No | EVA | |
| rs441358267 | 266 | N>S | No | EVA | |
| rs470489255 | 268 | Y>* | No | EVA | |
| rs437440928 | 268 | Y>C | No | EVA | |
| rs437440928 | 268 | Y>F | No | EVA | |
| rs455730007 | 268 | Y>H | No | EVA | |
| rs437440928 | 268 | Y>S | No | EVA | |
| rs451956635 | 269 | H>L | No | EVA | |
| rs451956635 | 269 | H>P | No | EVA | |
| rs433346014 | 272 | L>P | No | EVA | |
| rs466235875 | 273 | L>P | No | EVA | |
| rs480124106 | 275 | T>A | No | EVA | |
| rs480124106 | 275 | T>P | No | EVA | |
| rs467968399 | 276 | S>T | No | EVA | |
| rs449655521 | 278 | N>D | No | EVA | |
| rs482733981 | 281 | A>T | No | EVA | |
| rs458023579 | 282 | D>A | No | EVA | |
| rs458023579 | 282 | D>G | No | EVA | |
| rs439525097 | 289 | V>L | No | EVA | |
| rs478822114 | 293 | T>P | No | EVA | |
| rs460359196 | 294 | H>P | No | EVA | |
| rs441293740 | 295 | R>G | No | EVA | |
| rs474302018 | 296 | D>A | No | EVA | |
| rs462280217 | 297 | L>M | No | EVA | |
| rs443609854 | 297 | L>R | No | EVA | |
| rs476652794 | 298 | A>P | No | EVA | |
| rs451964847 | 298 | A>V | No | EVA | |
| rs454188741 | 300 | L>R | No | EVA | |
| rs472559732 | 300 | L>V | No | EVA | |
| rs435792069 | 302 | G>E | No | EVA | |
| rs468103508 | 303 | A>S | No | EVA | |
| rs449733868 | 304 | C>G | No | EVA | |
| rs437581398 | 305 | L>R | No | EVA | |
| rs464139798 | 306 | A>S | No | EVA | |
| rs445896070 | 309 | T>A | No | EVA | |
| rs445896070 | 309 | T>P | No | EVA | |
| rs478907135 | 310 | C>* | No | EVA | |
| rs478907135 | 310 | C>W | No | EVA | |
| rs460291943 | 311 | A>S | No | EVA | |
| rs481257635 | 313 | T>P | No | EVA | |
| rs462220627 | 315 | R>P | No | EVA | |
| rs443729607 | 316 | A>P | No | EVA | |
| rs458088230 | 320 | Y>* | No | EVA | |
| rs476606416 | 320 | Y>C | No | EVA | |
| rs472699133 | 328 | S>A | No | EVA | |
| rs435730636 | 330 | K>E | No | EVA | |
| rs475044896 | 330 | K>R | No | EVA | |
| rs456182380 | 332 | E>D | No | EVA | |
| rs437709226 | 333 | D>G | No | EVA | |
| rs464118502 | 336 | V>D | No | EVA | |
| rs445597140 | 338 | T>K | No | EVA | |
| rs433598411 | 339 | R>S | No | EVA | |
| rs448417834 | 340 | L>P | No | EVA | |
| rs448417834 | 340 | L>R | No | EVA | |
| rs466862381 | 340 | L>V | No | EVA | |
| rs481198158 | 341 | H>P | No | EVA | |
| rs462738572 | 342 | P>S | No | EVA | |
| rs450138157 | 346 | T>P | No | EVA | |
| rs483197549 | 348 | H>D | No | EVA | |
| rs458287531 | 348 | H>P | No | EVA | |
| rs439559526 | 349 | P>T | No | EVA | |
| rs478842228 | 350 | P>L | No | EVA | |
| rs442295443 | 352 | M>I | No | EVA | |
| rs474981754 | 355 | S>A | No | EVA | |
| rs474981754 | 355 | S>P | No | EVA | |
| rs470660163 | 361 | S>P | No | EVA | |
| rs452223556 | 362 | S>Q | No | EVA |
No associated diseases with O46685
1 regional properties for O46685
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Golgin subfamily A member 7/ERF4 | 21 - 133 | IPR019383 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to pH | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. |
| insulin secretion | The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects. |
| monocyte differentiation | The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte. |
| negative regulation of monocyte differentiation | Any process that stops, prevents, or reduces the frequency, rate or extent of monocyte differentiation. |
| osteoclast development | The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue. |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus | Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose. |
| positive regulation of osteoclast development | Any process that activates or increases the frequency, rate or extent of osteoclast development. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q1JQB3 | GPR4 | G-protein coupled receptor 4 | Bos taurus (Bovine) | PR |
| P46093 | GPR4 | G-protein coupled receptor 4 | Homo sapiens (Human) | PR |
| Q8BFQ3 | Gpr68 | Ovarian cancer G-protein coupled receptor 1 | Mus musculus (Mouse) | PR |
| Q8BUD0 | Gpr4 | G-protein coupled receptor 4 | Mus musculus (Mouse) | PR |
| Q4KLH9 | Gpr4 | G-protein coupled receptor 4 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGNITADNTS | MNCDIDHTIH | QTLAPVVYVM | VLVVGFPANC | LSLYYGYLQI | KARNELGVYL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CNLTVADLFY | ICSLPFWLQY | VLQHDHWSHD | DLSCQVCGIL | LYENIYISVG | FLCCISIDRY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LAVAHPFRFH | QFRTLKAAMG | VSALIWVKEL | LTSIYFLMHE | EVVEDADRHR | VCFEHYPLEP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RQRGINYYRF | LVGFLFPICL | LLASYRGILR | AVRRSHGTQK | SRKDQIQRLV | LSTVVIFLAC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FLPYHVLLLV | RSLWESSCDF | AKGIFNAYHF | SLLLTSFNCV | ADPVLYCFVS | ETTHRDLARL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RGACLAFLTC | ARTGRAREAY | PLGAPEASGK | SEDPEVLTRL | HPAFQTPHPP | GMGGSPAGGL |
| S |