Q04660

PR
Gene name
ERB1
Protein name
Ribosome biogenesis protein ERB1
Names
Eukaryotic ribosome biogenesis protein 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YMR049C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-178 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

23 structures for Q04660

Entry ID Method Resolution Chain Position Source
4U7A X-ray 160 A A 1-807 PDB
6C0F EM 370 A s 1-807 PDB
6CB1 EM 460 A PDB
6ELZ EM 330 A m 1-807 PDB
6EM1 EM 360 A m 1-807 PDB
6EM3 EM 320 A B 1-807 PDB
6EM4 EM 410 A H 1-807 PDB
6EM5 EM 430 A m 1-807 PDB
7NAC EM 304 A m 1-807 PDB
7NAD EM 304 A m 392-807 PDB
7OHP EM 390 A m 1-807 PDB
7OHR EM 472 A m 1-807 PDB
7OHS EM 438 A m 1-807 PDB
7OHV EM 390 A m 1-807 PDB
7OHW EM 350 A m 1-807 PDB
7OHX EM 330 A m 1-807 PDB
7R6K EM 317 A m 1-807 PDB
7R6Q EM 298 A m 1-807 PDB
7R72 EM 307 A m 392-807 PDB
7R7A EM 304 A m 1-807 PDB
7R7C EM 371 A m 153-215 PDB
8E5T EM 400 A s 1-807 PDB
AF-Q04660-F1 Predicted AlphaFoldDB

10 variants for Q04660

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-370245 91 G>E No SGRP
s13-369811 236 S>G No SGRP
s13-369793 242 P>A No SGRP
s13-369609 303 I>T No SGRP
s13-369493 342 E>K No SGRP
s13-369418 367 I>V No SGRP
s13-369061 486 Y>D No SGRP
s13-368860 553 G>S No SGRP
s13-368821 566 N>D No SGRP
s13-368206 771 T>A No SGRP

No associated diseases with Q04660

7 regional properties for Q04660

Type Name Position InterPro Accession
repeat WD40 repeat 426 - 474 IPR001680-1
repeat WD40 repeat 628 - 666 IPR001680-2
repeat WD40 repeat 669 - 708 IPR001680-3
repeat WD40 repeat 712 - 751 IPR001680-4
repeat WD40 repeat 763 - 807 IPR001680-5
domain BOP1, N-terminal domain 165 - 426 IPR012953
conserved_site WD40 repeat, conserved site 452 - 466 IPR019775

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
  • Nucleus, nucleoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
PeBoW complex A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively.
preribosome, large subunit precursor A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit.

3 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
large ribosomal subunit rRNA binding Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA.
ribonucleoprotein complex binding Binding to a complex of RNA and protein.

4 GO annotations of biological process

Name Definition
maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript.
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.
ribosomal large subunit biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q7K0Y1 CG5033 Ribosome biogenesis protein BOP1 homolog Drosophila melanogaster (Fruit fly) PR
Q14137 BOP1 Ribosome biogenesis protein BOP1 Homo sapiens (Human) PR
P97452 Bop1 Ribosome biogenesis protein BOP1 Mus musculus (Mouse) PR
Q562C2 Bop1 Ribosome biogenesis protein BOP1 Rattus norvegicus (Rat) PR
Q9U2A9 Y48B6A.1 Ribosome biogenesis protein BOP1 homolog Caenorhabditis elegans PR
A0JMQ0 bop1 Ribosome biogenesis protein bop1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MMAKNNKTTE AKMSKKRAAS EESDVEEDED KLLSVDGLID AEASESDEDD DEYESAVEEK
70 80 90 100 110 120
ESSSDKEAQD DSDDDSDAEL NKLLAEEEGD GEEDYDSSEF SDDTTSLTDR LSGVKLQTIV
130 140 150 160 170 180
DPNIYSKYAD GSDRIIKPEI NPVYDSDDSD AETQNTIGNI PLSAYDEMPH IGYDINGKRI
190 200 210 220 230 240
MRPAKGSALD QLLDSIELPE GWTGLLDKNS GSSLNLTKEE LELISKIQRN EQTDDSINPY
250 260 270 280 290 300
EPLIDWFTRH EEVMPLTAVP EPKRRFVPSK NEAKRVMKIV RAIREGRIIP PKKLKEMKEK
310 320 330 340 350 360
EKIENYQYDL WGDSTETNDH VMHLRAPKLP PPTNEESYNP PEEYLLSPEE KEAWENTEYS
370 380 390 400 410 420
ERERNFIPQK YSALRKVPGY GESIRERFER SLDLYLAPRV RKNKLNIDPN SLIPELPSPK
430 440 450 460 470 480
DLRPFPIRCS TIYAGHKGKV RTLSIDPSGL WLATGSDDGT VRVWEILTGR EVYRTTLIDD
490 500 510 520 530 540
EENPDYHIEC IEWNPDANNG ILAVAVGENI HLIVPPIFGY DIENNGKTKI EDGFGYDTFG
550 560 570 580 590 600
TVKKSNLEVN ENGDGDEDGE NESAKNAVKK QVAQWNKPSQ KQLEKDICIT ISCKKTVKKL
610 620 630 640 650 660
SWHRKGDYFV TVQPDSGNTS VLIHQVSKHL TQSPFKKSKG IIMDAKFHPF KPQLFVCSQR
670 680 690 700 710 720
YVRIYDLSQQ ILVKKLLPGA RWLSKIDIHP RGDNLIASSF DKRVLWHDLD LASTPYKTLR
730 740 750 760 770 780
YHEKAVRSVN FHKKLPLFSS AADDGTIHVF HATVYDDMMK NPMIVPLKKL TGHKVINSLG
790 800
VLDAIWHPRE AWLFSAGADN TARLWTT