P97452
PR
Gene name |
Bop1 (Kiaa0124) |
Protein name |
Ribosome biogenesis protein BOP1 |
Names |
Block of proliferation 1 protein |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12181 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P97452
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P97452-F1 | Predicted | AlphaFoldDB |
39 variants for P97452
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389363870 | 6 | G>D | No | EVA | |
| rs3413090615 | 45 | S>R | No | EVA | |
| rs47528138 | 55 | D>E | No | EVA | |
| rs31966277 | 56 | L>S | No | EVA | |
| rs242548908 | 61 | S>G | No | EVA | |
| rs13464531 | 71 | S>A | No | EVA | |
| rs232223204 | 76 | D>G | No | EVA | |
| rs262791993 | 82 | E>K | No | EVA | |
| rs51379649 | 87 | L>P | No | EVA | |
| rs3389319736 | 89 | Q>H | No | EVA | |
| rs259095598 | 98 | E>K | No | EVA | |
| rs239573375 | 104 | A>T | No | EVA | |
| rs3389377793 | 154 | E>D | No | EVA | |
| rs3389349131 | 157 | Q>K | No | EVA | |
| rs3389331361 | 186 | Q>K | No | EVA | |
| rs3389338825 | 196 | G>C | No | EVA | |
| rs215570301 | 215 | G>S | No | EVA | |
| rs3389370350 | 230 | R>L | No | EVA | |
| rs226912218 | 314 | S>L | No | EVA | |
| rs3389349137 | 384 | L>F | No | EVA | |
| rs247582766 | 406 | S>G | No | EVA | |
| rs3389349171 | 482 | D>Y | No | EVA | |
| rs3389358810 | 485 | L>M | No | EVA | |
| rs3389368229 | 574 | H>Y | No | EVA | |
| rs3406306376 | 585 | Q>H | No | EVA | |
| rs3389363913 | 587 | S>G | No | EVA | |
| rs3406394945 | 587 | S>RW* | No | EVA | |
| rs3389319777 | 622 | I>V | No | EVA | |
| rs3389363938 | 634 | D>E | No | EVA | |
| rs3389370401 | 642 | Y>N | No | EVA | |
| rs3406264848 | 658 | H>Y | No | EVA | |
| rs3389331338 | 672 | S>N | No | EVA | |
| rs3389362394 | 677 | H>N | No | EVA | |
| rs3389362322 | 681 | Y>H | No | EVA | |
| rs3389349125 | 692 | P>H | No | EVA | |
| rs3389331387 | 706 | G>D | No | EVA | |
| rs3389370342 | 710 | V>M | No | EVA | |
| rs3389338801 | 715 | T>I | No | EVA | |
| rs3406252364 | 733 | S>= | No | EVA |
No associated diseases with P97452
8 regional properties for P97452
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 388 - 469 | IPR001680-1 |
| repeat | WD40 repeat | 508 - 551 | IPR001680-2 |
| repeat | WD40 repeat | 554 - 592 | IPR001680-3 |
| repeat | WD40 repeat | 595 - 634 | IPR001680-4 |
| repeat | WD40 repeat | 638 - 677 | IPR001680-5 |
| repeat | WD40 repeat | 689 - 732 | IPR001680-6 |
| domain | BOP1, N-terminal domain | 130 - 388 | IPR012953 |
| conserved_site | WD40 repeat, conserved site | 414 - 428 | IPR019775 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| chromosome | A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| PeBoW complex | A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively. |
| preribosome, large subunit precursor | A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribonucleoprotein complex binding | Binding to a complex of RNA and protein. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| cell population proliferation | The multiplication or reproduction of cells, resulting in the expansion of a cell population. |
| cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
| regulation of signal transduction by p53 class mediator | Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator. |
| ribosomal large subunit assembly | The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. |
| ribosomal large subunit biogenesis | A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis. |
| rRNA processing | Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04660 | ERB1 | Ribosome biogenesis protein ERB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q7K0Y1 | CG5033 | Ribosome biogenesis protein BOP1 homolog | Drosophila melanogaster (Fruit fly) | PR |
| Q14137 | BOP1 | Ribosome biogenesis protein BOP1 | Homo sapiens (Human) | PR |
| Q562C2 | Bop1 | Ribosome biogenesis protein BOP1 | Rattus norvegicus (Rat) | PR |
| Q9U2A9 | Y48B6A.1 | Ribosome biogenesis protein BOP1 homolog | Caenorhabditis elegans | PR |
| A0JMQ0 | bop1 | Ribosome biogenesis protein bop1 | Danio rerio (Zebrafish) (Brachydanio rerio) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGACGKPHM | SPASLPGKRR | LEPDQELQIQ | EPPLLSDPDS | SLSDSEESVF | SGLEDLGSDS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SEEDTEGVAG | SSGDEDNHRA | EETSEELAQA | APLCSRTEEA | GALAQDEYEE | DSSDEEDIRN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TVGNVPLAWY | DEFPHVGYDL | DGKRIYKPLR | TRDELDQFLD | KMDDPDFWRT | VQDKMTGRDL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RLTDEQVALV | HRLQRGQFGD | SGFNPYEPAV | DFFSGDIMIH | PVTNRPADKR | SFIPSLVEKE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KVSRMVHAIK | MGWIKPRRPH | DPTPSFYDLW | AQEDPNAVLG | RHKMHVPAPK | LALPGHAESY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPPPEYLPTE | EERSAWMQQE | PVERKLNFLP | QKFPSLRTVP | AYSRFIQERF | ERCLDLYLCP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RQRKMRVNVD | PEDLIPKLPR | PRDLQPFPVC | QALVYRGHSD | LVRCLSVSPG | GQWLASGSDD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GTLKLWEVAT | ARCMKTVHVG | GVVRSIAWNP | NPTICLVAAA | MDDAVLLLNP | ALGDRLLVGS |
| 490 | 500 | 510 | 520 | 530 | 540 |
| TDQLLEAFTP | PEEPALQPAR | WLEVSEEEHQ | RGLRLRICHS | KPVTQVTWHG | RGDYLAVVLS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| SQEHTQVLLH | QVSRRRSQSP | FRRSHGQVQC | VAFHPSRPFL | LVASQRSIRI | YHLLRQELTK |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KLMPNCKWVS | SMAVHPAGDN | IICGSYDSKL | VWFDLDLSTK | PYKVLRHHKK | ALRAVAFHPR |
| 670 | 680 | 690 | 700 | 710 | 720 |
| YPLFASGSDD | GSVIVCHGMV | YNDLLQNPLL | VPVKVLKGHT | LTRDLGVLDV | AFHPTQPWVF |
| 730 | |||||
| SSGADGTIRL | FS |