A0JMQ0
Gene name |
bop1 (si:ch211-251g8.4) |
Protein name |
Ribosome biogenesis protein bop1 |
Names |
Block of proliferation 1 protein |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:777627 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for A0JMQ0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-A0JMQ0-F1 | Predicted | AlphaFoldDB |
No variants for A0JMQ0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for A0JMQ0 | |||||
No associated diseases with A0JMQ0
8 regional properties for A0JMQ0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 432 - 513 | IPR001680-1 |
| repeat | WD40 repeat | 554 - 596 | IPR001680-2 |
| repeat | WD40 repeat | 599 - 637 | IPR001680-3 |
| repeat | WD40 repeat | 640 - 679 | IPR001680-4 |
| repeat | WD40 repeat | 683 - 722 | IPR001680-5 |
| repeat | WD40 repeat | 734 - 777 | IPR001680-6 |
| domain | BOP1, N-terminal domain | 174 - 432 | IPR012953 |
| conserved_site | WD40 repeat, conserved site | 458 - 472 | IPR019775 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| PeBoW complex | A protein complex that is involved in coordinating ribosome biogenesis with cell cycle progression. In human, it is composed of Pes1, Bop1, and WDR12; in Saccharomyces the proteins are known as Nop7p, Erb1 and Ytm1 respectively. |
| preribosome, large subunit precursor | A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| ribonucleoprotein complex binding | Binding to a complex of RNA and protein. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. |
| maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript. |
| regulation of cell cycle | Any process that modulates the rate or extent of progression through the cell cycle. |
6 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q04660 | ERB1 | Ribosome biogenesis protein ERB1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q7K0Y1 | CG5033 | Ribosome biogenesis protein BOP1 homolog | Drosophila melanogaster (Fruit fly) | PR |
| Q14137 | BOP1 | Ribosome biogenesis protein BOP1 | Homo sapiens (Human) | PR |
| P97452 | Bop1 | Ribosome biogenesis protein BOP1 | Mus musculus (Mouse) | PR |
| Q562C2 | Bop1 | Ribosome biogenesis protein BOP1 | Rattus norvegicus (Rat) | PR |
| Q9U2A9 | Y48B6A.1 | Ribosome biogenesis protein BOP1 homolog | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKLKNKKRH | LEENEEEQLP | IFDKDSGEDG | HLDDGDEDPA | DLSDSEESVF | SGLEDSGSDD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EDDDEDDDED | DDDKDGSEEK | SSDAEEDKAD | DDDGDLKLSA | KDDVKPQVDS | QNSKEKKKKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RKGKSVLKDG | GEEDVASGRD | EALKITSQVD | EYDHDTSDEE | DIRNTVGNIP | MEWYKDYPHI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GYDLDGKKIF | KPIRNKDELD | EFLDKMENPD | YWRTVQDKMT | GADIRLSDEQ | VDLVHRLQQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KFGDVNFNEY | EPAVDFFSNE | VMIHPVTNRP | QDKRSFIPSL | IEKEKVGKLV | HAIKMGWIKP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RRPKETTPQY | YDLWAKEDPN | SILGRHKMHV | PAPKMKLPGH | EESYNPPPEY | LLSEEERLAW |
| 370 | 380 | 390 | 400 | 410 | 420 |
| AAQDPEDRKL | SFLPQKFSCL | RAVPAFSRFI | HERFERCLDL | YLCPRQRKMR | VNVNPEDLIP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| KLPKPKDLQP | FPTTQSLVYR | GHSSLVRSIS | VSPSGQWLVS | GSDDCTVRFW | EVSTARCLKT |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VQVGGAVKGV | AWNPNPSICL | VAVSYEDSVL | LLNPALGDRL | LCTATDQLIS | SYAEPEEVKE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QPVQWLVSEG | EGHEQGHRLV | LKHPKAVRQV | TWHAKGDYLA | CVLPDSSSSV | QVLIHQVSKR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RTQNPFRKSK | GLVQCVSFHP | VRPYFFVATQ | RYVRVYNLIK | QELTKKLMAN | CKWISSMAIH |
| 670 | 680 | 690 | 700 | 710 | 720 |
| PGGDNVICGS | YDCRLAWFDL | DLSTKPYKVL | RHHKKALRSV | SFHSHYPLLA | SGSDDGSVIV |
| 730 | 740 | 750 | 760 | 770 | |
| CHGMVYNDLL | QNPLIVPVKV | LKGHSITHDL | GVLDVTFHPT | QPWVFSSGAD | ATIRLYT |