AiPD: Autoinhibited Protein Database

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

203-289 (Predicted disordered autoinhibitory region) PR

203-289 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
8DDD	NMR	-	B	268-298	PDB
AF-Q01114-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3389153846	2	A>*	No	EVA
rs3389146678	2	A>V	No	EVA
rs243382053	8	A>V	No	EVA
rs232950109	17	A>T	No	EVA
rs260186884	29	W>C	No	EVA
rs254366318	38	V>I	No	EVA
rs3401818634	50	A>D	No	EVA
rs251913050	52	A>T	No	EVA
rs48507356	68	S>L	No	EVA
rs3389086833	75	E>V	No	EVA
rs214433136	88	T>A	No	EVA
rs47492407	91	K>N	No	EVA
rs238816843	95	T>I	No	EVA
rs3389120627	96	F>I	No	EVA
rs3389146666	120	T>R	No	EVA
rs3389148068	123	R>C	No	EVA
rs231914282	156	V>I	No	EVA
rs3389149450	167	I>T	No	EVA
rs50540382	179	S>N	No	EVA
rs3389144164	185	K>M	No	EVA
rs3389146668	189	E>*	No	EVA
rs3389149405	194	R>G	No	EVA
rs224243234	200	V>F	No	EVA
rs3389145403	201	G>R	No	EVA
rs261022887	210	V>I	No	EVA
rs249160717	217	I>V	No	EVA
rs108334533	227	T>S	No	EVA
rs46823302	230	S>R	No	EVA
rs3402303052	236	E>Q	No	EVA
rs3389135656	239	Y>F	No	EVA
rs3389140561	247	W>L	No	EVA
rs49750132	259	R>T	No	EVA
rs3389120611	268	Q>K	No	EVA
rs240904033	276	V>I	No	EVA
rs3411452391	277	V>M	No	EVA
rs254063050	289	L>I	No	EVA
rs3389086797	292	K>T	No	EVA
rs29461035	297	L>V	No	EVA
rs262257140	305	I>T	No	EVA
rs265162327	325	S>T	No	EVA
rs246861519	330	R>H	No	EVA
rs3389157049	351	S>N	No	EVA
rs226922170	356	V>I	No	EVA
rs3389140619	383	G>E	No	EVA
rs229369086	384	L>P	No	EVA
rs260557177	393	A>T	No	EVA
rs241037623	450	E>Q	No	EVA
rs3389120688	464	V>M	No	EVA
rs3402116826	466	S>R	No	EVA

Type	Name	Position	InterPro Accession
conserved_site	Short hematopoietin receptor, family 1, conserved site	212 - 253	IPR003531
domain	Fibronectin type III	147 - 256	IPR003961

		Description
EC Number
Subcellular Localization	Cell membrane; Single-pass type I membrane protein Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cell surface	The external part of the cell wall and/or plasma membrane.
external side of plasma membrane	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral component of membrane	The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
cytokine receptor activity	Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
interleukin-9 binding	Binding to interleukin-9.
interleukin-9 receptor activity	Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

Name	Definition
B cell differentiation	The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
B cell proliferation	The expansion of a B cell population by cell division. Follows B cell activation.
cytokine-mediated signaling pathway	The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
immunoglobulin mediated immune response	An immune response mediated by immunoglobulins, whether cell-bound or in solution.
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	Any process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway.
positive regulation of cell growth	Any process that activates or increases the frequency, rate, extent or direction of cell growth.
regulation of peptidyl-tyrosine phosphorylation	Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P14753	Epor	Erythropoietin receptor	Mus musculus (Mouse)	PR
Q08351	Mpl	Thrombopoietin receptor	Mus musculus (Mouse)	PR
P26954	Csf2rb2	Interleukin-3 receptor class 2 subunit beta	Mus musculus (Mouse)	PR
P26955	Csf2rb	Cytokine receptor common subunit beta	Mus musculus (Mouse)	PR