P26954
PR
Gene name |
Csf2rb2 (Ai2ca, Il3r, Il3rb2) |
Protein name |
Interleukin-3 receptor class 2 subunit beta |
Names |
IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA, Interleukin-3 receptor class II alpha chain, IL-3 receptor class 2 subunit beta, IL-3R class 2 subunit beta, Colony-stimulating factor 2 receptor subunit beta-2, Interleukin-3 receptor class II beta chain |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12984 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P26954
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4QQV | X-ray | 345 A | A/B/C/D | 23-438 | PDB |
| AF-P26954-F1 | Predicted | AlphaFoldDB |
90 variants for P26954
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs31526769 | 6 | A>T | No | EVA | |
| rs3389364530 | 8 | T>K | No | EVA | |
| rs578868725 | 18 | A>T | No | EVA | |
| rs234722002 | 28 | E>A | No | EVA | |
| rs3389386298 | 37 | L>M | No | EVA | |
| rs31524721 | 38 | E>Q | No | EVA | |
| rs3389372590 | 39 | C>Y | No | EVA | |
| rs586785979 | 45 | N>S | No | EVA | |
| rs583529437 | 46 | R>H | No | EVA | |
| rs3389364565 | 47 | I>T | No | EVA | |
| rs31524717 | 71 | D>E | No | EVA | |
| rs31527847 | 83 | K>E | No | EVA | |
| rs3389386338 | 87 | S>A | No | EVA | |
| rs3389361748 | 114 | Y>* | No | EVA | |
| rs108610797 | 139 | P>L | No | EVA | |
| rs259650908 | 142 | D>N | No | EVA | |
| rs240586100 | 143 | I>V | No | EVA | |
| rs221203346 | 144 | H>N | No | EVA | |
| rs262708373 | 144 | H>R | No | EVA | |
| rs237013238 | 148 | S>A | No | EVA | |
| rs222086975 | 157 | S>N | No | EVA | |
| rs3389323272 | 188 | D>E | No | EVA | |
| rs582799097 | 190 | S>Y | No | EVA | |
| rs31524357 | 201 | L>F | No | EVA | |
| rs31524355 | 213 | A>V | No | EVA | |
| rs229496016 | 222 | A>P | No | EVA | |
| rs229496016 | 222 | A>T | No | EVA | |
| rs3389364532 | 229 | R>K | No | EVA | |
| rs3413120386 | 238 | H>Y | No | EVA | |
| rs3389351834 | 244 | G>R | No | EVA | |
| rs3389374220 | 249 | P>S | No | EVA | |
| rs3389372639 | 266 | W>* | No | EVA | |
| rs3389365786 | 266 | W>R | No | EVA | |
| rs587434742 | 297 | V>A | No | EVA | |
| rs3389368638 | 299 | E>D | No | EVA | |
| rs1132585135 | 304 | V>I | No | EVA | |
| rs254237490 | 309 | R>H | No | EVA | |
| rs3389340253 | 347 | P>L | No | EVA | |
| rs262770025 | 348 | I>T | No | EVA | |
| rs31528191 | 351 | Q>L | No | EVA | |
| rs253775905 | 353 | K>N | No | EVA | |
| rs1133130567 | 361 | H>Y | No | EVA | |
| rs31528189 | 363 | E>K | No | EVA | |
| rs3406011966 | 377 | V>L | No | EVA | |
| rs224320780 | 398 | N>H | No | EVA | |
| rs3389372596 | 399 | S>N | No | EVA | |
| rs247315434 | 410 | S>T | No | EVA | |
| rs3389291008 | 411 | Y>* | No | EVA | |
| rs3389368668 | 413 | A>T | No | EVA | |
| rs230996725 | 434 | Y>H | No | EVA | |
| rs3389380462 | 437 | T>K | No | EVA | |
| rs1133836370 | 444 | T>M | No | EVA | |
| rs107799188 | 456 | F>L | No | EVA | |
| rs3389372593 | 505 | F>I | No | EVA | |
| rs583823629 | 529 | E>A | No | EVA | |
| rs237084340 | 535 | N>D | No | EVA | |
| rs580064555 | 536 | V>L | No | EVA | |
| rs585956124 | 548 | R>Q | No | EVA | |
| rs578536235 | 551 | P>T | No | EVA | |
| rs31524102 | 553 | R>G | No | EVA | |
| rs585409962 | 571 | V>I | No | EVA | |
| rs581666739 | 574 | E>K | No | EVA | |
| rs31524101 | 577 | I>T | No | EVA | |
| rs3389290995 | 607 | L>P | No | EVA | |
| rs579306555 | 609 | G>D | No | EVA | |
| rs3389364605 | 610 | Q>H | No | EVA | |
| rs585125366 | 614 | P>S | No | EVA | |
| rs581465571 | 618 | G>R | No | EVA | |
| rs108137268 | 619 | S>N | No | EVA | |
| rs3389291011 | 647 | V>M | No | EVA | |
| rs1131825274 | 683 | E>D | No | EVA | |
| rs3389372622 | 685 | Q>* | No | EVA | |
| rs584724439 | 692 | M>T | No | EVA | |
| rs31524095 | 692 | M>V | No | EVA | |
| rs31577888 | 703 | G>D | No | EVA | |
| rs3389340276 | 728 | S>Y | No | EVA | |
| rs3389361801 | 761 | G>W | No | EVA | |
| rs3389380419 | 771 | S>T | No | EVA | |
| rs581007220 | 775 | A>T | No | EVA | |
| rs239391925 | 777 | T>K | No | EVA | |
| rs3389364589 | 790 | S>R | No | EVA | |
| rs3389364569 | 848 | E>D | No | EVA | |
| rs583116599 | 850 | L>P | No | EVA | |
| rs3389370761 | 852 | Q>H | No | EVA | |
| rs3389340243 | 858 | K>R | No | EVA | |
| rs3389372582 | 867 | A>V | No | EVA | |
| rs3389365739 | 868 | P>L | No | EVA | |
| rs3389386274 | 869 | A>S | No | EVA | |
| rs580535245 | 878 | Y>H | No | EVA | |
| rs3389386281 | 879 | Y>R | No | EVA |
No associated diseases with P26954
5 regional properties for P26954
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Short hematopoietin receptor, family 1, conserved site | 405 - 436 | IPR003531 |
| domain | Fibronectin type III | 137 - 244 | IPR003961-1 |
| domain | Fibronectin type III | 343 - 438 | IPR003961-2 |
| domain | Growth hormone/erythropoietin receptor, ligand binding | 247 - 336 | IPR015152 |
| domain | Interferon/interleukin receptor domain | 367 - 431 | IPR015373 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| external side of plasma membrane | The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. |
| granulocyte macrophage colony-stimulating factor receptor complex | The heterodimeric receptor for granulocyte macrophage colony-stimulating factor. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cytokine receptor activity | Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cytokine-mediated signaling pathway | The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| granulocyte-macrophage colony-stimulating factor signaling pathway | The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors. |
| immunoglobulin mediated immune response | An immune response mediated by immunoglobulins, whether cell-bound or in solution. |
| positive regulation of leukocyte proliferation | Any process that activates or increases the frequency, rate or extent of leukocyte proliferation. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| receptor signaling pathway via JAK-STAT | Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P26955 | Csf2rb | Cytokine receptor common subunit beta | Mus musculus (Mouse) | PR |
| P14753 | Epor | Erythropoietin receptor | Mus musculus (Mouse) | PR |
| Q08351 | Mpl | Thrombopoietin receptor | Mus musculus (Mouse) | PR |
| Q01114 | Il9r | Interleukin-9 receptor | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDQQMALTWG | LCYMALVALC | WGHEVTEEEE | TVPLKTLECY | NDYTNRIICS | WADTEDAQGL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| INMTLLYHQL | DKIQSVSCEL | SEKLMWSECP | SSHRCVPRRC | VIPYTRFSNG | DNDYYSFQPD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RDLGIQLMVP | LAQHVQPPPP | KDIHISPSGD | HFLLEWSVSL | GDSQVSWLSS | KDIEFEVAYK |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RLQDSWEDAS | SLHTSNFQVN | LEPKLFLPNS | IYAARVRTRL | SAGSSLSGRP | SRWSPEVHWD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SQPGDKAQPQ | NLQCFFDGIQ | SLHCSWEVWT | QTTGSVSFGL | FYRPSPAAPE | EKCSPVVKEP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QASVYTRYRC | SLPVPEPSAH | SQYTVSVKHL | EQGKFIMSYY | HIQMEPPILN | QTKNRDSYSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HWETQKIPKY | IDHTFQVQYK | KKSESWKDSK | TENLGRVNSM | DLPQLEPDTS | YCARVRVKPI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SDYDGIWSEW | SNEYTWTTDW | VMPTLWIVLI | LVFLIFTLLL | ALHFGRVYGY | RTYRKWKEKI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PNPSKSLLFQ | DGGKGLWPPG | SMAAFATKNP | ALQGPQSRLL | AEQQGVSYEH | LEDNNVSPLT |
| 550 | 560 | 570 | 580 | 590 | 600 |
| IEDPNIIRDP | PSRPDTTPAA | SSESTEQLPN | VQVEGPIPSS | RPRKQLPSFD | FNGPYLGPPQ |
| 610 | 620 | 630 | 640 | 650 | 660 |
| SHSLPDLPGQ | LGSPQVGGSL | KPALPGSLEY | MCLPPGGQVQ | LVPLSQVMGQ | GQAMDVQCGS |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SLETTGSPSV | EPKENPPVEL | SVEKQEARDN | PMTLPISSGG | PEGSMMASDY | VTPGDPVLTL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| PTGPLSTSLG | PSLGLPSAQS | PSLCLKLPRV | PSGSPALGPP | GFEDYVELPP | SVSQAATSPP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| GHPAPPVASS | PTVIPGEPRE | EVGPASPHPE | GLLVLQQVGD | YCFLPGLGPG | SLSPHSKPPS |
| 850 | 860 | 870 | |||
| PSLCSETEDL | DQDLSVKKFP | YQPLPQAPAI | QFFKSLKY |