P26955

PR
Gene name
Csf2rb (Aic2b, Csf2rb1, Il3rb1)
Protein name
Cytokine receptor common subunit beta
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:12983
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

191-268 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P26955

Entry ID Method Resolution Chain Position Source
AF-P26955-F1 Predicted AlphaFoldDB

79 variants for P26955

Variant ID(s) Position Change Description Diseaes Association Provenance
rs31533031 6 A>T No EVA
rs3389386367 23 H>Q No EVA
rs31533972 38 Q>E No EVA
rs255511892 45 N>S No EVA
rs3389334835 57 A>T No EVA
rs216126985 58 Q>K No EVA
rs31534874 70 E>D No EVA
rs31529514 82 E>K No EVA
rs3389334853 99 C>S No EVA
rs258236839 117 R>Q No EVA
rs227272216 120 S>R No EVA
rs1134445373 123 G>D No EVA
rs3389372642 125 Q>K No EVA
rs3389386284 129 P>S No EVA
rs238086433 138 L>P No EVA
rs232187082 156 S>N No EVA
rs3389370793 157 V>M No EVA
rs3389377936 189 Y>H No EVA
rs584373397 189 Y>S No EVA
rs587158032 195 K>N No EVA
rs31531884 200 F>L No EVA
rs31531886 212 A>V No EVA
rs864284270 221 P>A No EVA
rs864284270 221 P>T No EVA
rs3389372562 239 D>Y No EVA
rs3389374290 250 N>S No EVA
rs213287174 286 V>A No EVA
rs3389372644 287 A>S No EVA
rs252150454 309 H>R No EVA
rs3389374236 334 K>E No EVA
rs3389365771 348 T>N No EVA
rs3389334841 357 S>I No EVA
rs3389323259 368 A>V No EVA
rs3389334887 369 Y>* No EVA
rs3389334863 377 Q>H No EVA
rs231397798 413 C>S No EVA
rs217013011 419 K>M No EVA
rs3389351823 432 S>R No EVA
rs3389370798 438 K>R No EVA
rs583731528 445 T>M No EVA
rs3389377940 460 L>P No EVA
rs3389377871 464 R>H No EVA
rs263743658 469 S>Y No EVA
rs3389372570 496 G>V No EVA
rs226335992 527 E>V No EVA
rs3389369568 531 H>Q No EVA
rs242946859 536 N>D No EVA
rs585973243 549 R>Q No EVA
rs256228305 550 V>D No EVA
rs218747510 551 P>S No EVA
rs238756533 552 P>T No EVA
rs582301067 576 G>E No EVA
rs3389380399 608 P>T No EVA
rs580206355 609 D>G No EVA
rs3406343434 622 P>A No EVA
rs3389369603 632 C>F No EVA
rs3389374262 638 Q>* No EVA
rs580602088 665 S>T No EVA
rs3389323300 681 S>R No EVA
rs3389374278 682 M>K No EVA
rs3389290979 689 D>V No EVA
rs3389374294 691 P>L No EVA
rs581009038 701 P>S No EVA
rs4230844 703 G>D No EVA
rs3389377909 708 S>Y No EVA
rs3389366802 716 P>Q No EVA
rs584581671 736 P>S No EVA
rs586744229 741 P>S No EVA
rs4230845 742 S>R No EVA
rs581311701 743 L>P No EVA
rs582953538 783 P>L No EVA
rs584292076 784 A>V No EVA
rs3389323244 789 S>N No EVA
rs3389341769 837 K>N No EVA
rs1135208942 838 P>L No EVA
rs231639694 851 V>D No EVA
rs263870294 863 P>S No EVA
rs3389366778 866 Q>L No EVA
rs3406644045 887 W>R No EVA

No associated diseases with P26955

5 regional properties for P26955

Type Name Position InterPro Accession
conserved_site Short hematopoietin receptor, family 1, conserved site 406 - 437 IPR003531
domain Fibronectin type III 136 - 243 IPR003961-1
domain Fibronectin type III 343 - 439 IPR003961-2
domain Growth hormone/erythropoietin receptor, ligand binding 246 - 337 IPR015152
domain Interferon/interleukin receptor domain 343 - 431 IPR015373

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
external side of plasma membrane The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
granulocyte macrophage colony-stimulating factor receptor complex The heterodimeric receptor for granulocyte macrophage colony-stimulating factor.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

1 GO annotations of molecular function

Name Definition
cytokine receptor activity Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

7 GO annotations of biological process

Name Definition
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
granulocyte-macrophage colony-stimulating factor signaling pathway The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors.
immunoglobulin mediated immune response An immune response mediated by immunoglobulins, whether cell-bound or in solution.
positive regulation of leukocyte proliferation Any process that activates or increases the frequency, rate or extent of leukocyte proliferation.
protein phosphorylation The process of introducing a phosphate group on to a protein.
receptor signaling pathway via JAK-STAT Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
regulation of cell growth Any process that modulates the frequency, rate, extent or direction of cell growth.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P26954 Csf2rb2 Interleukin-3 receptor class 2 subunit beta Mus musculus (Mouse) PR
P14753 Epor Erythropoietin receptor Mus musculus (Mouse) PR
Q08351 Mpl Thrombopoietin receptor Mus musculus (Mouse) PR
Q01114 Il9r Interleukin-9 receptor Mus musculus (Mouse) PR
10 20 30 40 50 60
MDQQMALTWG LCYMALVALC WGHGVTEAEE TVPLKTLQCY NDYTNHIICS WADTEDAQGL
70 80 90 100 110 120
INMTLYHQLE KKQPVSCELS EELMWSECPS SHRCVPRRCV IPYTRFSITN EDYYSFRPDS
130 140 150 160 170 180
DLGIQLMVPL AQNVQPPLPK NVSISSSEDR FLLEWSVSLG DAQVSWLSSK DIEFEVAYKR
190 200 210 220 230 240
LQDSWEDAYS LHTSKFQVNF EPKLFLPNSI YAARVRTRLS PGSSLSGRPS RWSPEVHWDS
250 260 270 280 290 300
QPGDKAQPQN LQCFFDGIQS LHCSWEVWTQ TTGSVSFGLF YRPSPVAPEE KCSPVVKEPP
310 320 330 340 350 360
GASVYTRYHC SLPVPEPSAH SQYTVSVKHL EQGKFIMSYN HIQMEPPTLN LTKNRDSYSL
370 380 390 400 410 420
HWETQKMAYS FIEHTFQVQY KKKSDSWEDS KTENLDRAHS MDLSQLEPDT SYCARVRVKP
430 440 450 460 470 480
ISNYDGIWSK WSEEYTWKTD WVMPTLWIVL ILVFLILTLL LILRFGCVSV YRTYRKWKEK
490 500 510 520 530 540
IPNPSKSLLF QDGGKGLWPP GSMAAFATKN PALQGPQSRL LAEQQGESYA HLEDNNVSPL
550 560 570 580 590 600
TIEDPNIIRV PPSGPDTTPA ASSESTEQLP NVQVEGPTPN RPRKQLPSFD FNGPYLGPPQ
610 620 630 640 650 660
SHSLPDLPDQ LGSPQVGGSL KPALPGSLEY MCLPPGGQAQ LVPLSQVMGQ GQAMDVQCGS
670 680 690 700 710 720
SLETSGSPSV EPKENPPVEL SMEEQEARDN PVTLPISSGG PEGSMMASDY VTPGDPVLTL
730 740 750 760 770 780
PTGPLSTSLG PSLGLPSAQS PSLCLKLPRV PSGSPALGPP GFEDYVELPP SVSQAAKSPP
790 800 810 820 830 840
GHPAPPVASS PTVIPGEPRE EVGPASPHPE GLLVLQQVGD YCFLPGLGPG SLSPHSKPPS
850 860 870 880 890
PSLCSETEDL VQDLSVKKFP YQPMPQAPAI QFFKSLKHQD YLSLPPWDNS QSGKVC