P97711
Gene name |
Grk6 (Gprk6) |
Protein name |
G protein-coupled receptor kinase 6 |
Names |
EC 2.7.11.16 , G protein-coupled receptor kinase GRK6 |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
|
EC number |
2.7.11.16: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
186-448 (Protein kinase domain) |
Relief mechanism |
PTM |
Assay |
|
Accessory elements
No accessory elements
References
- Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell systems, 2, 89-100
- Pronin AN et al. (1998) "Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation", The Journal of biological chemistry, 273, 31510-8
- Vatter P et al. (2005) "The variable C-terminal extension of G-protein-coupled receptor kinase 6 constitutes an accessorial autoregulatory domain", The FEBS journal, 272, 6039-51
Autoinhibited structure
Activated structure
1 structures for P97711
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P97711-F1 | Predicted | AlphaFoldDB |
No variants for P97711
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P97711 | |||||
No associated diseases with P97711
5 regional properties for P97711
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 186 - 448 | IPR000719 |
| domain | AGC-kinase, C-terminal | 449 - 528 | IPR000961 |
| active_site | Serine/threonine-protein kinase, active site | 307 - 319 | IPR008271 |
| domain | RGS domain | 52 - 171 | IPR016137 |
| binding_site | Protein kinase, ATP binding site | 192 - 224 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.16 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| beta-adrenergic receptor kinase activity | Catalysis of the reaction |
| G protein-coupled receptor kinase activity | Catalysis of the reaction |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to lipopolysaccharide | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. |
| desensitization of G protein-coupled receptor signaling pathway | The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway. |
| phosphorylation | The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. |
| regulation of signal transduction | Any process that modulates the frequency, rate or extent of signal transduction. |
| Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. |
20 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P26818 | GRK3 | Beta-adrenergic receptor kinase 2 | Bos taurus (Bovine) | PR |
| P43249 | GRK5 | G protein-coupled receptor kinase 5 | Bos taurus (Bovine) | SS |
| P21146 | GRK2 | Beta-adrenergic receptor kinase 1 | Bos taurus (Bovine) | PR |
| P32865 | Gprk1 | G protein-coupled receptor kinase 1 | Drosophila melanogaster (Fruit fly) | PR |
| P25098 | GRK2 | Beta-adrenergic receptor kinase 1 | Homo sapiens (Human) | PR |
| P35626 | GRK3 | Beta-adrenergic receptor kinase 2 | Homo sapiens (Human) | PR |
| Q15835 | GRK1 | Rhodopsin kinase GRK1 | Homo sapiens (Human) | PR |
| P34947 | GRK5 | G protein-coupled receptor kinase 5 | Homo sapiens (Human) | EV |
| P32298 | GRK4 | G protein-coupled receptor kinase 4 | Homo sapiens (Human) | SS |
| P43250 | GRK6 | G protein-coupled receptor kinase 6 | Homo sapiens (Human) | EV |
| Q8VEB1 | Grk5 | G protein-coupled receptor kinase 5 | Mus musculus (Mouse) | SS |
| Q99MK8 | Grk2 | Beta-adrenergic receptor kinase 1 | Mus musculus (Mouse) | PR |
| Q9WVL4 | Grk1 | Rhodopsin kinase GRK1 | Mus musculus (Mouse) | PR |
| Q3UYH7 | Adrbk2 | Beta-adrenergic receptor kinase 2 | Mus musculus (Mouse) | PR |
| O70293 | Grk6 | G protein-coupled receptor kinase 6 | Mus musculus (Mouse) | SS |
| P26817 | Grk2 | Beta-adrenergic receptor kinase 1 | Rattus norvegicus (Rat) | PR |
| Q62833 | Grk5 | G protein-coupled receptor kinase 5 | Rattus norvegicus (Rat) | SS |
| P26819 | Grk3 | Beta-adrenergic receptor kinase 2 | Rattus norvegicus (Rat) | PR |
| Q09639 | grk-2 | G protein-coupled receptor kinase 2 | Caenorhabditis elegans | PR |
| O48963 | PHOT1 | Phototropin-1 | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELENIVANT | VLLKAREGGG | GNRKGKSKKW | RQMLQFPHIS | QCEELRLSLE | RDYHSLCERQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PIGRLLFREF | CATRPELTRC | TAFLDGVAEY | EVTPDEKRKA | CGCRLMQNFL | SHTGPDLIPE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VPRQLVSNCA | QRLEQGPCKD | LFQELTRLTH | EYLSMAPFAD | YLDSIYFNRF | LQWKWLERQP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VTKNTFRQYR | VLGKGGFGEV | CACQVRATGK | MYACKKLEKK | RIKKRKGEAM | ALNEKQILEK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VNSRFVVSLA | YAYETKDALC | LVLTLMNGGD | LKFHIYHMGQ | AGFPEARAVF | YAAEICCGLE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DLHRERIVYR | DLKPENILLD | DHGHIRISDL | GLTVHVPEGQ | TIKGRVGTVG | YMAPEVVKNE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RYTFSPDWWA | LGCLLYEMIA | GQSPFQQRKK | KIKREEVERL | VKEVAEEYTD | RFSPQARSLC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SQLPNKDPAE | RLGCRGGGAR | EVKEHPLFKK | LNFKRLGAGM | LEPPFKPDPQ | AIYCKDVLDI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EQFSTVKGVD | LEPTDQDFYQ | KFATGSVSIP | WQNEMVETEC | FQELNVFGLD | GSVPPDLDWK |
| 550 | 560 | 570 | |||
| GQPTAPPKKG | LLQRLFSRQD | CCGNCSDSEE | ELPTRL |