P32865
PR
Gene name |
Gprk1 (Gprk-1, CG40129) |
Protein name |
G protein-coupled receptor kinase 1 |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG40129 |
EC number |
2.7.11.16: Protein-serine/threonine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P32865
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P32865-F1 | Predicted | AlphaFoldDB |
No variants for P32865
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P32865 | |||||
No associated diseases with P32865
6 regional properties for P32865
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Protein kinase domain | 191 - 454 | IPR000719 |
| domain | AGC-kinase, C-terminal | 455 - 531 | IPR000961 |
| domain | Pleckstrin homology domain | 557 - 659 | IPR001849 |
| active_site | Serine/threonine-protein kinase, active site | 314 - 326 | IPR008271 |
| domain | RGS domain | 54 - 175 | IPR016137 |
| binding_site | Protein kinase, ATP binding site | 197 - 220 | IPR017441 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.11.16 | Protein-serine/threonine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
6 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| G protein-coupled receptor binding | Binding to a G protein-coupled receptor. |
| G protein-coupled receptor kinase activity | Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate. |
| phosphatidylinositol binding | Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. |
| protein kinase activity | Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. |
| rhodopsin kinase activity | Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| metarhodopsin inactivation | The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it. |
| phototransduction, visible light | The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm. |
| positive regulation of smoothened signaling pathway | Any process that activates or increases the frequency, rate or extent of smoothened signaling. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
| regulation of signal transduction | Any process that modulates the frequency, rate or extent of signal transduction. |
19 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P43249 | GRK5 | G protein-coupled receptor kinase 5 | Bos taurus (Bovine) | SS |
| P21146 | GRK2 | Beta-adrenergic receptor kinase 1 | Bos taurus (Bovine) | PR |
| P26818 | GRK3 | Beta-adrenergic receptor kinase 2 | Bos taurus (Bovine) | PR |
| Q15835 | GRK1 | Rhodopsin kinase GRK1 | Homo sapiens (Human) | PR |
| P34947 | GRK5 | G protein-coupled receptor kinase 5 | Homo sapiens (Human) | EV |
| P32298 | GRK4 | G protein-coupled receptor kinase 4 | Homo sapiens (Human) | SS |
| P43250 | GRK6 | G protein-coupled receptor kinase 6 | Homo sapiens (Human) | EV |
| P25098 | GRK2 | Beta-adrenergic receptor kinase 1 | Homo sapiens (Human) | PR |
| P35626 | GRK3 | Beta-adrenergic receptor kinase 2 | Homo sapiens (Human) | PR |
| O70293 | Grk6 | G protein-coupled receptor kinase 6 | Mus musculus (Mouse) | SS |
| Q8VEB1 | Grk5 | G protein-coupled receptor kinase 5 | Mus musculus (Mouse) | SS |
| Q9WVL4 | Grk1 | Rhodopsin kinase GRK1 | Mus musculus (Mouse) | PR |
| Q3UYH7 | Adrbk2 | Beta-adrenergic receptor kinase 2 | Mus musculus (Mouse) | PR |
| Q99MK8 | Grk2 | Beta-adrenergic receptor kinase 1 | Mus musculus (Mouse) | PR |
| Q62833 | Grk5 | G protein-coupled receptor kinase 5 | Rattus norvegicus (Rat) | SS |
| P97711 | Grk6 | G protein-coupled receptor kinase 6 | Rattus norvegicus (Rat) | SS |
| P26819 | Grk3 | Beta-adrenergic receptor kinase 2 | Rattus norvegicus (Rat) | PR |
| P26817 | Grk2 | Beta-adrenergic receptor kinase 1 | Rattus norvegicus (Rat) | PR |
| Q09639 | grk-2 | G protein-coupled receptor kinase 2 | Caenorhabditis elegans | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADLEAVLAD | VSYLMAMEKS | KCTPAARASK | KLNLPDPSVR | SVMYKYLEKE | GELNFHKIFN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EVLGYLLFKD | FCENDSEEPI | QQLKFFEQIK | LFEKTECYDE | RKKMARDIYD | NFIMEEMLSH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TYEYSKHAVA | SVQKYLLKNE | VPVDLFEPYL | EEIFTQLKGK | PFKKFLESDK | FTRFCQWKNL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ELNIQLTMND | FSVHRIIGRG | GFGEVYGCRK | ADTGKMYAMK | CLDKKRIKMK | QGEMLALNER |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NMLQAVSTGI | DCPFIVCMTY | AFHTPDKLCF | ILDLMNGGDL | HYHLSQHGIF | SEDEMKFYAA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EVILGLEHMH | KRCIVYRDLK | PANILLDENG | HIRISDLGLA | CDFSKKKPHA | SVGTHGYMAP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EVLSKGTSYD | SCADWFSFGC | MLYKLLKGHS | PFRQHKTKDK | LEIDKMTLTM | NVELPESFSL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| ELKNLLEMLL | QRDVSKRLGC | MGNGADEVKM | HNFFCGIDWH | QVYIQKYTPP | LVPPRGEVNA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ADAFDIGSFD | EEDTKGIKLN | DADQDLYKMF | SLTISERWQQ | EVSETVFDTV | NTETDKLEQK |
| 550 | 560 | 570 | 580 | 590 | 600 |
| RKLKQKQHFD | ADEKESDCIL | HGYIKKLGGS | FASLWQTKYA | KLYPNRLELH | SESGNNKPEL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| IFMDQVEDIS | SDFILHKNEN | CIQIRINDGT | RDGRIILTNS | DEIGLKEWSS | SLRSAHKISQ |
| 670 | 680 | 690 | |||
| DLLGSMAKKA | GKIYGSERDV | NKSMYIFGGN | CSTKTSNGSN |