O70293

SS
Gene name
Grk6 (Gprk6)
Protein name
G protein-coupled receptor kinase 6
Names
EC 2.7.11.16 , G protein-coupled receptor kinase GRK6
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:26385
EC number
2.7.11.16: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

557-576 (C-terminal extension) SS

Target domain

186-448 (Protein kinase domain)

Relief mechanism

PTM

Assay

Accessory elements

328-350 (Activation loop from InterPro)

Target domain

186-448 (Protein kinase domain)

Relief mechanism

Assay

328-350 (Activation loop from InterPro)

Target domain

186-448 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for O70293

Entry ID Method Resolution Chain Position Source
AF-O70293-F1 Predicted AlphaFoldDB

26 variants for O70293

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389268868 23 R>P No EVA
rs3389242995 24 K>R No EVA
rs3389296544 46 R>* No EVA
rs253254570 48 S>I No EVA
rs3389242982 53 Y>* No EVA
rs3410333668 64 R>G No EVA
rs3389296591 67 F>L No EVA
rs3389268808 80 C>S No EVA
rs3389287927 117 L>F No EVA
rs3389252602 138 C>W No EVA
rs3389296597 197 F>L No EVA
rs3389278258 219 K>R No EVA
rs3389287880 254 E>D No EVA
rs3389284726 261 L>M No EVA
rs3389299860 282 G>R No EVA
rs3389296542 309 Y>F No EVA
rs3389292322 404 V>M No EVA
rs3389284704 414 S>* No EVA
rs29243709 417 R>C No EVA
rs29243709 417 R>S No EVA
rs3389242962 447 L>H No EVA
rs3404206779 500 Q>* No EVA
rs3389259910 500 Q>H No EVA
rs3389286743 509 I>T No EVA
rs3389292345 546 P>S No EVA
rs3389299832 571 E>K No EVA

No associated diseases with O70293

5 regional properties for O70293

Type Name Position InterPro Accession
domain Protein kinase domain 186 - 448 IPR000719
domain AGC-kinase, C-terminal 449 - 528 IPR000961
active_site Serine/threonine-protein kinase, active site 307 - 319 IPR008271
domain RGS domain 52 - 171 IPR016137
binding_site Protein kinase, ATP binding site 192 - 224 IPR017441

Functions

Description
EC Number 2.7.11.16 Protein-serine/threonine kinases
Subcellular Localization
  • Membrane; Lipid-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
beta-adrenergic receptor kinase activity Catalysis of the reaction
G protein-coupled receptor kinase activity Catalysis of the reaction

4 GO annotations of biological process

Name Definition
desensitization of G protein-coupled receptor signaling pathway The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
regulation of signal transduction Any process that modulates the frequency, rate or extent of signal transduction.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

18 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P26818 GRK3 Beta-adrenergic receptor kinase 2 Bos taurus (Bovine) PR
P43249 GRK5 G protein-coupled receptor kinase 5 Bos taurus (Bovine) SS
P21146 GRK2 Beta-adrenergic receptor kinase 1 Bos taurus (Bovine) PR
P32865 Gprk1 G protein-coupled receptor kinase 1 Drosophila melanogaster (Fruit fly) PR
P25098 GRK2 Beta-adrenergic receptor kinase 1 Homo sapiens (Human) PR
P35626 GRK3 Beta-adrenergic receptor kinase 2 Homo sapiens (Human) PR
Q15835 GRK1 Rhodopsin kinase GRK1 Homo sapiens (Human) PR
P34947 GRK5 G protein-coupled receptor kinase 5 Homo sapiens (Human) EV
P32298 GRK4 G protein-coupled receptor kinase 4 Homo sapiens (Human) SS
P43250 GRK6 G protein-coupled receptor kinase 6 Homo sapiens (Human) EV
Q8VEB1 Grk5 G protein-coupled receptor kinase 5 Mus musculus (Mouse) SS
Q99MK8 Grk2 Beta-adrenergic receptor kinase 1 Mus musculus (Mouse) PR
Q3UYH7 Adrbk2 Beta-adrenergic receptor kinase 2 Mus musculus (Mouse) PR
Q9WVL4 Grk1 Rhodopsin kinase GRK1 Mus musculus (Mouse) PR
Q62833 Grk5 G protein-coupled receptor kinase 5 Rattus norvegicus (Rat) SS
P26817 Grk2 Beta-adrenergic receptor kinase 1 Rattus norvegicus (Rat) PR
P97711 Grk6 G protein-coupled receptor kinase 6 Rattus norvegicus (Rat) SS
Q09639 grk-2 G protein-coupled receptor kinase 2 Caenorhabditis elegans PR
10 20 30 40 50 60
MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ
70 80 90 100 110 120
PIGRLLFREF CATRPELTRC TAFLDGVSEY EVTPDEKRKA CGRRLMQNFL SHTGPDLIPE
130 140 150 160 170 180
VPRQLVSNCA QRLEQGPCKD LFQELTRLTH EYLSTAPFAD YLDSIYFNRF LQWKWLERQP
190 200 210 220 230 240
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK
250 260 270 280 290 300
VNSRFVVSLA YAYETKDALC LVLTLMNGGD LKFHIYHMGQ AGFPEARAVF YAAEICCGLE
310 320 330 340 350 360
DLHRERIVYR DLKPENILLD DHGHIRISDL GLAVHVPEGQ TIKGRVGTVG YMAPEVVRNE
370 380 390 400 410 420
RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK KIKREEVERL VKEVAEEYTD RFSSQARSLC
430 440 450 460 470 480
SQLLSKDPAE RLGCRGGGAR EVKEHPLFKK LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI
490 500 510 520 530 540
EQFSTVKGVD LEPTDQDFYQ KFATGSVSIP WQNEMVETEC FQELNVFGLD GSVPPDLDWK
550 560 570
GQPTAPPKKG LLQRLFSRQD CCGNCSDSEE ELPTRL