| actin cytoskeleton reorganization |
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins. |
| angiogenesis |
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| angiogenesis involved in coronary vascular morphogenesis |
Blood vessel formation in the heart when new vessels emerge from the proliferation of pre-existing blood vessels. |
| artery morphogenesis |
The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs. |
| axon extension |
Long distance growth of a single axon process involved in cellular development. |
| axon extension involved in axon guidance |
The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues. |
| axon guidance |
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. |
| axonal fasciculation |
The collection of axons into a bundle of rods, known as a fascicle. |
| axonogenesis involved in innervation |
The neurite development process that generates a long process of a neuron, as it invades a target tissue. |
| basal dendrite arborization |
The process in which the anatomical structures of a dendritic tree are generated on the basal neuron side and organized into dendritic branches. |
| basal dendrite development |
The process whose specific outcome is the progression of a basal dendrite over time, from its formation to the mature structure. |
| blood vessel endothelial cell migration |
The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis. |
| branching involved in blood vessel morphogenesis |
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system. |
| branchiomotor neuron axon guidance |
The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx. |
| cell migration involved in coronary vasculogenesis |
The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form the blood vessels of the heart. |
| cell migration involved in sprouting angiogenesis |
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis. |
| cellular response to hepatocyte growth factor stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus. |
| cellular response to vascular endothelial growth factor stimulus |
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus. |
| commissural neuron axon guidance |
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues. |
| coronary artery morphogenesis |
The process in which the anatomical structures of coronary arteries are generated and organized. Coronary arteries are blood vessels that transport blood to the heart muscle. |
| dendrite development |
The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. |
| dichotomous subdivision of terminal units involved in salivary gland branching |
The process in which a salivary epithelial cord bifurcates at its end. |
| dorsal root ganglion morphogenesis |
The developmental process by which a dorsal root ganglion is generated and organized. |
| endothelial cell chemotaxis |
The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). |
| endothelial cell migration |
The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. |
| facial nerve structural organization |
The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities. |
| facioacoustic ganglion development |
The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure. |
| gonadotrophin-releasing hormone neuronal migration to the hypothalamus |
The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus. |
| heart development |
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. |
| hepatocyte growth factor receptor signaling pathway |
The series of molecular signals initiated by a ligand binding to a hepatocyte growth factor receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| integrin-mediated signaling pathway |
The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| motor neuron axon guidance |
The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| motor neuron migration |
The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement. |
| negative regulation of axon extension |
Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth. |
| negative regulation of axon extension involved in axon guidance |
Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance. |
| negative regulation of extrinsic apoptotic signaling pathway |
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway. |
| negative regulation of neuron apoptotic process |
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons. |
| nerve development |
The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure. |
| neural crest cell migration |
The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. |
| neural crest cell migration involved in autonomic nervous system development |
Any neural crest cell migration that is involved in autonomic nervous system development. |
| neuron development |
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. |
| neuron migration |
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. |
| neuropilin signaling pathway |
The series of molecular signals initiated by an extracellular ligand binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| otic placode development |
The process whose specific outcome is the progression of an otic placode over time, from its formation to the mature structure. |
| outflow tract septum morphogenesis |
The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract. |
| platelet-derived growth factor receptor signaling pathway |
The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| positive chemotaxis |
The directed movement of a motile cell or organism towards a higher concentration of a chemical. |
| positive regulation of actin cytoskeleton reorganization |
Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization. |
| positive regulation of angiogenesis |
Any process that activates or increases angiogenesis. |
| positive regulation of axon extension involved in axon guidance |
Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance. |
| positive regulation of cell migration involved in sprouting angiogenesis |
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. |
| positive regulation of endothelial cell migration |
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium. |
| positive regulation of ERK1 and ERK2 cascade |
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade. |
| positive regulation of filopodium assembly |
Any process that activates or increases the frequency, rate or extent of the assembly of a filopodium, a thin, stiff protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal growth cone. |
| positive regulation of focal adhesion assembly |
Any process that activates or increases the frequency, rate or extent of focal adhesion assembly, the establishment and maturation of focal adhesions. |
| positive regulation of peptidyl-tyrosine phosphorylation |
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine. |
| positive regulation of phosphorylation |
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule. |
| positive regulation of retinal ganglion cell axon guidance |
Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance. |
| positive regulation of stress fiber assembly |
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. |
| positive regulation of substrate adhesion-dependent cell spreading |
Any process that activates or increases the frequency, rate or extent of substrate adhesion-dependent cell spreading. |
| postsynapse organization |
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. |
| protein localization to early endosome |
A process in which a protein is transported to, or maintained in, a location within an early endosome. |
| regulation of axon extension involved in axon guidance |
Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance. |
| regulation of Cdc42 protein signal transduction |
Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction. |
| regulation of retinal ganglion cell axon guidance |
Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. |
| regulation of vascular endothelial growth factor receptor signaling pathway |
Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity. |
| renal artery morphogenesis |
The process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood. |
| response to wounding |
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism. |
| retina vasculature morphogenesis in camera-type eye |
The process in which the vasculature of the retina is generated and organized. |
| retinal ganglion cell axon guidance |
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues. |
| semaphorin-plexin signaling pathway |
The series of molecular signals generated as a consequence of a semaphorin receptor (composed of a plexin and a neurophilin) binding to a semaphorin ligand. |
| semaphorin-plexin signaling pathway involved in axon guidance |
Any semaphorin-plexin signaling pathway that is involved in axon guidance. |
| semaphorin-plexin signaling pathway involved in neuron projection guidance |
Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance. |
| sensory neuron axon guidance |
The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses. |
| sprouting angiogenesis |
The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation. |
| substrate adhesion-dependent cell spreading |
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate. |
| substrate-dependent cell migration, cell extension |
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell. |
| sympathetic ganglion development |
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure. |
| sympathetic nervous system development |
The process whose specific outcome is the progression of the sympathetic nervous system over time, from its formation to the mature structure. The sympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system (the other being the parasympathetic nervous system). The sympathetic preganglionic neurons have their cell bodies in the thoracic and lumbar regions of the spinal cord and connect to the paravertebral chain of sympathetic ganglia. Innervate heart and blood vessels, sweat glands, viscera and the adrenal medulla. Most sympathetic neurons, but not all, use noradrenaline as a post-ganglionic neurotransmitter. |
| sympathetic neuron projection extension |
Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite. |
| sympathetic neuron projection guidance |
The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues. |
| toxin transport |
The directed movement of a toxin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| trigeminal ganglion development |
The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure. |
| trigeminal nerve morphogenesis |
The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. |
| trigeminal nerve structural organization |
The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae. |
| vascular endothelial growth factor receptor signaling pathway |
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vasculogenesis |
The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes. |
| VEGF-activated neuropilin signaling pathway |
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| VEGF-activated neuropilin signaling pathway involved in axon guidance |
Any VEGF-activated neuropilin signaling pathway that is involved in axon guidance. |
| ventral trunk neural crest cell migration |
The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta. |
| vestibulocochlear nerve structural organization |
The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea. |
| viral entry into host cell |
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. |
