O35375

PR
Gene name
Nrp2
Protein name
Neuropilin-2
Names
Vascular endothelial cell growth factor 165 receptor 2
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18187
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

266-345 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O35375

Entry ID Method Resolution Chain Position Source
AF-O35375-F1 Predicted AlphaFoldDB

40 variants for O35375

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388474428 11 L>I No EVA
rs3388472670 44 G>S No EVA
rs3388472104 52 H>D No EVA
rs3388474219 71 N>K No EVA
rs3390072731 91 R>H No EVA
rs3388473807 92 D>V No EVA
rs3388472500 182 K>E No EVA
rs3390053689 186 E>V No EVA
rs3388474202 234 T>K No EVA
rs3388474796 235 P>S No EVA
rs3388474574 236 S>T No EVA
rs3388473896 237 K>T No EVA
rs3388472465 242 T>K No EVA
rs3388474245 288 I>V No EVA
rs3388473317 299 F>L No EVA
rs3388473683 303 R>G No EVA
rs3388474250 305 T>S No EVA
rs3388473892 323 D>E No EVA
rs3388474825 337 T>A No EVA
rs3388474087 350 R>S No EVA
rs3388473637 370 E>A No EVA
rs3388474494 373 M>K No EVA
rs3388473976 510 D>N No EVA
rs3388473728 569 Q>R No EVA
rs3388474672 573 V>M No EVA
rs3388472505 593 D>Y No EVA
rs242143292 608 V>M No EVA
rs3388473755 618 P>S No EVA
rs3388474697 621 E>D No EVA
rs3388473740 626 C>S No EVA
rs3388472137 706 P>Q No EVA
rs3388474439 709 L>P No EVA
rs3388474782 743 L>P No EVA
rs3388476069 745 V>G No EVA
rs3388474735 750 Q>K No EVA
rs3388474752 762 P>S No EVA
rs3388473287 784 I>N No EVA
rs3388473308 825 Y>F No EVA
rs3390008061 827 D>G No EVA
rs3388473752 855 E>K No EVA

No associated diseases with O35375

6 regional properties for O35375

Type Name Position InterPro Accession
domain Coagulation factor 5/8 C-terminal domain 276 - 427 IPR000421-1
domain Coagulation factor 5/8 C-terminal domain 433 - 592 IPR000421-2
domain CUB domain 28 - 142 IPR000859-1
domain CUB domain 149 - 267 IPR000859-2
domain MAM domain 641 - 802 IPR000998
domain Neuropilin, C-terminal 853 - 931 IPR022579

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
glutamatergic synapse A synapse that uses glutamate as a neurotransmitter.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
integral component of postsynaptic membrane The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

6 GO annotations of molecular function

Name Definition
heparin binding Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
identical protein binding Binding to an identical protein or proteins.
metal ion binding Binding to a metal ion.
semaphorin receptor activity Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
vascular endothelial growth factor receptor activity Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.

24 GO annotations of biological process

Name Definition
angiogenesis Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
axon extension involved in axon guidance The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues.
axon guidance The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
cellular response to leukemia inhibitory factor Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
dorsal root ganglion morphogenesis The developmental process by which a dorsal root ganglion is generated and organized.
facial nerve structural organization The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities.
facioacoustic ganglion development The process whose specific outcome is the progression of an acoustico-facial VII-VIII ganglion complex over time, from its formation to the mature structure.
gonadotrophin-releasing hormone neuronal migration to the hypothalamus The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus.
heart development The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
negative chemotaxis The directed movement of a motile cell or organism towards a lower concentration of a chemical.
nerve development The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.
neural crest cell migration involved in autonomic nervous system development Any neural crest cell migration that is involved in autonomic nervous system development.
neuron migration The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
outflow tract septum morphogenesis The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract.
regulation of postsynapse organization Any process that modulates the physical form of a postsynapse.
semaphorin-plexin signaling pathway involved in neuron projection guidance Any semaphorin-plexin signaling pathway that is involved in neuron projection guidance.
sensory neuron axon guidance The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.
sympathetic ganglion development The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
sympathetic neuron projection extension Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
sympathetic neuron projection guidance The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.
trigeminal ganglion development The process whose specific outcome is the progression of a trigeminal ganglion over time, from its formation to the mature structure.
trunk neural crest cell migration The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo.
ventral trunk neural crest cell migration The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta.
vestibulocochlear nerve structural organization The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea.

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O60462 NRP2 Neuropilin-2 Homo sapiens (Human) PR
P97333 Nrp1 Neuropilin-1 Mus musculus (Mouse) PR
Q91ZV3 Dcbld2 Discoidin, CUB and LCCL domain-containing protein 2 Mus musculus (Mouse) PR
O35276 Nrp2 Neuropilin-2 Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDMFPLTWVF LALYFSGHEV RSQQDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY
70 80 90 100 110 120
APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSVL
130 140 150 160 170 180
YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL
190 200 210 220 230 240
AKPRMEIILQ FLTFDLEHDP LQVGEGDCKY DWLDIWDGIP HVGPLIGKYC GTKTPSKLRS
250 260 270 280 290 300
STGILSLTFH TDMAVAKDGF SARYYLIHQE PPENFQCNVP LGMESGRIAN EQISASSTFS
310 320 330 340 350 360
DGRWTPQQSR LHGDDNGWTP NLDSNKEYLQ VDLRFLTMLT AIATQGAISR ETQKGYYVKS
370 380 390 400 410 420
YKLEVSTNGE DWMVYRHGKN HKIFQANNDA TEVVLNKLHM PLLTRFIRIR PQTWHLGIAL
430 440 450 460 470 480
RLELFGCRVT DAPCSNMLGM LSGLIADTQI SASSTREYLW SPSAARLVSS RSGWFPRNPQ
490 500 510 520 530 540
AQPGEEWLQV DLGTPKTVKG VIIQGARGGD SITAVEARAF VRKFKVSYSL NGKDWEYIQD
550 560 570 580 590 600
PRTQQTKLFE GNMHYDTPDI RRFDPVPAQY VRVYPERWSP AGIGMRLEVL GCDWTDSKPT
610 620 630 640 650 660
VETLGPTVKS EETTTPYPMD EDATECGENC SFEDDKDLQL PSGFNCNFDF PEETCGWVYD
670 680 690 700 710 720
HAKWLRSTWI SSANPNDRTF PDDKNFLKLQ SDGRREGQYG RLISPPVHLP RSPVCMEFQY
730 740 750 760 770 780
QAMGGHGVAL QVVREASQES KLLWVIREDQ GSEWKHGRII LPSYDMEYQI VFEGVIGKGR
790 800 810 820 830 840
SGEISIDDIR ISTDVPLENC MEPISAFAGE DFKVDIPETH GGEGYEDEID DEYEGDWSNS
850 860 870 880 890 900
SSSTSGAGDP SSGKEKSWLY TLDPILITII AMSSLGVLLG ATCAGLLLYC TCSYSGLSSR
910 920 930
SCTTLENYNF ELYDGLKHKV KINHQKCCSE A