Q91ZV3

PR
Gene name
Dcbld2 (Esdn)
Protein name
Discoidin, CUB and LCCL domain-containing protein 2
Names
Endothelial and smooth muscle cell-derived neuropilin-like protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:73379
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

433-510 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q91ZV3

Entry ID Method Resolution Chain Position Source
AF-Q91ZV3-F1 Predicted AlphaFoldDB

31 variants for Q91ZV3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs260599770 19 P>R No EVA
rs581145559 22 P>S No EVA
rs3389424214 70 G>R No EVA
rs3389415642 100 I>S No EVA
rs3389437923 108 I>N No EVA
rs3412992205 133 G>V No EVA
rs3389419564 248 G>V No EVA
rs3389411038 334 G>R No EVA
rs3405313475 348 L>Q No EVA
rs3389415678 370 E>K No EVA
rs3389421703 418 L>M No EVA
rs3389371333 434 Q>H No EVA
rs3389421736 456 K>N No EVA
rs3389410966 457 L>F No EVA
rs3389418657 457 L>P No EVA
rs3389419566 458 T>S No EVA
rs51055212 464 G>S No EVA
rs49907687 468 R>K No EVA
rs259617769 498 V>L No EVA
rs3389380936 500 P>L No EVA
rs3389437965 527 V>I No EVA
rs47892328 602 A>P No EVA
rs3389389429 624 I>F No EVA
rs3389424198 624 I>N No EVA
rs3389401817 628 L>F No EVA
rs221550769 654 M>I No EVA
rs260785336 654 M>V No EVA
rs3410819153 672 Y>N No EVA
rs48566558 677 V>I No EVA
rs250050481 704 H>P No EVA
rs1132860481 725 A>T No EVA

No associated diseases with Q91ZV3

3 regional properties for Q91ZV3

Type Name Position InterPro Accession
domain Coagulation factor 5/8 C-terminal domain 288 - 446 IPR000421
domain CUB domain 69 - 184 IPR000859
domain LCCL domain 188 - 282 IPR004043

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
signaling receptor activity Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.

2 GO annotations of biological process

Name Definition
negative regulation of cell growth Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
wound healing The series of events that restore integrity to a damaged tissue, following an injury.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96PD2 DCBLD2 Discoidin, CUB and LCCL domain-containing protein 2 Homo sapiens (Human) PR
P97333 Nrp1 Neuropilin-1 Mus musculus (Mouse) PR
O35375 Nrp2 Neuropilin-2 Mus musculus (Mouse) PR
10 20 30 40 50 60
MASRAPLRAA RSPQGPGGPA APAATGRAAL PSAGCCPLPP GRNSSSRPRL LLLLLLLLQD
70 80 90 100 110 120
AGGQQGDGCG HTVLGPESGT LTSINYPHTY PNSTVCEWEI RVRTGERIRI KFGDFDIEDS
130 140 150 160 170 180
DYCHLNYLKI FNGIGVSRTE IGKYCGLGLQ MNQSIESKGS EVTVLFMSGT HAAGRGFLAS
190 200 210 220 230 240
YSVIDKEDLI TCLDTVSNFL EPEFSKYCPA GCLLPFAEIS GTIPHGYRDS SPLCMAGIHA
250 260 270 280 290 300
GVVSNVLGGQ ISIVISKGTP YYESSLANNV TSTVGYLSAS LFTFKTSGCY GTLGMESGVI
310 320 330 340 350 360
ADPQITASSA LEWTDHMGQE NSWTAEKARL RKPGPPWAAF ATDEHQWLQI DLNKEKKITG
370 380 390 400 410 420
IVTTGSTMIE HSYYVSAYRV LYSDDGQRWT VYREPGVDQD KIFQGNKDYH KDVRNNFLPP
430 440 450 460 470 480
IIARFIRVNP VQWQQKIAMK VELLGCQFTL KGRLPKLTPP PRNGNNLRNT TARPKLGKGR
490 500 510 520 530 540
APKFTQVLQP RSRNELPVQP AETTTTPDIK NTTVTPSVTK DVALAAVLVP VLVMALTTLI
550 560 570 580 590 600
LILVCAWHWR NRKKKTEGAY DLPHWDRAGW WKGMKQLLPA KSVDHEETPV RYSTSEVSHL
610 620 630 640 650 660
SAREVTTVLQ ADSAEYAQPL VGGIVGTLHQ RSTFKPEEGK EAGYADLDPY NSPMQEVYHA
670 680 690 700 710 720
YAEPLPVTGP EYATPIVMDM SGHPTASVGL PSTSTFKTAG TQPHALVGTY NTLLSRTDSC
730 740 750 760
SSGQAQYDTP KGGKSAATPE ELVYQVPQST QELSGAGRDE KFDAFKEIL