AiPD: Autoinhibited Protein Database

Gene name	Tuba4a (Tuba4)
Protein name	Tubulin alpha-4A chain
Names	Alpha-tubulin 4, Alpha-tubulin isotype M-alpha-4, Tubulin alpha-4 chain
Species	Mus musculus (Mouse)
KEGG Pathway	mmu:22145
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

394-448 (Predicted disordered autoinhibitory region) PR

394-448 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
8IXF	EM	440 A	A/B/C/D/E/F/G/H/I	1-448	PDB
8IXG	EM	440 A	B/H/J/K	1-448	PDB
AF-P68368-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
rs3388481726	15	Q>*	No	EVA
rs3388480295	35	Q>R	No	EVA
rs3388480813	50	T>A	No	EVA
rs3388479294	58	A>V	No	EVA
rs3390192836	77	E>D	No	EVA
rs3390192915	77	E>Q	No	EVA
rs3390201965	77	E>V	No	EVA
rs3390180961	79	R>*	No	EVA
rs3388479621	110	I>T	No	EVA
rs3388479521	119	L>V	No	EVA
rs3388479549	125	L>V	No	EVA
rs3388480512	130	T>I	No	EVA
rs3388478807	216	N>S	No	EVA
rs3388479353	220	E>D	No	EVA
rs3388479324	254	E>D	No	EVA
rs3388480397	254	E>G	No	EVA
rs3388480429	255	F>V	No	EVA
rs3388478790	259	L>Q	No	EVA
rs3388480478	260	V>G	No	EVA
rs3388479403	268	P>L	No	EVA
rs3388480262	270	A>T	No	EVA
rs3388481614	294	A>T	No	EVA
rs3390118185	303	V>E	No	EVA
rs3390047506	307	P>H	No	EVA
rs3390188887	308	R>L	No	EVA
rs3390183554	309	H>D	No	EVA
rs3390192924	309	H>L	No	EVA
rs3390211063	310	G>A	No	EVA
rs3390181012	311	K>M	No	EVA
rs3390144932	311	K>Q	No	EVA
rs3390162039	313	M>L	No	EVA
rs3388479255	319	Y>*	No	EVA
rs3388479547	320	R>C	No	EVA
rs3388481668	325	P>S	No	EVA
rs3388479574	347	C>R	No	EVA
rs3388479395	357	Y>H	No	EVA
rs3388480435	365	G>W	No	EVA
rs3390203163	370	K>E	No	EVA
rs3388479722	373	R>H	No	EVA
rs3388478779	392	D>V	No	EVA
rs3388479800	394	K>M	No	EVA
rs3388479633	434	E>K	No	EVA

Type	Name	Position	InterPro Accession
domain	Tubulin/FtsZ, GTPase domain	3 - 246	IPR003008
conserved_site	Tubulin, conserved site	142 - 148	IPR017975
domain	Tubulin/FtsZ, 2-layer sandwich domain	248 - 393	IPR018316

		Description
EC Number
Subcellular Localization	Cytoplasm, cytoskeleton
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoskeleton	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
microtubule	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
microtubule cytoskeleton	The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.

Name	Definition
enzyme binding	Binding to an enzyme, a protein with catalytic activity.
GTP binding	Binding to GTP, guanosine triphosphate.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
structural constituent of cytoskeleton	The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.

Name	Definition
microtubule cytoskeleton organization	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
Q9ZRB7	TUBA	Tubulin alpha chain	Triticum aestivum (Wheat)	PR
P09734	TUB3	Tubulin alpha-3 chain	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	PR
Q6VAG1		Tubulin alpha-1 chain	Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)	PR
Q6VAF9		Tubulin alpha-4 chain	Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)	PR
Q6VAG0		Tubulin alpha-2 chain	Gossypium hirsutum (Upland cotton) (Gossypium mexicanum)	PR
P68366	TUBA4A	Tubulin alpha-4A chain	Homo sapiens (Human)	PR
P14640	TUBA1	Tubulin alpha-1 chain	Zea mays (Maize)	PR
P22275	TUBA3	Tubulin alpha-3 chain	Zea mays (Maize)	PR
P33627	TUBA6	Tubulin alpha-6 chain	Zea mays (Maize)	PR
Q02245	TUBA5	Tubulin alpha-5 chain	Zea mays (Maize)	PR
P14641	TUBA2	Tubulin alpha-2 chain	Zea mays (Maize)	PR
P28752	TUBA1	Tubulin alpha-1 chain	Oryza sativa subsp japonica (Rice)	PR
Q53M52	TUBA	Tubulin alpha-2 chain	Oryza sativa subsp japonica (Rice)	PR
B9DGT7	TUBA2	Tubulin alpha-2 chain	Arabidopsis thaliana (Mouse-ear cress)	PR
Q0WV25	TUBA4	Tubulin alpha-4 chain	Arabidopsis thaliana (Mouse-ear cress)	PR
P29511	TUBA6	Tubulin alpha-6 chain	Arabidopsis thaliana (Mouse-ear cress)	PR