P29511
PR
Gene name |
TUBA6 (TUA6, At4g14960, dl3520c) |
Protein name |
Tubulin alpha-6 chain |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT4G14960 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P29511
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P29511-F1 | Predicted | AlphaFoldDB |
1 variants for P29511
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH14196826 | 177 | V>M | No | 1000Genomes |
No associated diseases with P29511
9 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| nucleolus | A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. |
| plant-type cell wall | A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
| plasmodesma | A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell. |
| tubulin complex | A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly. |
| vacuole | A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular response to gravity | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9ZRB7 | TUBA | Tubulin alpha chain | Triticum aestivum (Wheat) | PR |
| P09734 | TUB3 | Tubulin alpha-3 chain | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | PR |
| Q6VAG1 | Tubulin alpha-1 chain | Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) | PR | |
| P68366 | TUBA4A | Tubulin alpha-4A chain | Homo sapiens (Human) | PR |
| P33627 | TUBA6 | Tubulin alpha-6 chain | Zea mays (Maize) | PR |
| Q02245 | TUBA5 | Tubulin alpha-5 chain | Zea mays (Maize) | PR |
| P14640 | TUBA1 | Tubulin alpha-1 chain | Zea mays (Maize) | PR |
| P22275 | TUBA3 | Tubulin alpha-3 chain | Zea mays (Maize) | PR |
| P14641 | TUBA2 | Tubulin alpha-2 chain | Zea mays (Maize) | PR |
| P68368 | Tuba4a | Tubulin alpha-4A chain | Mus musculus (Mouse) | PR |
| P28752 | TUBA1 | Tubulin alpha-1 chain | Oryza sativa subsp japonica (Rice) | PR |
| Q53M52 | TUBA | Tubulin alpha-2 chain | Oryza sativa subsp japonica (Rice) | PR |
| Q0WV25 | TUBA4 | Tubulin alpha-4 chain | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B9DGT7 | TUBA2 | Tubulin alpha-2 chain | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRECISIHIG | QAGIQVGNAC | WELYCLEHGI | QPDGQMPGDK | TVGGGDDAFN | TFFSETGAGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HVPRAVFVDL | EPTVIDEVRT | GTYRQLFHPE | QLISGKEDAA | NNFARGHYTI | GKEIVDLCLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RIRKLADNCT | GLQGFLVFNA | VGGGTGSGLG | SLLLERLSVD | YGKKSKLGFT | VYPSPQVSTS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVEPYNSVLS | THSLLEHTDV | SILLDNEAIY | DICRRSLNIE | RPTYTNLNRL | VSQVISSLTA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLRFDGALNV | DVTEFQTNLV | PYPRIHFMLS | SYAPVISAEK | AFHEQLSVAE | ITNSAFEPAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MMAKCDPRHG | KYMACCLMYR | GDVVPKDVNA | AVGTIKTKRT | IQFVDWCPTG | FKCGINYQPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVVPGGDLAK | VQRAVCMISN | STSVAEVFSR | IDHKFDLMYA | KRAFVHWYVG | EGMEEGEFSE |
| 430 | 440 | ||||
| AREDLAALEK | DYEEVGAEGG | DDEDDEGEEY |