P09734
PR
Gene name |
TUB3 (YML124C, YM7056.02C) |
Protein name |
Tubulin alpha-3 chain |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YML124C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P09734
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P09734-F1 | Predicted | AlphaFoldDB |
2 variants for P09734
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s13-23188 | 67 | I>V | No | SGRP | |
| s13-22774 | 205 | V>F | No | SGRP |
No associated diseases with P09734
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytoplasmic microtubule | Any microtubule in the cytoplasm of a cell. |
| kinetochore microtubule | Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| nuclear microtubule | Any microtubule in the nucleus of a cell. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spindle | The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. |
| tubulin complex | A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| homologous chromosome segregation | The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets. |
| microtubule cytoskeleton organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| mitotic sister chromatid segregation | The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets. |
| nuclear division | The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei. |
| nuclear migration along microtubule | The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins. |
| nuclear migration by microtubule mediated pushing forces | The directed movement of the nucleus by pushing forces exerted by polymerization of backward-extending microtubules. |
14 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9ZRB7 | TUBA | Tubulin alpha chain | Triticum aestivum (Wheat) | PR |
| Q6VAG1 | Tubulin alpha-1 chain | Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) | PR | |
| Q6VAF9 | Tubulin alpha-4 chain | Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) | PR | |
| Q6VAG0 | Tubulin alpha-2 chain | Gossypium hirsutum (Upland cotton) (Gossypium mexicanum) | PR | |
| P68366 | TUBA4A | Tubulin alpha-4A chain | Homo sapiens (Human) | PR |
| Q02245 | TUBA5 | Tubulin alpha-5 chain | Zea mays (Maize) | PR |
| P33627 | TUBA6 | Tubulin alpha-6 chain | Zea mays (Maize) | PR |
| P22275 | TUBA3 | Tubulin alpha-3 chain | Zea mays (Maize) | PR |
| P14640 | TUBA1 | Tubulin alpha-1 chain | Zea mays (Maize) | PR |
| P68368 | Tuba4a | Tubulin alpha-4A chain | Mus musculus (Mouse) | PR |
| P28752 | TUBA1 | Tubulin alpha-1 chain | Oryza sativa subsp japonica (Rice) | PR |
| Q53M52 | TUBA | Tubulin alpha-2 chain | Oryza sativa subsp japonica (Rice) | PR |
| P29511 | TUBA6 | Tubulin alpha-6 chain | Arabidopsis thaliana (Mouse-ear cress) | PR |
| B9DGT7 | TUBA2 | Tubulin alpha-2 chain | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MREVISINVG | QAGCQIGNAC | WELYSLEHGI | KEDGHLEDGL | SKPKGGEEGF | STFFHETGYG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KFVPRAIYVD | LEPNVIDEVR | TGRFKELFHP | EQLINGKEDA | ANNYARGHYT | VGREIVDEVE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ERIRKMADQC | DGLQGFLFTH | SLGGGTGSGL | GSLLLENLSY | EYGKKSKLEF | AVYPAPQLST |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SVVEPYNTVL | TTHTTLEHAD | CTFMVDNEAI | YDICKRNLGI | SRPSFSNLNG | LIAQVISSVT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ASLRFDGSLN | VDLNEFQTNL | VPYPRIHFPL | VSYAPILSKK | RATHESNSVS | EITNACFEPG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NQMVKCDPTK | GKYMANCLLY | RGDVVTRDVQ | RAVEQVKNKK | TVQMVDWCPT | GFKIGICYEP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PSVIPSSELA | NVDRAVCMLS | NTTAIADAWK | RIDQKFDLMY | AKRAFVHWYV | GEGMEEGEFT |
| 430 | 440 | ||||
| EAREDLAALE | RDYIEVGADS | YAEEF |