Q0WV25
Gene name |
TUBA4 (TUA4, At1g04820, F13M7.19) |
Protein name |
Tubulin alpha-4 chain |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT1G50010 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q0WV25
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q0WV25-F1 | Predicted | AlphaFoldDB |
1 variants for Q0WV25
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| tmp_1_18518883_A_T | 198 | T>S | No | 1000Genomes |
No associated diseases with Q0WV25
4 regional properties for Q0WV25
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | THIF-type NAD/FAD binding fold | 6 - 440 | IPR000594 |
| domain | Ubiquitin/SUMO-activating enzyme ubiquitin-like domain | 450 - 536 | IPR028077 |
| domain | SUMO-activating enzyme subunit 2, C-terminal domain | 547 - 636 | IPR032426 |
| active_site | Ubiquitin-activating enzyme E1, Cys active site | 171 - 179 | IPR033127 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| GTP binding | Binding to GTP, guanosine triphosphate. |
| structural constituent of cytoskeleton | The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| microtubule-based process | Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. |
12 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9ZRB7 | TUBA | Tubulin alpha chain | Triticum aestivum (Wheat) | PR |
| P68366 | TUBA4A | Tubulin alpha-4A chain | Homo sapiens (Human) | PR |
| P22275 | TUBA3 | Tubulin alpha-3 chain | Zea mays (Maize) | PR |
| P33627 | TUBA6 | Tubulin alpha-6 chain | Zea mays (Maize) | PR |
| Q02245 | TUBA5 | Tubulin alpha-5 chain | Zea mays (Maize) | PR |
| P14640 | TUBA1 | Tubulin alpha-1 chain | Zea mays (Maize) | PR |
| P14641 | TUBA2 | Tubulin alpha-2 chain | Zea mays (Maize) | PR |
| P68368 | Tuba4a | Tubulin alpha-4A chain | Mus musculus (Mouse) | PR |
| P28752 | TUBA1 | Tubulin alpha-1 chain | Oryza sativa subsp japonica (Rice) | PR |
| Q53M52 | TUBA | Tubulin alpha-2 chain | Oryza sativa subsp japonica (Rice) | PR |
| B9DGT7 | TUBA2 | Tubulin alpha-2 chain | Arabidopsis thaliana (Mouse-ear cress) | PR |
| P29511 | TUBA6 | Tubulin alpha-6 chain | Arabidopsis thaliana (Mouse-ear cress) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRECISIHIG | QAGIQVGNAC | WELYCLEHGI | QPDGQMPSDK | TVGGGDDAFN | TFFSETGAGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HVPRAVFVDL | EPTVIDEVRT | GTYRQLFHPE | QLISGKEDAA | NNFARGHYTI | GKEIVDLCLD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RIRKLADNCT | GLQGFLVFNA | VGGGTGSGLG | SLLLERLSVD | YGKKSKLGFT | VYPSPQVSTS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVEPYNSVLS | THSLLEHTDV | SILLDNEAIY | DICRRSLSIE | RPTYTNLNRL | VSQVISSLTA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SLRFDGALNV | DVTEFQTNLV | PYPRIHFMLS | SYAPVISAEK | AFHEQLSVAE | ITNSAFEPAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| MMAKCDPRHG | KYMACCLMYR | GDVVPKDVNA | AVGTIKTKRT | IQFVDWCPTG | FKCGINYQPP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TVVPGGDLAK | VQRAVCMISN | STSVAEVFSR | IDHKFDLMYA | KRAFVHWYVG | EGMEEGEFSE |
| 430 | 440 | ||||
| AREDLAALEK | DYEEVGAEGG | DDEDDEGEEY |