P55737

PR
Gene name
HSP90-2
Protein name
Heat shock protein 90-2
Names
AtHSP90.2, AtHsp90-2, Heat shock protein 81-2, Hsp81-2, Protein EARLY-RESPONSIVE TO DEHYDRATION 8, Protein LOSS OF RECOGNITION OF AVRRPM1 2, Protein MUTANT SNC1-ENHANCING 12
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G56030
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

488-699 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P55737

Entry ID Method Resolution Chain Position Source
AF-P55737-F1 Predicted AlphaFoldDB

14 variants for P55737

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH12796624 65 I>T No 1000Genomes
ENSVATH03437026 167 T>A No 1000Genomes
ENSVATH07430643 179 K>T No 1000Genomes
ENSVATH00736686 183 L>M No 1000Genomes
ENSVATH14634911 186 L>I No 1000Genomes
ENSVATH07430647 279 E>D No 1000Genomes
ENSVATH03437037 287 L>F No 1000Genomes
ENSVATH08577274 594 S>G No 1000Genomes
ENSVATH00736691 597 G>S No 1000Genomes
ENSVATH08577275 622 D>E No 1000Genomes
ENSVATH12796723 630 V>L No 1000Genomes
tmp_5_22689342_A_G 670 D>G No 1000Genomes
ENSVATH08577276 674 A>V No 1000Genomes
tmp_5_22689373_G_C 680 E>D No 1000Genomes

No associated diseases with P55737

3 regional properties for P55737

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 27 - 182 IPR003594
conserved_site Heat shock protein Hsp90, conserved site 25 - 34 IPR019805
domain Heat shock protein Hsp90, N-terminal 5 - 206 IPR020575

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
unfolded protein binding Binding to an unfolded protein.

6 GO annotations of biological process

Name Definition
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
chaperone-mediated protein folding The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P15108 HSC82 ATP-dependent molecular chaperone HSC82 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q0J4P2 HSP81-1 Heat shock protein 81-1 Oryza sativa subsp japonica (Rice) PR
P51818 HSP90-3 Heat shock protein 90-3 Arabidopsis thaliana (Mouse-ear cress) PR
O03986 HSP90-4 Heat shock protein 90-4 Arabidopsis thaliana (Mouse-ear cress) PR
P27323 HSP90-1 Heat shock protein 90-1 Arabidopsis thaliana (Mouse-ear cress) PR
P36181 HSC80 Heat shock cognate protein 80 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MADAETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES LTDKSKLDGQ
70 80 90 100 110 120
PELFIHIIPD KTNNTLTIID SGIGMTKADL VNNLGTIARS GTKEFMEALA AGADVSMIGQ
130 140 150 160 170 180
FGVGFYSAYL VADKVVVTTK HNDDEQYVWE SQAGGSFTVT RDTSGETLGR GTKMVLYLKE
190 200 210 220 230 240
DQLEYLEERR LKDLVKKHSE FISYPISLWI EKTIEKEISD DEEEEEKKDE EGKVEEVDEE
250 260 270 280 290 300
KEKEEKKKKK IKEVSHEWDL VNKQKPIWMR KPEEINKEEY AAFYKSLSND WEEHLAVKHF
310 320 330 340 350 360
SVEGQLEFKA ILFVPKRAPF DLFDTKKKPN NIKLYVRRVF IMDNCEDIIP EYLGFVKGIV
370 380 390 400 410 420
DSEDLPLNIS RETLQQNKIL KVIRKNLVKK CLELFFEIAE NKEDYNKFYE AFSKNLKLGI
430 440 450 460 470 480
HEDSQNRTKI AELLRYHSTK SGDELTSLKD YVTRMKEGQN DIFYITGESK KAVENSPFLE
490 500 510 520 530 540
KLKKKGIEVL YMVDAIDEYA IGQLKEFEGK KLVSATKEGL KLDETEDEKK KKEELKEKFE
550 560 570 580 590 600
GLCKVIKDVL GDKVEKVIVS DRVVDSPCCL VTGEYGWTAN MERIMKAQAL RDSSMAGYMS
610 620 630 640 650 660
SKKTMEINPE NSIMDELRKR ADADKNDKSV KDLVLLLFET ALLTSGFSLD EPNTFGSRIH
670 680 690
RMLKLGLSID DDDAVEADAE MPPLEDDADA EGSKMEEVD