P15108

PR
Gene name
HSC82 (YMR186W, YM8010.16)
Protein name
ATP-dependent molecular chaperone HSC82
Names
82 kDa heat shock cognate protein, Heat shock protein Hsp90 constitutive isoform
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YMR186W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

496-568 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P15108

Entry ID Method Resolution Chain Position Source
6XLB EM 380 A A/B 1-705 PDB
6XLC EM 366 A A/B 1-705 PDB
6XLD EM 366 A A/B 1-705 PDB
6XLE EM 274 A A/B 1-705 PDB
6XLF EM 315 A A/B 1-705 PDB
6XLG EM 271 A A/B 1-705 PDB
6XLH EM 283 A A/B 1-705 PDB
AF-P15108-F1 Predicted AlphaFoldDB

4 variants for P15108

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-632567 72 E>Q No SGRP
s13-632850 166 R>K No SGRP
s13-633993 547 T>I No SGRP
s13-634463 704 V>I No SGRP

No associated diseases with P15108

3 regional properties for P15108

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 26 - 180 IPR003594
conserved_site Heat shock protein Hsp90, conserved site 24 - 33 IPR019805
domain Heat shock protein Hsp90, N-terminal 4 - 205 IPR020575

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
unfolded protein binding Binding to an unfolded protein.

7 GO annotations of biological process

Name Definition
box C/D snoRNP assembly The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex.
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
proteasome assembly The aggregation, arrangement and bonding together of a mature, active proteasome complex.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
response to oxygen levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen.
telomere maintenance Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q0J4P2 HSP81-1 Heat shock protein 81-1 Oryza sativa subsp japonica (Rice) PR
P51818 HSP90-3 Heat shock protein 90-3 Arabidopsis thaliana (Mouse-ear cress) PR
O03986 HSP90-4 Heat shock protein 90-4 Arabidopsis thaliana (Mouse-ear cress) PR
P55737 HSP90-2 Heat shock protein 90-2 Arabidopsis thaliana (Mouse-ear cress) PR
P27323 HSP90-1 Heat shock protein 90-1 Arabidopsis thaliana (Mouse-ear cress) PR
P36181 HSC80 Heat shock cognate protein 80 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MAGETFEFQA EITQLMSLII NTVYSNKEIF LRELISNASD ALDKIRYQAL SDPKQLETEP
70 80 90 100 110 120
DLFIRITPKP EEKVLEIRDS GIGMTKAELI NNLGTIAKSG TKAFMEALSA GADVSMIGQF
130 140 150 160 170 180
GVGFYSLFLV ADRVQVISKN NEDEQYIWES NAGGSFTVTL DEVNERIGRG TVLRLFLKDD
190 200 210 220 230 240
QLEYLEEKRI KEVIKRHSEF VAYPIQLLVT KEVEKEVPIP EEEKKDEEKK DEDDKKPKLE
250 260 270 280 290 300
EVDEEEEEKK PKTKKVKEEV QELEELNKTK PLWTRNPSDI TQEEYNAFYK SISNDWEDPL
310 320 330 340 350 360
YVKHFSVEGQ LEFRAILFIP KRAPFDLFES KKKKNNIKLY VRRVFITDEA EDLIPEWLSF
370 380 390 400 410 420
VKGVVDSEDL PLNLSREMLQ QNKIMKVIRK NIVKKLIEAF NEIAEDSEQF DKFYSAFAKN
430 440 450 460 470 480
IKLGVHEDTQ NRAALAKLLR YNSTKSVDEL TSLTDYVTRM PEHQKNIYYI TGESLKAVEK
490 500 510 520 530 540
SPFLDALKAK NFEVLFLTDP IDEYAFTQLK EFEGKTLVDI TKDFELEETD EEKAEREKEI
550 560 570 580 590 600
KEYEPLTKAL KDILGDQVEK VVVSYKLLDA PAAIRTGQFG WSANMERIMK AQALRDSSMS
610 620 630 640 650 660
SYMSSKKTFE ISPKSPIIKE LKKRVDEGGA QDKTVKDLTN LLFETALLTS GFSLEEPTSF
670 680 690 700
ASRINRLISL GLNIDEDEET ETAPEASTEA PVEEVPADTE MEEVD