P27323

PR
Gene name
HSP90-1
Protein name
Heat shock protein 90-1
Names
AtHSP90.1, AtHsp90-1, Heat shock protein 81-1, Hsp81-1, Heat shock protein 83
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G52640
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

492-563 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P27323

Entry ID Method Resolution Chain Position Source
AF-P27323-F1 Predicted AlphaFoldDB

53 variants for P27323

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH14628358 2 A>V No 1000Genomes
ENSVATH07403032 32 L>V No 1000Genomes
ENSVATH12721181 55 S>R No 1000Genomes
tmp_5_21353049_C_T 60 Q>* No 1000Genomes
ENSVATH00729781 72 S>A Plants were checked bi-weekly for presence of first buds and the average flowering time of 4 plants of the same accession were collected [16c and 16 hrs daylight] [EnsemblGenome] No 1000Genomes
tmp_5_21353088_A_G 73 N>D No 1000Genomes
ENSVATH12721182 88 A>E No 1000Genomes
ENSVATH07403041 137 V>A No 1000Genomes
ENSVATH00729784 148 V>I No 1000Genomes
ENSVATH00729785 156 S>C No 1000Genomes
tmp_5_21353429_C_G 158 T>S No 1000Genomes
ENSVATH00729786 160 T>S No 1000Genomes
tmp_5_21353479_A_T
ENSVATH00729787
 175 T>S No 1000Genomes
ENSVATH12721225 186 L>W No 1000Genomes
tmp_5_21353608_G_T 188 E>D No 1000Genomes
tmp_5_21353615_C_G 191 L>V No 1000Genomes
tmp_5_21353669_T_C 209 W>R No 1000Genomes
ENSVATH07403049 210 T>I No 1000Genomes
tmp_5_21353677_G_T 211 E>D No 1000Genomes
tmp_5_21353681_A_C 213 T>P No 1000Genomes
ENSVATH07403051 228 K>N No 1000Genomes
ENSVATH07403050 228 K>T No 1000Genomes
ENSVATH07403052 229 K>R No 1000Genomes
tmp_5_21353854_G_C 270 L>F No 1000Genomes
ENSVATH07403054 283 A>G No 1000Genomes
ENSVATH07403055 299 K>I No 1000Genomes
tmp_5_21354057_G_A 338 R>K No 1000Genomes
ENSVATH00729791 389 V>L No 1000Genomes
ENSVATH14628361 399 I>L No 1000Genomes
tmp_5_21354240_T_C 399 I>T No 1000Genomes
tmp_5_21354259_C_G 405 D>E No 1000Genomes
ENSVATH07403060 423 E>D No 1000Genomes
tmp_5_21354358_C_G,T 438 H>Q No 1000Genomes
ENSVATH00729793 451 D>E No 1000Genomes
tmp_5_21354416_G_A 458 E>K No 1000Genomes
tmp_5_21354440_A_G 466 I>V No 1000Genomes
ENSVATH07403061 472 K>M No 1000Genomes
tmp_5_21354464_G_T 474 V>L No 1000Genomes
ENSVATH07403062 491 L>F No 1000Genomes
ENSVATH00729799 524 E>D No 1000Genomes
tmp_5_21354639_A_T 532 K>I No 1000Genomes
tmp_5_21354645_G_A 534 R>K No 1000Genomes
tmp_5_21354672_A_C 543 N>T No 1000Genomes
tmp_5_21354830_A_G 596 S>G No 1000Genomes
tmp_5_21354878_GACA_TACA,G 612 D>Y No 1000Genomes
tmp_5_21354925_G_T 627 K>N No 1000Genomes
tmp_5_21355000_T_A 652 D>E No 1000Genomes
ENSVATH12721234 675 E>K No 1000Genomes
ENSVATH07403072 676 N>K No 1000Genomes
ENSVATH03415535 677 V>I No 1000Genomes
ENSVATH07403073 683 M>V No 1000Genomes
tmp_5_21355095_C_T 684 P>L No 1000Genomes
ENSVATH03415536 695 K>R No 1000Genomes

No associated diseases with P27323

3 regional properties for P27323

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 27 - 182 IPR003594
conserved_site Heat shock protein Hsp90, conserved site 25 - 34 IPR019805
domain Heat shock protein Hsp90, N-terminal 5 - 206 IPR020575

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
unfolded protein binding Binding to an unfolded protein.

6 GO annotations of biological process

Name Definition
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
chaperone-mediated protein folding The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone.
defense response to bacterium Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P15108 HSC82 ATP-dependent molecular chaperone HSC82 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
O03986 HSP90-4 Heat shock protein 90-4 Arabidopsis thaliana (Mouse-ear cress) PR
P51818 HSP90-3 Heat shock protein 90-3 Arabidopsis thaliana (Mouse-ear cress) PR
P55737 HSP90-2 Heat shock protein 90-2 Arabidopsis thaliana (Mouse-ear cress) PR
P36181 HSC80 Heat shock cognate protein 80 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MADAETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES LTDKSKLDGQ
70 80 90 100 110 120
PELFIRLVPD KSNKTLSIID SGIGMTKADL VNNLGTIARS GTKEFMEALQ AGADVSMIGQ
130 140 150 160 170 180
FGVGFYSAYL VAEKVVVTTK HNDDEQYVWE SQAGGSFTVT RDVDGEPLGR GTKITLFLKD
190 200 210 220 230 240
DQLEYLEERR LKDLVKKHSE FISYPIYLWT EKTTEKEISD DEDEDEPKKE NEGEVEEVDE
250 260 270 280 290 300
EKEKDGKKKK KIKEVSHEWE LINKQKPIWL RKPEEITKEE YAAFYKSLTN DWEDHLAVKH
310 320 330 340 350 360
FSVEGQLEFK AILFVPKRAP FDLFDTRKKL NNIKLYVRRV FIMDNCEELI PEYLSFVKGV
370 380 390 400 410 420
VDSDDLPLNI SRETLQQNKI LKVIRKNLVK KCIEMFNEIA ENKEDYTKFY EAFSKNLKLG
430 440 450 460 470 480
IHEDSQNRGK IADLLRYHST KSGDEMTSFK DYVTRMKEGQ KDIFYITGES KKAVENSPFL
490 500 510 520 530 540
ERLKKRGYEV LYMVDAIDEY AVGQLKEYDG KKLVSATKEG LKLEDETEEE KKKREEKKKS
550 560 570 580 590 600
FENLCKTIKE ILGDKVEKVV VSDRIVDSPC CLVTGEYGWT ANMERIMKAQ ALRDSSMSGY
610 620 630 640 650 660
MSSKKTMEIN PDNGIMEELR KRAEADKNDK SVKDLVMLLY ETALLTSGFS LDEPNTFAAR
670 680 690
IHRMLKLGLS IDEDENVEED GDMPELEEDA AEESKMEEVD