P51818

PR
Gene name
HSP90-3
Protein name
Heat shock protein 90-3
Names
AtHSP90.3, AtHsp90-3, HSP81.2, Heat shock protein 81-3, Hsp81-3, Protein MUTANT SNC1-ENHANCING 10
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G56010
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

489-642 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P51818

Entry ID Method Resolution Chain Position Source
AF-P51818-F1 Predicted AlphaFoldDB

16 variants for P51818

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH12796325 61 P>S No 1000Genomes
tmp_5_22681909_A_G 66 H>R No 1000Genomes
ENSVATH07430474 72 T>S No 1000Genomes
tmp_5_22682358_A_T 183 M>L No 1000Genomes
tmp_5_22682367_A_C 186 I>L No 1000Genomes
tmp_5_22682520_G_A 237 V>I No 1000Genomes
tmp_5_22682574_T_A 255 S>T No 1000Genomes
ENSVATH12796397 486 G>S No 1000Genomes
ENSVATH12796402 523 D>E No 1000Genomes
ENSVATH14634886 590 L>W No 1000Genomes
tmp_5_22683598_G_C 596 G>A No 1000Genomes
tmp_5_22683624_A_T 605 M>L No 1000Genomes
tmp_5_22683778_G_C 656 G>A No 1000Genomes
ENSVATH12796411 675 V>A No 1000Genomes
ENSVATH14634889 682 P>L No 1000Genomes
tmp_5_22683874_C_G 688 A>G No 1000Genomes

No associated diseases with P51818

3 regional properties for P51818

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 27 - 182 IPR003594
conserved_site Heat shock protein Hsp90, conserved site 25 - 34 IPR019805
domain Heat shock protein Hsp90, N-terminal 5 - 206 IPR020575

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
secretory vesicle A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
unfolded protein binding Binding to an unfolded protein.

7 GO annotations of biological process

Name Definition
cellular response to calcium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
chaperone-mediated protein complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
response to heat Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P15108 HSC82 ATP-dependent molecular chaperone HSC82 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q0J4P2 HSP81-1 Heat shock protein 81-1 Oryza sativa subsp japonica (Rice) PR
O03986 HSP90-4 Heat shock protein 90-4 Arabidopsis thaliana (Mouse-ear cress) PR
P27323 HSP90-1 Heat shock protein 90-1 Arabidopsis thaliana (Mouse-ear cress) PR
P55737 HSP90-2 Heat shock protein 90-2 Arabidopsis thaliana (Mouse-ear cress) PR
P36181 HSC80 Heat shock cognate protein 80 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MADAETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES LTDKSKLDGQ
70 80 90 100 110 120
PELFIHIIPD KTNNTLTIID SGIGMTKADL VNNLGTIARS GTKEFMEALA AGADVSMIGQ
130 140 150 160 170 180
FGVGFYSAYL VADKVVVTTK HNDDEQYVWE SQAGGSFTVT RDTSGEALGR GTKMVLYLKE
190 200 210 220 230 240
DQMEYIEERR LKDLVKKHSE FISYPISLWI EKTIEKEISD DEEEEEKKDE EGKVEEVDEE
250 260 270 280 290 300
KEKEEKKKKK IKEVSHEWDL VNKQKPIWMR KPEEINKEEY AAFYKSLSND WEEHLAVKHF
310 320 330 340 350 360
SVEGQLEFKA ILFVPKRAPF DLFDTKKKPN NIKLYVRRVF IMDNCEDIIP EYLGFVKGIV
370 380 390 400 410 420
DSEDLPLNIS RETLQQNKIL KVIRKNLVKK CLELFFEIAE NKEDYNKFYE AFSKNLKLGI
430 440 450 460 470 480
HEDSQNRTKI AELLRYHSTK SGDELTSLKD YVTRMKEGQN DIFYITGESK KAVENSPFLE
490 500 510 520 530 540
KLKKKGIEVL YMVDAIDEYA IGQLKEFEGK KLVSATKEGL KLDETEDEKK KKEELKEKFE
550 560 570 580 590 600
GLCKVIKDVL GDKVEKVIVS DRVVDSPCCL VTGEYGWTAN MERIMKAQAL RDSSMGGYMS
610 620 630 640 650 660
SKKTMEINPE NSIMDELRKR ADADKNDKSV KDLVLLLFET ALLTSGFSLD EPNTFGSRIH
670 680 690
RMLKLGLSID DDDVVEADAD MPPLEDDADA EGSKMEEVD