O03986

PR
Gene name
HSP90-4
Protein name
Heat shock protein 90-4
Names
AtHSP90.4, AtHsp90-4, Heat shock protein 81-4, Hsp81-4
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT5G56000
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

489-645 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for O03986

Entry ID Method Resolution Chain Position Source
6HPG X-ray 200 A a/b/c/d/e/f 692-699 PDB
6Q3Q X-ray 200 A a/b 692-699 PDB
AF-O03986-F1 Predicted AlphaFoldDB

32 variants for O03986

Variant ID(s) Position Change Description Diseaes Association Provenance
tmp_5_22679669_C_T 47 R>K No 1000Genomes
tmp_5_22679597_T_G 71 K>T No 1000Genomes
ENSVATH07430373 73 N>K No 1000Genomes
tmp_5_22679262_T_G 147 Y>S No 1000Genomes
ENSVATH07430360 148 V>L No 1000Genomes
ENSVATH07430359 165 G>R No 1000Genomes
ENSVATH07430359 165 G>S No 1000Genomes
ENSVATH03436844 174 M>I No 1000Genomes
ENSVATH12796072 175 I>V No 1000Genomes
ENSVATH08577213 237 I>V No 1000Genomes
tmp_5_22678975_T_A 243 K>* No 1000Genomes
ENSVATH08577211 255 T>S No 1000Genomes
ENSVATH07430357 276 N>Y No 1000Genomes
tmp_5_22678797_A_G 302 V>A No 1000Genomes
ENSVATH03436837 311 I>V No 1000Genomes
ENSVATH12796065 351 D>E No 1000Genomes
ENSVATH12796044 461 E>D No 1000Genomes
tmp_5_22678309_T_C 465 I>V No 1000Genomes
ENSVATH12796043 472 A>T No 1000Genomes
ENSVATH12796039 486 G>A No 1000Genomes
ENSVATH07430354 510 K>T No 1000Genomes
ENSVATH03436820 526 D>E No 1000Genomes
ENSVATH07430353 536 K>N No 1000Genomes
ENSVATH03436814 559 V>I No 1000Genomes
ENSVATH07430348 616 E>K No 1000Genomes
tmp_5_22677835_C_T 623 A>T No 1000Genomes
tmp_5_22677834_G_A 623 A>V No 1000Genomes
ENSVATH12796003 647 F>S No 1000Genomes
ENSVATH03436811 670 E>D No 1000Genomes
ENSVATH03436810 671 E>D No 1000Genomes
tmp_5_22677682_C_T 674 A>T No 1000Genomes
ENSVATH12796002 688 A>D No 1000Genomes

No associated diseases with O03986

3 regional properties for O03986

Type Name Position InterPro Accession
domain Histidine kinase/HSP90-like ATPase 27 - 182 IPR003594
conserved_site Heat shock protein Hsp90, conserved site 25 - 34 IPR019805
domain Heat shock protein Hsp90, N-terminal 5 - 206 IPR020575

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

10 GO annotations of cellular component

Name Definition
apoplast The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
perinuclear region of cytoplasm Cytoplasm situated near, or occurring around, the nucleus.
plant-type cell wall A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances.
plant-type vacuole A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
plastid Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid.
protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
ATP-dependent protein folding chaperone Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis.
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
unfolded protein binding Binding to an unfolded protein.

3 GO annotations of biological process

Name Definition
cellular response to heat Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P15108 HSC82 ATP-dependent molecular chaperone HSC82 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q0J4P2 HSP81-1 Heat shock protein 81-1 Oryza sativa subsp japonica (Rice) PR
P27323 HSP90-1 Heat shock protein 90-1 Arabidopsis thaliana (Mouse-ear cress) PR
P51818 HSP90-3 Heat shock protein 90-3 Arabidopsis thaliana (Mouse-ear cress) PR
P55737 HSP90-2 Heat shock protein 90-2 Arabidopsis thaliana (Mouse-ear cress) PR
P36181 HSC80 Heat shock cognate protein 80 Solanum lycopersicum (Tomato) (Lycopersicon esculentum) PR
10 20 30 40 50 60
MADAETFAFQ AEINQLLSLI INTFYSNKEI FLRELISNSS DALDKIRFES LTDKSKLDGQ
70 80 90 100 110 120
PELFIHIIPD KTNNTLTIID SGIGMTKADL VNNLGTIARS GTKEFMEALA AGADVSMIGQ
130 140 150 160 170 180
FGVGFYSAYL VADKVVVTTK HNDDEQYVWE SQAGGSFTVT RDTSGEALGR GTKMILYLKE
190 200 210 220 230 240
DQMEYIEERR LKDLVKKHSE FISYPISLWI EKTIEKEISD DEEEEEKKDE EGKVEEIDEE
250 260 270 280 290 300
KEKEEKKKKK IKEVTHEWDL VNKQKPIWMR KPEEINKEEY AAFYKSLSND WEEHLAVKHF
310 320 330 340 350 360
SVEGQLEFKA ILFVPKRAPF DLFDTKKKPN NIKLYVRRVF IMDNCEDIIP DYLGFVKGIV
370 380 390 400 410 420
DSEDLPLNIS RETLQQNKIL KVIRKNLVKK CLELFFEIAE NKEDYNKFYE AFSKNLKLGI
430 440 450 460 470 480
HEDSQNRTKI AELLRYHSTK SGDELTSLKD YVTRMKEGQN EIFYITGESK KAVENSPFLE
490 500 510 520 530 540
KLKKKGYEVL YMVDAIDEYA IGQLKEFEGK KLVSATKEGL KLEETDDEKK KKEELKEKFE
550 560 570 580 590 600
GLCKVIKDVL GDKVEKVIVS DRVVDSPCCL VTGEYGWTAN MERIMKAQAL KDSNTGGYMS
610 620 630 640 650 660
SKKTMEINPE NSIMDELRKR AEADKNDKSV KDLVLLLFET ALLTSGFSLD EPNTFGSRIH
670 680 690
RMLKLGLSIE EDDAVEADAE MPPLEDDADA EGSKMEEVD