P49077

PR
Gene name
PYRB (At3g20330, MQC12.7)
Protein name
Aspartate carbamoyltransferase, chloroplastic
Names
Aspartate transcarbamylase, ATCase
Species
Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway
ath:AT3G20330
EC number
2.1.3.2: Carboxy- and carbamoyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

28-101 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P49077

Entry ID Method Resolution Chain Position Source
6YPO X-ray 167 A A/B 82-390 PDB
6YS6 X-ray 155 A A/B/C 82-390 PDB
6YSP X-ray 138 A A/B/C 82-390 PDB
6YVB X-ray 183 A A/B/C/D/E/F 82-390 PDB
6YW9 X-ray 168 A A/B/C 82-390 PDB
6YWJ X-ray 240 A A/B 82-390 PDB
6YY1 X-ray 306 A A/B/C/D/E/F 82-390 PDB
AF-P49077-F1 Predicted AlphaFoldDB

13 variants for P49077

Variant ID(s) Position Change Description Diseaes Association Provenance
ENSVATH05868801 5 S>L No 1000Genomes
ENSVATH05868800 14 G>S No 1000Genomes
ENSVATH05868799 18 F>V No 1000Genomes
ENSVATH10801413 33 P>H No 1000Genomes
ENSVATH10801413 33 P>L No 1000Genomes
ENSVATH10801412 35 P>H No 1000Genomes
ENSVATH00335846 107 E>K No 1000Genomes
tmp_3_7091200_T_C 207 N>S No 1000Genomes
tmp_3_7091014_A_G 236 I>T No 1000Genomes
ENSVATH13951973 245 A>G No 1000Genomes
tmp_3_7090705_C_T 300 A>T No 1000Genomes
ENSVATH00335844 330 Y>F No 1000Genomes
tmp_3_7090427_G_C 367 A>G No 1000Genomes

No associated diseases with P49077

2 regional properties for P49077

Type Name Position InterPro Accession
domain Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain 234 - 385 IPR006131
domain Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding 87 - 227 IPR006132

Functions

Description
EC Number 2.1.3.2 Carboxy- and carbamoyltransferases
Subcellular Localization
  • Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
chloroplast A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast stroma The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
aspartate carbamoyltransferase activity Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate.

5 GO annotations of biological process

Name Definition
'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
'de novo' UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.
cellular amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells.
cellular response to phosphate starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.
nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P11725 Otc Ornithine transcarbamylase, mitochondrial Mus musculus (Mouse) PR
P00481 Otc Ornithine transcarbamylase, mitochondrial Rattus norvegicus (Rat) PR
B9EXM2 CARB Carbamoyl-phosphate synthase large chain, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q6YV23 CARA Carbamoyl-phosphate synthase small chain, chloroplastic Oryza sativa subsp japonica (Rice) PR
Q9LVW7 CARA Carbamoyl-phosphate synthase small chain, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MSIASSLTSA TLCGASVFPK ALACSSEFPI NLPSPFESSK ICLTSFPASR DLKKNATLNL
70 80 90 100 110 120
TRNVGPVRCH AMQAGTRELK KFELSDVIEG KQFDREMLSA IFDVAREMEK IEKSSSQSEI
130 140 150 160 170 180
LKGYLMATLF YEPSTRTRLS FESAMKRLGG EVLTTENARE FSSAAKGETL EDTIRTVEGY
190 200 210 220 230 240
SDIIVMRHFE SGAARKAAAT ANIPVINAGD GPGEHPTQAL LDVYTIQSEI GKLDGISVAL
250 260 270 280 290 300
VGDLANGRTV RSLAYLLAKF KDVKIYFVSP EIVKMKDDIK DYLTSSGVEW EESSDLMEVA
310 320 330 340 350 360
SKCDVVYQTR IQRERFGERL DLYEAARGKY IVDKDLLGVM QKKAIIMHPL PRLDEITADV
370 380
DADPRAAYFR QAKNGLFIRM ALLKLLLVGW