AiPD: Autoinhibited Protein Database

Gene name	CARA (VEN6)
Protein name	Carbamoyl-phosphate synthase small chain, chloroplastic
Names	Carbamoyl-phosphate synthetase glutamine chain, Protein VENOSA 6
Species	Arabidopsis thaliana (Mouse-ear cress)
KEGG Pathway	ath:AT3G27740
EC number	6.3.5.5: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-77 (Predicted disordered autoinhibitory region) PR

1-77 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-Q9LVW7-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
tmp_3_10283743_G_A	17	S>F	No	1000Genomes
ENSVATH05939968	18	S>F	No	1000Genomes
ENSVATH11075391	26	G>S	No	1000Genomes
ENSVATH05939966	29	F>I	No	1000Genomes
ENSVATH05939966	29	F>L	No	1000Genomes
tmp_3_10283691_G_C	34	I>M	No	1000Genomes
tmp_3_10283659_G_A	45	T>I	No	1000Genomes
ENSVATH05939964	47	G>A	No	1000Genomes
tmp_3_10283441_C_T	59	R>K	No	1000Genomes
ENSVATH14036947	147	C>Y	No	1000Genomes
tmp_3_10282921_T_G	149	K>Q	No	1000Genomes
ENSVATH00356640	159	D>N	No	1000Genomes
ENSVATH00356637	228	A>P	No	1000Genomes
tmp_3_10282427_T_G	243	K>N	No	1000Genomes
ENSVATH00356634	265	Q>H	No	1000Genomes
tmp_3_10282244_G_T	270	P>Q	No	1000Genomes
ENSVATH11075313	277	E>K	No	1000Genomes
tmp_3_10282124_C_T	310	G>D	No	1000Genomes
ENSVATH05939947	330	G>A	No	1000Genomes
tmp_3_10282010_T_A	348	N>I	No	1000Genomes
tmp_3_10282007_T_A	349	N>I	No	1000Genomes
ENSVATH11075310	365	V>I	No	1000Genomes
tmp_3_10281760_G_A	370	L>F	No	1000Genomes
tmp_3_10281748_C_T	374	V>I	No	1000Genomes
ENSVATH02224101	393	E>A	No	1000Genomes
ENSVATH02224097	417	R>K	No	1000Genomes
tmp_3_10281475_A_C	430	S>A	No	1000Genomes

Type	Name	Position	InterPro Accession
No domain, repeats, and functional sites for Q9LVW7

		Description
EC Number	6.3.5.5	Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization	Plastid, chloroplast
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
carbamoyl-phosphate synthase complex	A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.
chloroplast	A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
chloroplast stroma	The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.

Name	Definition
'de novo' pyrimidine nucleobase biosynthetic process	The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
'de novo' UMP biosynthetic process	The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.
arginine biosynthetic process	The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
cellular response to phosphate starvation	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate.
glutamine metabolic process	The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
nitrogen compound metabolic process	The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
B9EXM2	CARB	Carbamoyl-phosphate synthase large chain, chloroplastic	Oryza sativa subsp japonica (Rice)	PR
Q6YV23	CARA	Carbamoyl-phosphate synthase small chain, chloroplastic	Oryza sativa subsp japonica (Rice)	PR
P49077	PYRB	Aspartate carbamoyltransferase, chloroplastic	Arabidopsis thaliana (Mouse-ear cress)	PR