P00481

PR
Gene name
Otc
Protein name
Ornithine transcarbamylase, mitochondrial
Names
OTCase, Ornithine carbamoyltransferase, mitochondrial
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25611
EC number
2.1.3.3: Carboxy- and carbamoyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-65 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P00481

Entry ID Method Resolution Chain Position Source
AF-P00481-F1 Predicted AlphaFoldDB

No variants for P00481

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P00481

No associated diseases with P00481

2 regional properties for P00481

Type Name Position InterPro Accession
domain Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain 187 - 340 IPR006131
domain Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding 40 - 181 IPR006132

Functions

Description
EC Number 2.1.3.3 Carboxy- and carbamoyltransferases
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

5 GO annotations of molecular function

Name Definition
amino acid binding Binding to an amino acid, organic acids containing one or more amino substituents.
identical protein binding Binding to an identical protein or proteins.
ornithine carbamoyltransferase activity Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline.
phosphate ion binding Binding to a phosphate ion.
phospholipid binding Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.

14 GO annotations of biological process

Name Definition
ammonium homeostasis Any biological process involved in the maintenance of an internal steady state of ammonium.
anion homeostasis Any process involved in the maintenance of an internal steady state of anions within an organism or cell.
arginine biosynthetic process via ornithine The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine.
citrulline biosynthetic process The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins.
liver development The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.
midgut development The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine.
ornithine catabolic process The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.
ornithine metabolic process The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.
response to biotin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotin stimulus.
response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
response to nutrient levels Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.
response to zinc ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus.
urea cycle The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P11725 Otc Ornithine transcarbamylase, mitochondrial Mus musculus (Mouse) PR
P49077 PYRB Aspartate carbamoyltransferase, chloroplastic Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MLSNLRILLN KAALRKAHTS MVRNFRYGKP VQSQVQLKGR DLLTLKNFTG EEIQYMLWLS
70 80 90 100 110 120
ADLKFRIKQK GEYLPLLQGK SLGMIFEKRS TRTRLSTETG FALLGGHPSF LTTQDIHLGV
130 140 150 160 170 180
NESLTDTARV LSSMTDAVLA RVYKQSDLDI LAKEATIPIV NGLSDLYHPI QILADYLTLQ
190 200 210 220 230 240
EHYGSLKGLT LSWIGDGNNI LHSIMMSAAK FGMHLQAATP KGYEPDPNIV KLAEQYAKEN
250 260 270 280 290 300
GTRLSMTNDP LEAARGGNVL ITDTWISMGQ EDEKKKRLQA FQGYQVTMKT AKVAASDWTF
310 320 330 340 350
LHCLPRKPEE VDDEVFYSPR SLVFPEAENR KWTIMAVMVS LLTDYSPVLQ KPKF