P30306
PR
Gene name |
Cdc25b (Cdc25m2) |
Protein name |
M-phase inducer phosphatase 2 |
Names |
Dual specificity phosphatase Cdc25B |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:12531 |
EC number |
3.1.3.48: Phosphoric monoester hydrolases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P30306
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P30306-F1 | Predicted | AlphaFoldDB |
21 variants for P30306
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs246888587 | 4 | P>H | No | EVA | |
| rs216276285 | 5 | L>P | No | EVA | |
| rs3392246762 | 40 | L>Q | No | EVA | |
| rs3412824780 | 72 | A>T | No | EVA | |
| rs3388591939 | 131 | Q>* | No | EVA | |
| rs3388595755 | 179 | G>D | No | EVA | |
| rs3388594800 | 204 | L>I | No | EVA | |
| rs3392084475 | 213 | L>W | No | EVA | |
| rs27243751 | 252 | Q>H | No | EVA | |
| rs3388592926 | 290 | L>I | No | EVA | |
| rs3388589619 | 305 | Q>H | No | EVA | |
| rs3388591966 | 351 | S>G | No | EVA | |
| rs3388587914 | 351 | S>R | No | EVA | |
| rs3388592929 | 366 | R>H | No | EVA | |
| rs3388591899 | 368 | F>Y | No | EVA | |
| rs3388589229 | 419 | L>M | No | EVA | |
| rs3388587928 | 475 | K>E | No | EVA | |
| rs3388589305 | 481 | F>Y | No | EVA | |
| rs27243739 | 489 | R>H | No | EVA | |
| rs3392246763 | 502 | R>H | No | EVA | |
| rs3388589613 | 568 | E>D | No | EVA |
No associated diseases with P30306
1 regional properties for P30306
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Rhodanese-like domain | 417 - 534 | IPR001763 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.1.3.48 | Phosphoric monoester hydrolases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| centrosome | A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein kinase binding | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. |
| protein tyrosine phosphatase activity | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. |
12 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| female meiosis I | The cell cycle process in which the first meiotic division occurs in the female germline. |
| G2/M transition of mitotic cell cycle | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| oocyte maturation | A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization. |
| positive regulation of cytokinesis | Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells. |
| positive regulation of G2/M transition of mitotic cell cycle | Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. |
| positive regulation of G2/MI transition of meiotic cell cycle | Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle. |
| positive regulation of mitotic cell cycle | Any process that activates or increases the rate or extent of progression through the mitotic cell cycle. |
| positive regulation of protein kinase activity | Any process that activates or increases the frequency, rate or extent of protein kinase activity. |
| protein dephosphorylation | The process of removing one or more phosphoric residues from a protein. |
| protein phosphorylation | The process of introducing a phosphate group on to a protein. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P20483 | stg | M-phase inducer phosphatase | Drosophila melanogaster (Fruit fly) | PR |
| P30304 | CDC25A | M-phase inducer phosphatase 1 | Homo sapiens (Human) | PR |
| P30305 | CDC25B | M-phase inducer phosphatase 2 | Homo sapiens (Human) | PR |
| Q336V5 | ACR2.1 | Arsenate reductase 2.1 | Oryza sativa subsp japonica (Rice) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEVPLQKSAP | GSALSPARVL | GGIQRPRHLS | VFEFESDGFL | GSPEPTASSS | PVTTLTQTMH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NLAGLGSEPP | KAQVGSLSFQ | NRLADLSLSR | RTSECSLSSE | SSESSDAGLC | MDSPSPVDPQ |
| 130 | 140 | 150 | 160 | 170 | 180 |
| MAERTFEQAI | QAASRVIQNE | QFTIKRFRSL | PVRLLEHSPV | LQSITNSRAL | DSWRKTEAGY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RAAANSPGED | KENDGYIFKM | PQELPHSSSA | QALAEWVSRR | QAFTQRPSSA | PDLMCLTTEW |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KMEVEELSPV | AQSSSLTPVE | RASEEDDGFV | DILESDLKDD | EKVPAGMENL | ISAPLVKKLD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KEEEQDLIMF | SKCQRLFRSP | SMPCSVIRPI | LKRLERPQDR | DVPVQSKRRK | SVTPLEEQQL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| EEPKARVFRS | KSLCHEIENI | LDSDHRGLIG | DYSKAFLLQT | VDGKHQDLKY | ISPETMVALL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TGKFSNIVEK | FVIVDCRYPY | EYEGGHIKNA | VNLPLERDAE | TFLLQRPIMP | CSLDKRIILI |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FHCEFSSERG | PRMCRFIRER | DRAANDYPSL | YYPEMYILKG | GYKEFFPQHP | NFCEPQDYRP |
| 550 | 560 | 570 | |||
| MNHEAFRDEL | RNFRLKTRSW | AGERSRRELC | SRLQDQ |