AiPD: Autoinhibited Protein Database

P30304

Gene name	CDC25A
Protein name	M-phase inducer phosphatase 1
Names	Dual specificity phosphatase Cdc25A
Species	Homo sapiens (Human)
KEGG Pathway	hsa:993
EC number	3.1.3.48: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

39-213 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

39-213 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

2 structures for P30304

Entry ID	Method	Resolution	Chain	Position	Source
1C25	X-ray	230 A	A	337-496	PDB
AF-P30304-F1	Predicted				AlphaFoldDB

309 variants for P30304

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA352997806 rs914324994	4	G>R		No	ClinGen TOPMed gnomAD
CA74106363 rs914324994	4	G>S		No	ClinGen TOPMed gnomAD
CA352997804 rs1378352193	4	G>V		No	ClinGen gnomAD
rs1434843977 CA352997796	5	P>L		No	ClinGen gnomAD
CA2372247 rs761234931	7	P>S		No	ClinGen ExAC TOPMed gnomAD
CA74106361 rs994319712	9	H>P		No	ClinGen TOPMed
rs994319712 CA352997773	9	H>R		No	ClinGen TOPMed
rs1158177901 CA352997766	10	R>H		No	ClinGen gnomAD
rs1408715616 CA352997756	12	R>G		No	ClinGen gnomAD
CA352997752 rs1178871220	12	R>L		No	ClinGen gnomAD
rs1199738200 CA352997746	14	L>V		No	ClinGen gnomAD
rs775789345 CA2372246	16	A>P		No	ClinGen ExAC TOPMed gnomAD
CA352997732 rs775789345	16	A>S		No	ClinGen ExAC TOPMed gnomAD
CA352997731 rs775789345	16	A>T		No	ClinGen ExAC TOPMed gnomAD
CA2372245 rs772493975	19	P>H		No	ClinGen ExAC TOPMed gnomAD
CA352997708 rs772493975	19	P>L		No	ClinGen ExAC TOPMed gnomAD
rs937463969 CA74106355	19	P>S		No	ClinGen Ensembl
rs1275767970 CA352997703	20	P>L		No	ClinGen gnomAD
rs1275767970 CA352997704	20	P>R		No	ClinGen gnomAD
CA2372244 rs746164227	20	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1425015047 CA352997697	21	P>L		No	ClinGen TOPMed
RCV000950103 rs146179438 CA2372241	24	Q>H		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA352997671 rs1472675189	26	V>I		No	ClinGen TOPMed
CA74106328 rs970012640	28	K>N		No	ClinGen TOPMed
rs972974061 CA74106324	29	A>V		No	ClinGen gnomAD
rs1465385924 CA352997644	30	L>P		No	ClinGen TOPMed
CA74106315 rs962870955	31	F>Y		No	ClinGen TOPMed gnomAD
CA352997625 rs1176948569	33	A>V		No	ClinGen gnomAD
rs1404341101 CA352997621	34	S>A		No	ClinGen TOPMed
rs1481276059 CA352997612	35	A>V		No	ClinGen gnomAD
rs1485915985 COSM1423700 CA352997601	37	G>V	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1017557847 CA16040295 COSM48276	37	G>W	lung [Cosmic]	No	ClinGen cosmic curated TOPMed gnomAD
rs754974662 CA352997594	39	L>M		No	ClinGen ExAC TOPMed gnomAD
rs754974662 CA352997593	39	L>V		No	ClinGen ExAC TOPMed gnomAD
CA352997561 rs1442401020	44	N>S		No	ClinGen gnomAD
CA74106283 rs867954944	47	V>F		No	ClinGen Ensembl
rs1277824616 CA352997536	48	T>I		No	ClinGen gnomAD
CA74106277 rs578041713	49	M>V		No	ClinGen TOPMed gnomAD
rs1308568476 CA352997518	51	Q>E		No	ClinGen gnomAD
rs1428867403 CA352997513	51	Q>H		No	ClinGen gnomAD
rs1479981301 CA352997501	53	Q>H		No	ClinGen TOPMed
rs746970478 CA2372237	53	Q>R		No	ClinGen ExAC gnomAD
CA352997497 rs1358542494	54	G>S		No	ClinGen gnomAD
TCGA novel	55	L>M	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs779797154 CA2372236	56	G>D		No	ClinGen ExAC gnomAD
rs1221030472 CA352997455	59	Y>D		No	ClinGen gnomAD
CA352997430 rs1293991664	62	P>S		No	ClinGen gnomAD
rs149296597 CA2372224	64	E>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs997089589 CA74105487	65	V>M		No	ClinGen Ensembl
CA352997400 rs1375182423	67	N>D		No	ClinGen gnomAD
rs1202488744 CA352997383	69	S>C		No	ClinGen TOPMed
rs1202488744 CA352997384	69	S>G		No	ClinGen TOPMed
rs1423565683 CA352997374	70	N>T		No	ClinGen gnomAD
rs1164990312 CA352997368	71	L>V		No	ClinGen gnomAD
rs1409184968 CA352997360	72	Q>R		No	ClinGen gnomAD
CA352997353 rs1380293119	73	R>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA352997348 rs1183145054	74	M>V		No	ClinGen gnomAD
rs746453844 CA2372220	75	G>S		No	ClinGen ExAC TOPMed gnomAD
rs780074569 CA2372219	76	S>F		No	ClinGen ExAC gnomAD
rs372589757 CA74105461	77	S>A		No	ClinGen Ensembl
CA16040297 rs1432423624	77	S>C		No	ClinGen TOPMed
CA352997325 rs1396873792	78	E>Q		No	ClinGen TOPMed
rs1271289307 CA352997308	80	T>I		No	ClinGen gnomAD
TCGA novel	81	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1414846913 CA352997293	82	S>L		No	ClinGen TOPMed gnomAD
CA74104104 rs759966798	83	G>D		No	ClinGen ExAC gnomAD
CA2372195 rs759966798	83	G>V		No	ClinGen ExAC gnomAD
CA2372193 rs749046270	87	D>E		No	ClinGen ExAC gnomAD
CA2372192 VAR_020932 rs3731499	88	S>F	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen UniProt ESP ExAC NCI-TCGA TOPMed dbSNP gnomAD
rs1216333941 CA352997240	89	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs939641591 CA74104054	89	P>S		No	ClinGen Ensembl
CA352997242 rs939641591	89	P>T		No	ClinGen Ensembl
rs1318350979 CA352997233	90	G>E		No	ClinGen TOPMed gnomAD
rs756265772 CA2372191	91	P>Q		No	ClinGen ExAC gnomAD
TCGA novel	91	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs781124013 CA2372189	93	D>G		No	ClinGen ExAC gnomAD
rs1168839398 CA352997211	94	S>G		No	ClinGen gnomAD
CA2372188 rs755018719	96	E>Q		No	ClinGen ExAC TOPMed gnomAD
rs747049751 CA2372165	99	E>G		No	ClinGen ExAC TOPMed gnomAD
rs199758768 CA74103582	100	N>K		No	ClinGen Ensembl
CA352997148 rs1353686764	101	P>A		No	ClinGen gnomAD
rs1290337332 CA352997142	102	M>V		No	ClinGen gnomAD
rs1186742351 CA16040296	105	I>T		No	ClinGen TOPMed
rs750847449 CA2372162	107	S>C		No	ClinGen ExAC gnomAD
rs148317132 CA2372163	107	S>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs765515421 CA2372161	109	P>T		No	ClinGen ExAC gnomAD
rs371158913 CA74103050	110	Q>R		No	ClinGen ESP TOPMed
rs747141888 CA2372148	115	C>Y		No	ClinGen ExAC gnomAD
rs1316172013 CA352997023	118	A>S		No	ClinGen gnomAD
rs758971374 CA2372146	118	A>V		No	ClinGen ExAC gnomAD
CA352997017 rs1379153510	119	L>P		No	ClinGen TOPMed
CA352996966 rs746366227	126	S>C		No	ClinGen ExAC gnomAD
CA2372145 rs746366227	126	S>F		No	ClinGen ExAC gnomAD
TCGA novel	127	L>P	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs963371313 CA74103017	127	L>R		No	ClinGen Ensembl
rs143367735 CA2372144	128	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA352996951 rs1400207543	129	H>Y		No	ClinGen TOPMed gnomAD
TCGA novel	130	D>G	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs149186214 CA2372142	131	I>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs923345015 CA74102974	132	F>C		No	ClinGen TOPMed gnomAD
CA74102970 rs770406262	133	Q>K		No	ClinGen Ensembl
rs1559964260 CA352996907	135	I>T		No	ClinGen Ensembl
rs142011702 CA2372139	136	D>N		No	ClinGen ESP ExAC gnomAD
rs1317881336 CA352996885	138	D>E		No	ClinGen TOPMed
rs765988410 CA2372138	138	D>H		No	ClinGen ExAC gnomAD
CA74102939 rs375655166	140	N>D		No	ClinGen ESP TOPMed gnomAD
CA352996876 rs375655166	140	N>H		No	ClinGen ESP TOPMed gnomAD
rs762490889 CA2372137	140	N>K		No	ClinGen ExAC gnomAD
CA2372120 rs757877366	144	E>D		No	ClinGen ExAC gnomAD
rs375690864 CA2372119	145	A>D		No	ClinGen ESP ExAC TOPMed gnomAD
CA2372118 rs375690864	145	A>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA352996809 rs1381790980	147	E>D		No	ClinGen gnomAD
rs761798691 CA2372117	148	F>L		No	ClinGen ExAC gnomAD
CA352996763 rs1367549377	154	P>R		No	ClinGen gnomAD
CA2372115 rs763881238	154	P>S		No	ClinGen ExAC gnomAD
CA352996761 rs1321477720	155	V>I		No	ClinGen gnomAD
CA2372114 rs760406123	157	R>C		No	ClinGen ExAC TOPMed gnomAD
CA2372113 rs372655408	157	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs372655408 CA2372112	157	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA74101647 rs770572616	158	G>V		No	ClinGen Ensembl
CA352996734 rs1182313958	159	C>W		No	ClinGen gnomAD
CA352996736 rs1308116667	159	C>Y		No	ClinGen TOPMed
rs774470623 CA352996730	160	L>P		No	ClinGen ExAC TOPMed gnomAD
rs774470623 CA2372110	160	L>R		No	ClinGen ExAC TOPMed gnomAD
CA2372109 rs771404791	161	H>R		No	ClinGen ExAC gnomAD
CA2372107 rs778364050	163	H>D		No	ClinGen ExAC TOPMed gnomAD
CA2372108 rs778364050	163	H>Y		No	ClinGen ExAC TOPMed gnomAD
CA2372106 rs749272262	164	G>R		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	167	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1250986434 CA352996679	168	G>D		No	ClinGen gnomAD
CA352996676 rs1460429462	169	K>E		No	ClinGen TOPMed
CA2372104 rs779890422	169	K>N		No	ClinGen ExAC gnomAD
rs748482211 CA2372105	169	K>R		No	ClinGen ExAC gnomAD
CA2372103 rs758047372	171	L>P		No	ClinGen ExAC TOPMed gnomAD
CA2372100 rs756655625	173	T>I		No	ClinGen ExAC TOPMed gnomAD
rs778482044 CA2372101	173	T>P		No	ClinGen ExAC gnomAD
CA2372098 rs753788423	174	Q>K		No	ClinGen ExAC
CA74101597 rs553480894	175	R>S		No	ClinGen TOPMed
rs1397621878 CA352996629	176	Q>R		No	ClinGen gnomAD
CA352996621 rs1370833186	177	N>S		No	ClinGen TOPMed gnomAD
rs760496535 CA352996611	179	A>S		No	ClinGen ExAC gnomAD
CA2372096 rs760496535	179	A>T		No	ClinGen ExAC gnomAD
CA2372095 rs752459968	179	A>V		No	ClinGen ExAC gnomAD
CA74101588 rs1046395415	180	P>S		No	ClinGen Ensembl
rs774367168 CA2372092	181	A>V		No	ClinGen ExAC gnomAD
rs6771386 CA74101577 VAR_023532	182	R>G		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA352996596 rs762890600	182	R>L		No	ClinGen ExAC TOPMed gnomAD
rs762890600 CA352996597	182	R>P		No	ClinGen ExAC TOPMed gnomAD
rs762890600 CA2372090	182	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs6771386 VAR_023533 CA2372091	182	R>W		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs773402032 CA2372071	184	L>P		No	ClinGen ExAC gnomAD
CA352996558 rs1235253089	186	S>L		No	ClinGen TOPMed
CA352996541 rs1286482102	189	R>G		No	ClinGen TOPMed
CA352996530 rs1379992426	190	D>G		No	ClinGen gnomAD
rs1289950255 CA352996513	192	S>N	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs975405163 CA74099806	194	P>S		No	ClinGen TOPMed gnomAD
rs1209816456 CA352996486	196	N>I		No	ClinGen TOPMed
rs371829889 CA2372065	202	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1230259689 CA352996440	203	P>H		No	ClinGen gnomAD
rs748848895 CA2372063	205	S>L		No	ClinGen ExAC gnomAD
CA2372061 rs756114919	206	P>S		No	ClinGen ExAC gnomAD
rs1260973619 CA352996419	207	V>M		No	ClinGen gnomAD
rs780939908 CA2372060	208	T>A		No	ClinGen ExAC gnomAD
CA352996410 rs1323858064	208	T>I		No	ClinGen gnomAD
rs780939908 CA2372059	208	T>P		No	ClinGen ExAC gnomAD
rs1471973544 CA352996389	212	S>P		No	ClinGen TOPMed
rs368466847 CA74099774	216	D>G		No	ClinGen ESP TOPMed
CA352996349 rs1437849797	217	G>A		No	ClinGen gnomAD
rs758679809 CA2372055	219	V>L		No	ClinGen ExAC gnomAD
rs1166313990 CA352996312	223	D>G		No	ClinGen gnomAD
COSM1692730 CA2372053 rs374368943	223	D>N	Variant assessed as Somatic; 0.0 impact. skin [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
rs1416482643 CA352996307	224	G>R		No	ClinGen TOPMed
rs1020851978 CA352996285	227	L>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs1575269246 CA352996228	233	T>P		No	ClinGen Ensembl
rs368546115 CA2372030	235	S>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs757446929 CA2372027	236	C>F		No	ClinGen ExAC TOPMed gnomAD
rs753832415 CA2372026	238	A>T		No	ClinGen ExAC gnomAD
CA2372025 rs764713762	243	A>G		No	ClinGen ExAC TOPMed gnomAD
CA2372023 rs572329670	247	M>V		No	ClinGen ExAC TOPMed gnomAD
CA352996101 rs1278190917	252	L>F		No	ClinGen gnomAD
rs1453872017 CA352996078	253	D>E		No	ClinGen gnomAD
rs1282758196 CA352996067	255	R>*		No	ClinGen TOPMed gnomAD
rs757533603 CA2372007	255	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs1426856754 CA352996057	256	C>W		No	ClinGen gnomAD
rs777714148 CA2372005	259	F>L		No	ClinGen ExAC TOPMed gnomAD
CA352996023 rs1221874604	261	S>F		No	ClinGen gnomAD
rs1344994486 CA352996017	262	P>H		No	ClinGen gnomAD
rs1344994486 CA352996019	262	P>R		No	ClinGen gnomAD
rs1284058954 CA352996012	263	S>C		No	ClinGen gnomAD
rs753163764 CA2372003	265	C>Y		No	ClinGen ExAC gnomAD
CA352995989 rs1316064498	267	S>P		No	ClinGen TOPMed gnomAD
rs1316064498 CA352995990	267	S>T		No	ClinGen TOPMed gnomAD
CA2372002 rs370021624	268	S>G		No	ClinGen ESP ExAC gnomAD
rs759930362 CA2372001	268	S>T		No	ClinGen ExAC gnomAD
CA74097399 rs892713120	270	R>Q		No	ClinGen TOPMed gnomAD
rs1160952995 CA352995971	270	R>W		No	ClinGen gnomAD
CA352995965 rs1457691309	271	S>L		No	ClinGen TOPMed
CA352995962 rs1575267185	272	V>M		No	ClinGen Ensembl
CA2372000 rs751897112	273	L>W		No	ClinGen ExAC gnomAD
CA352995924 rs1478719805	277	E>G		No	ClinGen TOPMed gnomAD
CA352995918 rs764925971	278	R>L		No	ClinGen ExAC TOPMed gnomAD
rs764925971 CA352995919	278	R>P		No	ClinGen ExAC TOPMed gnomAD
rs764925971 CA2371999	278	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs139580687 CA2371998	279	S>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs200256458 CA2371996	287	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1202146674 CA352995855	288	T>A		No	ClinGen gnomAD
rs760183973 CA2371995	290	R>K		No	ClinGen ExAC gnomAD
CA74097334 rs937509845	294	M>L		No	ClinGen gnomAD
rs1268373128 CA352995783	298	S>I		No	ClinGen gnomAD
rs1429877608 CA352995781	298	S>R		No	ClinGen gnomAD
CA2371993 rs772104840	299	P>S		No	ClinGen ExAC gnomAD
rs1322341488 CA352995774	300	K>E		No	ClinGen gnomAD
rs745707698 CA2371992	300	K>R		No	ClinGen ExAC gnomAD
rs201170431 CA352995765	301	E>G		No	ClinGen ESP ExAC TOPMed gnomAD
CA2371991 rs201170431	301	E>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs771254010 CA2371990	303	T>A		No	ClinGen ExAC TOPMed gnomAD
rs373341230 CA2371989	306	E>D		No	ClinGen ESP ExAC
CA2371986 rs748224977	309	H>R		No	ClinGen ExAC gnomAD
rs1392631890 CA352995457	311	T>S		No	ClinGen TOPMed gnomAD
rs748282795 CA2371967	311	T>S		No	ClinGen ExAC gnomAD
rs1444437184 CA352995449	312	L>F		No	ClinGen gnomAD
CA352995416 rs1414911698	314	Q>R		No	ClinGen gnomAD
rs1002042589 CA74093629	315	S>C		No	ClinGen Ensembl
rs1183940647 CA352995377	317	S>A		No	ClinGen gnomAD
CA2371966 rs141219026	317	S>Y		No	ClinGen 1000Genomes ExAC
CA2371963 rs551768306	318	L>P		No	ClinGen 1000Genomes ExAC gnomAD
CA2371961 rs750770255	320	S>P		No	ClinGen ExAC gnomAD
CA352995339 rs1575262569	320	S>Y		No	ClinGen Ensembl
rs150267735 CA2371960	321	S>F		No	ClinGen ESP ExAC TOPMed gnomAD
rs138476071 CA2371959	322	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs138476071 CA352995312	322	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs202026442 CA2371956	323	K>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1025516505 CA74093570	329	I>V		No	ClinGen Ensembl
rs766305671 CA2371954	331	D>Y		No	ClinGen ExAC gnomAD
rs373510424 CA2371953	332	N>S		No	ClinGen ExAC TOPMed gnomAD
CA352995137 rs1371823897	335	R>M		No	ClinGen gnomAD
TCGA novel	337	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA74092644 rs1023788242	344	G>R		No	ClinGen Ensembl
CA2371931 rs201430835	349	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
rs776869712 CA2371930	350	V>F		No	ClinGen ExAC gnomAD
rs1433833507 CA352994920	351	A>S		No	ClinGen gnomAD
rs1267989083 CA352994919	351	A>V		No	ClinGen gnomAD
rs1192783624 CA352994862	359	Y>D		No	ClinGen gnomAD
rs1184223304 CA352994840	362	P>A		No	ClinGen gnomAD
CA2371928 rs142106531	362	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA352994826 rs1249755586	364	I>V		No	ClinGen gnomAD
rs1257301594 CA352994808	365	M>V		No	ClinGen gnomAD
CA352994800 rs1224575878	366	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs529680138 CA2371910	373	F>L		No	ClinGen 1000Genomes ExAC gnomAD
CA2371909 rs565583599	375	N>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs767652640 CA2371907	378	K>E		No	ClinGen ExAC gnomAD
TCGA novel	380	F>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1404579098 CA352994696	381	V>I		No	ClinGen TOPMed gnomAD
rs1404579098 CA352994697	381	V>L		No	ClinGen TOPMed gnomAD
rs1303046794 CA352994683	383	I>V		No	ClinGen TOPMed gnomAD
CA2371901 rs532141329	392	E>D		No	ClinGen 1000Genomes ExAC gnomAD
rs773575919 CA2371902	392	E>K		No	ClinGen ExAC TOPMed gnomAD
rs1366445708 CA352994603	394	G>D		No	ClinGen gnomAD
rs1490552698 CA352994558	398	G>A		No	ClinGen TOPMed
rs1289775548 CA352994519	404	M>L		No	ClinGen gnomAD
CA2371877 rs376412421	406	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs1259212402 CA352994485	408	V>A	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs745760078 CA2371876	411	F>Y		No	ClinGen ExAC gnomAD
CA74091455 rs749638499	418	V>E		No	ClinGen TOPMed gnomAD
rs879655966 CA352994417	418	V>I		No	ClinGen gnomAD
rs879655966 CA74091460	418	V>L		No	ClinGen gnomAD
rs144093017 CA2371873	420	T>I		No	ClinGen ESP ExAC gnomAD
CA352994339 rs1183786591	430	H>Y		No	ClinGen TOPMed gnomAD
TCGA novel	440	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA352994130 rs1208232296	441	M>I		No	ClinGen gnomAD
CA352994122 rs1346670060	442	C>Y		No	ClinGen Ensembl
CA74088864 rs867146912	443	R>L		No	ClinGen Ensembl
CA352994118 COSM190122 rs1441940642	443	R>W	large_intestine haematopoietic_and_lymphoid_tissue [Cosmic]	No	ClinGen cosmic curated gnomAD
CA2371853 rs747774747	452	G>D		No	ClinGen ExAC gnomAD
CA2371852 rs148722197	457	K>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA74088847 rs1054030001	459	H>Y		No	ClinGen TOPMed
TCGA novel	461	P>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	469	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	470	Y>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	472	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1358182558 CA352993896	475	M>K		No	ClinGen gnomAD
rs1169800358 CA352993841	480	Y>F		No	ClinGen TOPMed
CA2371828 rs746309630	482	E>K		No	ClinGen ExAC gnomAD
CA2371829 rs746309630	482	E>Q		No	ClinGen ExAC gnomAD
CA352993811 rs1463555771	485	S>G		No	ClinGen TOPMed
rs925063767 CA74088629	485	S>N		No	ClinGen TOPMed
CA2371826 rs376309884	487	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs149642245 CA2371827	487	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA gnomAD
CA352993777 rs1219130230	490	H>Y		No	ClinGen gnomAD
TCGA novel	491	H>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs753838385 CA2371825 COSM1045727	492	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
rs753838385 CA74088614	492	E>Q		No	ClinGen ExAC TOPMed gnomAD
CA2371824 rs764271295	493	D>G		No	ClinGen ExAC
rs878906222 CA74088610	494	F>V		No	ClinGen Ensembl
CA2371823 rs756286568	497	D>E		No	ClinGen ExAC TOPMed gnomAD
CA352993707 rs1348217909	500	K>E		No	ClinGen gnomAD
rs766101355 CA2371821	502	R>C	Variant assessed as Somatic; 4.619e-05 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs762736214 CA2371820	502	R>H		No	ClinGen ExAC gnomAD
rs1457746097 CA352993677	504	K>R		No	ClinGen gnomAD
CA352993661 rs1167314662 COSM48275	506	R>Q	lung Variant assessed as Somatic; 0.0 impact. large_intestine [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated NCI-TCGA gnomAD
TCGA novel	506	R>W	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA74088548 rs530558773	509	A>G		No	ClinGen Ensembl
CA352993633 rs1024619739	511	E>K		No	ClinGen TOPMed
CA74088545 rs1024619739	511	E>Q		No	ClinGen TOPMed
rs1222752213 CA352993574	518	Y>C		No	ClinGen TOPMed
CA74088530 rs1023272838	519	S>R		No	ClinGen TOPMed gnomAD
rs768305047 CA2371815	519	S>T		No	ClinGen ExAC gnomAD
TCGA novel	520	R>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA2371814 rs746603686	520	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD

No associated diseases with P30304

1 regional properties for P30304

Type	Name	Position	InterPro Accession
domain	Rhodanese-like domain	366 - 482	IPR001763

Functions

		Description
EC Number	3.1.3.48	Phosphoric monoester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

4 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name	Definition
chaperone binding	Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.
phosphoprotein phosphatase activity	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein tyrosine phosphatase activity	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

10 GO annotations of biological process

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
cell population proliferation	The multiplication or reproduction of cells, resulting in the expansion of a cell population.
cellular response to UV	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
G1/S transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
G2/M transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
positive regulation of G2/M transition of mitotic cell cycle	Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
positive regulation of G2/MI transition of meiotic cell cycle	Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.
regulation of cyclin-dependent protein serine/threonine kinase activity	Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
response to radiation	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P20483	stg	M-phase inducer phosphatase	Drosophila melanogaster (Fruit fly)	PR
P30305	CDC25B	M-phase inducer phosphatase 2	Homo sapiens (Human)	PR
P30306	Cdc25b	M-phase inducer phosphatase 2	Mus musculus (Mouse)	PR
Q336V5	ACR2.1	Arsenate reductase 2.1	Oryza sativa subsp japonica (Rice)	PR

10	20	30	40	50	60
MELGPEPPHR	RRLLFACSPP	PASQPVVKAL	FGASAAGGLS	PVTNLTVTMD	QLQGLGSDYE
70	80	90	100	110	120
QPLEVKNNSN	LQRMGSSEST	DSGFCLDSPG	PLDSKENLEN	PMRRIHSLPQ	KLLGCSPALK
130	140	150	160	170	180
RSHSDSLDHD	IFQLIDPDEN	KENEAFEFKK	PVRPVSRGCL	HSHGLQEGKD	LFTQRQNSAP
190	200	210	220	230	240
ARMLSSNERD	SSEPGNFIPL	FTPQSPVTAT	LSDEDDGFVD	LLDGENLKNE	EETPSCMASL
250	260	270	280	290	300
WTAPLVMRTT	NLDNRCKLFD	SPSLCSSSTR	SVLKRPERSQ	EESPPGSTKR	RKSMSGASPK
310	320	330	340	350	360
ESTNPEKAHE	TLHQSLSLAS	SPKGTIENIL	DNDPRDLIGD	FSKGYLFHTV	AGKHQDLKYI
370	380	390	400	410	420
SPEIMASVLN	GKFANLIKEF	VIIDCRYPYE	YEGGHIKGAV	NLHMEEEVED	FLLKKPIVPT
430	440	450	460	470	480
DGKRVIVVFH	CEFSSERGPR	MCRYVRERDR	LGNEYPKLHY	PELYVLKGGY	KEFFMKCQSY
490	500	510	520
CEPPSYRPMH	HEDFKEDLKK	FRTKSRTWAG	EKSKREMYSR	LKKL