AiPD: Autoinhibited Protein Database

P30305

Gene name	CDC25B (CDC25HU2)
Protein name	M-phase inducer phosphatase 2
Names	Dual specificity phosphatase Cdc25B
Species	Homo sapiens (Human)
KEGG Pathway	hsa:994
EC number	3.1.3.48: Phosphoric monoester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

10-412 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

10-412 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

18 structures for P30305

Entry ID	Method	Resolution	Chain	Position	Source
1CWR	X-ray	210 A	A	370-580	PDB
1CWS	X-ray	200 A	A	370-580	PDB
1CWT	X-ray	230 A	A	388-565	PDB
1QB0	X-ray	191 A	A	370-580	PDB
1YM9	X-ray	200 A	A	391-564	PDB
1YMD	X-ray	170 A	A	391-564	PDB
1YMK	X-ray	170 A	A	391-564	PDB
1YML	X-ray	170 A	A	391-564	PDB
1YS0	X-ray	200 A	A	391-564	PDB
2A2K	X-ray	152 A	A	391-564	PDB
2IFD	X-ray	200 A	A	391-564	PDB
2IFV	X-ray	160 A	A	391-564	PDB
2UZQ	X-ray	238 A	A/B/C/D/E/F	391-580	PDB
3FQT	X-ray	180 A	C	38-46	PDB
3FQU	X-ray	180 A	C	38-46	PDB
4WH7	X-ray	162 A	A	386-565	PDB
4WH9	X-ray	150 A	A	386-565	PDB
AF-P30305-F1	Predicted				AlphaFoldDB

481 variants for P30305

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA408132487 rs1268332789	2	E>*		No	ClinGen gnomAD
rs749466511 CA408132503	4	P>H		No	ClinGen ExAC TOPMed gnomAD
CA9749051 rs749466511	4	P>L		No	ClinGen ExAC TOPMed gnomAD
rs926222369 CA311014815	4	P>S		No	ClinGen TOPMed gnomAD
rs967974676 CA311014817	7	E>D		No	ClinGen TOPMed gnomAD
rs1023527277 CA311014816	7	E>G		No	ClinGen Ensembl
rs1284905190 CA408132518	7	E>K		No	ClinGen TOPMed gnomAD
CA408132519 rs1284905190	7	E>Q		No	ClinGen TOPMed gnomAD
rs1201970854 CA408132526	8	P>S		No	ClinGen gnomAD
rs769072014 CA408132530	9	A>P		No	ClinGen ExAC TOPMed gnomAD
CA9749052 rs769072014	9	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1000681217 CA311014818	12	S>L		No	ClinGen TOPMed gnomAD
CA408132555 rs1240874444	13	A>D		No	ClinGen TOPMed gnomAD
CA408132559 rs1475352534	14	L>V		No	ClinGen gnomAD
CA408132576 rs1479275731	16	P>R		No	ClinGen gnomAD
CA408132572 rs1431879718	16	P>T		No	ClinGen gnomAD
CA311014819 rs892194301	17	A>G		No	ClinGen TOPMed gnomAD
rs1401952090 CA408132586	18	G>D		No	ClinGen gnomAD
rs1483777272 CA408132590	19	V>L		No	ClinGen TOPMed gnomAD
rs1344555862 CA408132606	21	G>A		No	ClinGen gnomAD
CA9749056 rs566288145	23	A>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9749057 rs760242607	24	Q>R		No	ClinGen ExAC TOPMed gnomAD
CA408132628 rs1288089998	25	R>G		No	ClinGen TOPMed
CA9749059 rs765859923	26	P>L		No	ClinGen ExAC TOPMed gnomAD
rs1245846993 CA408132646	28	H>Y		No	ClinGen TOPMed
rs753500619 CA9749060	30	P>R		No	ClinGen ExAC gnomAD
rs765110297 CA9749062	33	L>P		No	ClinGen ExAC gnomAD
TCGA novel	37	H>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1208519927 CA408132698	37	H>Y		No	ClinGen Ensembl
rs1470930772 CA408132725	41	G>A		No	ClinGen gnomAD
CA408132722 rs1364049086	41	G>R		No	ClinGen TOPMed gnomAD
CA9749065 rs777925717	43	P>L		No	ClinGen ExAC gnomAD
rs985447020 CA311014820	45	R>W		No	ClinGen Ensembl
rs1361496689 CA408132751	46	A>V		No	ClinGen TOPMed
rs1165375545 CA408132762	48	A>S		No	ClinGen TOPMed gnomAD
rs756278897 CA9749067	50	S>L		No	ClinGen ExAC gnomAD
rs1418387610 CA408132794	53	T>I		No	ClinGen TOPMed
CA408132802 rs911457532	55	L>F		No	ClinGen TOPMed gnomAD
rs911457532 CA311014821	55	L>V		No	ClinGen TOPMed gnomAD
rs780219390 CA9749068	56	T>A		No	ClinGen ExAC TOPMed gnomAD
CA408132809 rs1473609407	56	T>S		No	ClinGen TOPMed
CA408132820 rs1038934474	58	T>A		No	ClinGen gnomAD
rs768716565 CA9749070	58	T>I		No	ClinGen ExAC gnomAD
CA311014822 rs1038934474	58	T>S		No	ClinGen gnomAD
rs1357841475 CA408132828 CA408132829	59	M>I		No	ClinGen gnomAD
CA9749072 rs748498041	59	M>K		No	ClinGen ExAC gnomAD
CA9749071 rs372183442	59	M>V		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749073 rs772477590	62	L>F		No	ClinGen ExAC gnomAD
rs145700972 CA9749074	63	A>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA408132860 rs1231865477	64	G>V		No	ClinGen gnomAD
rs570035703 CA311014823	66	G>D		No	ClinGen 1000Genomes gnomAD
rs769335539 CA9749097	67	S>R		No	ClinGen ExAC TOPMed gnomAD
CA408132989 rs1460475673	68	E>D		No	ClinGen gnomAD
CA9749099 rs762603447	68	E>K		No	ClinGen ExAC TOPMed gnomAD
CA9749100 rs373910055	69	T>I		No	ClinGen ESP ExAC gnomAD
rs987818882 CA311014992	71	K>E		No	ClinGen TOPMed gnomAD
rs778400837 CA408133030	71	K>N		No	ClinGen TOPMed
CA9749102 rs761683237	73	Q>L		No	ClinGen ExAC gnomAD
CA408133072 rs1429692455	74	V>A		No	ClinGen gnomAD
rs565873590 CA311014994	74	V>I		No	ClinGen 1000Genomes
CA9749104 rs202156665	79	F>C		No	ClinGen 1000Genomes TOPMed
rs750367173 CA9749106	80	R>C		No	ClinGen ExAC TOPMed gnomAD
CA408133147 rs76772959	80	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs76772959 CA311014995	80	R>P		No	ClinGen TOPMed gnomAD
CA9749108 rs778990892	82	R>C		No	ClinGen ExAC TOPMed gnomAD
rs146567070 CA311014997	82	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP NCI-TCGA TOPMed gnomAD
rs146567070 CA408133177	82	R>L		No	ClinGen ESP TOPMed gnomAD
rs1298017938 CA408133199	84	R>C		No	ClinGen TOPMed gnomAD
CA311014999 COSM3783485 rs866490685	84	R>H	Variant assessed as Somatic; 0.0 impact. prostate [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA408133211 rs1600389582	85	L>P		No	ClinGen Ensembl
rs554867030 CA9749109	86	T>M		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs554867030 CA9749110	86	T>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9749113 rs370072424	87	H>Q		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749111 rs375803588	87	H>R		No	ClinGen ESP ExAC TOPMed gnomAD
rs769194857 CA9749116	91	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs895721277 CA311015006	92	R>P		No	ClinGen TOPMed
CA408133295 rs762720996	93	R>P		No	ClinGen ExAC TOPMed gnomAD
CA9749118 rs762720996	93	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9749117 rs775028130	93	R>W		No	ClinGen ExAC gnomAD
CA9749119 rs543058694	95	S>F		No	ClinGen 1000Genomes ExAC gnomAD
rs761763027 CA9749121 COSM1026752	96	E>K	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA408133341 rs1425997425	97	S>F		No	ClinGen gnomAD
CA408133327 rs1187793934	97	S>T		No	ClinGen gnomAD
rs1425997425 CA408133338	97	S>Y		No	ClinGen gnomAD
CA408133351 rs1158563910	98	S>F		No	ClinGen gnomAD
CA408133374 rs1318988173	100	S>L		No	ClinGen TOPMed
rs760592747 CA9749124	103	S>Y		No	ClinGen ExAC gnomAD
CA9749128 rs778037198	105	E>A		No	ClinGen ExAC gnomAD
rs1238719685 CA408133441	105	E>D		No	ClinGen gnomAD
rs199501910 CA9749127	105	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
CA9749129 rs751768391	106	S>Y		No	ClinGen ExAC TOPMed gnomAD
rs1323636824 CA408133475	109	A>T		No	ClinGen TOPMed
CA408133485 rs1220000106 COSM1495089	109	A>V	kidney [Cosmic]	No	ClinGen cosmic curated gnomAD
CA408133490 rs1488303200	110	G>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs973112376 CA311015118	115	S>F	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs1319699734 CA408133627	117	S>N		No	ClinGen TOPMed
CA408133629 rs780682683	117	S>R		No	ClinGen ExAC TOPMed gnomAD
CA311015124 rs950692418	119	M>V		No	ClinGen Ensembl
rs749796277 CA9749152	120	D>G		No	ClinGen ExAC gnomAD
CA9749153 rs754545392	121	P>A		No	ClinGen ExAC gnomAD
rs754545392 CA9749154	121	P>T		No	ClinGen ExAC gnomAD
rs564744524 CA9749155	123	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs376436608 CA9749156	124	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1407654117 CA408133681	125	E>G		No	ClinGen gnomAD
CA9749159 rs141382375	126	Q>K		No	ClinGen ESP ExAC TOPMed gnomAD
rs370155414 CA9749161	127	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749186 rs577575183	130	Q>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9749187 rs759959605	130	Q>R		No	ClinGen ExAC gnomAD
rs545103594 CA9749188	131	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA9749190 rs757939295	132	I>V		No	ClinGen ExAC TOPMed gnomAD
rs1347673573 CA408134068	133	Q>R		No	ClinGen gnomAD
CA311015588 rs976549421	134	A>T		No	ClinGen gnomAD
CA9749192 rs143386679	137	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs137919521 CA9749191	137	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1367767267 CA408134120	138	I>L		No	ClinGen TOPMed
rs1284511439 CA408134135	139	I>V		No	ClinGen gnomAD
CA9749194 rs780797924	140	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9749196 rs143369164	140	R>P		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9749195 rs143369164	140	R>Q		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9749212 rs767220701	142	E>K		No	ClinGen ExAC TOPMed gnomAD
rs750060566 CA9749213	144	F>L		No	ClinGen ExAC gnomAD
rs111654983 CA311015635	145	A>D		No	ClinGen TOPMed
CA311015633 rs968527639	145	A>T		No	ClinGen TOPMed
CA311015637 rs111654983	145	A>V		No	ClinGen TOPMed
rs755912697 CA408134274	146	I>M		No	ClinGen ExAC gnomAD
rs1445234666 CA408134263	146	I>V		No	ClinGen gnomAD
rs147172963 CA9749215	148	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749216 rs371528141	148	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
CA9749217 rs371528141	148	R>P		No	ClinGen ESP ExAC TOPMed gnomAD
rs61755298 CA9749218	150	Q>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749220 rs771131604	151	S>F		No	ClinGen ExAC gnomAD
CA408134348 rs1219211410	152	M>T		No	ClinGen gnomAD
rs140433155 COSM3740131 CA9749222	152	M>V	liver [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs775666911 CA9749224	153	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs770312291 CA9749223	153	P>T		No	ClinGen ExAC TOPMed gnomAD
CA9749248 rs762236479	155	R>S		No	ClinGen ExAC TOPMed gnomAD
CA408134710 rs1234813756	158	G>V		No	ClinGen gnomAD
rs1253718392 CA408134716	159	H>N		No	ClinGen gnomAD
CA9749249 rs771606389	161	P>L		No	ClinGen ExAC gnomAD
CA408134753 rs375465916	162	V>L		No	ClinGen ESP ExAC TOPMed gnomAD
COSM1026754 rs375465916 CA9749252	162	V>M	Variant assessed as Somatic; 0.0 impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA311015716 rs201911534	163	L>F		No	ClinGen 1000Genomes gnomAD
rs538158719 CA9749254	164	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA gnomAD
rs371350767 CA9749253	164	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749255 rs765024374	165	N>D		No	ClinGen ExAC gnomAD
rs752711886 CA9749256	168	N>S		No	ClinGen ExAC gnomAD
rs752711886 CA408134826	168	N>T		No	ClinGen ExAC gnomAD
rs758361574 CA9749257	169	S>F		No	ClinGen ExAC TOPMed gnomAD
CA408134862 rs373068861	171	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA408134861 rs1362931742	171	A>S		No	ClinGen gnomAD
CA9749258 rs373068861	171	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1195699094 CA408134866	172	P>S		No	ClinGen TOPMed
CA9749261 rs780196030	173	D>N		No	ClinGen ExAC TOPMed gnomAD
CA9749263 rs367573455	174	G>S		No	ClinGen ExAC TOPMed gnomAD
rs779300536 CA9749265	175	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9749266 rs144359318	175	R>Q		No	ClinGen ESP ExAC TOPMed gnomAD
rs779300536 CA9749264	175	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1215687252 CA408134885	176	R>K		No	ClinGen gnomAD
rs773681532 CA9749267	176	R>W		No	ClinGen ExAC gnomAD
rs199988612 CA9749268	177	K>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA408134894 rs1271716601	177	K>R		No	ClinGen TOPMed
rs1600398234 CA408134900	178	S>G		No	ClinGen Ensembl
CA408134901 rs1224909117	178	S>N		No	ClinGen TOPMed
CA9749269 rs770463028	179	E>K	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA311015742 rs920383476	180	A>G		No	ClinGen TOPMed gnomAD
CA311015740 rs773393529	180	A>S		No	ClinGen TOPMed gnomAD
rs920383476 CA408134931	180	A>V		No	ClinGen TOPMed gnomAD
CA9749271 rs759162155	181	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1382726900 CA408134934	181	G>S		No	ClinGen gnomAD
CA408134959 rs1158462370	182	S>R		No	ClinGen TOPMed gnomAD
rs577638878 CA9749272	183	G>E		No	ClinGen 1000Genomes ExAC gnomAD
CA408134977 rs1459178713	184	A>V		No	ClinGen gnomAD
CA311015748 rs1052778969	185	A>T		No	ClinGen gnomAD
rs1568508083 CA408134992	185	A>V		No	ClinGen Ensembl
CA9749275 rs538614130	186	S>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs751526183 CA9749276	186	S>I		No	ClinGen ExAC gnomAD
CA311015754 rs536795359	187	S>R		No	ClinGen Ensembl
CA9749278 rs780110600	188	S>F		No	ClinGen ExAC TOPMed gnomAD
rs755182399 CA9749280	190	E>D		No	ClinGen ExAC gnomAD
CA9749279 rs754035549	190	E>K		No	ClinGen ExAC TOPMed gnomAD
CA408135051 rs1600398432	190	E>V		No	ClinGen Ensembl
rs1471994483 CA408135063	191	D>V		No	ClinGen gnomAD
CA408135098 rs1266143183	193	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs939335268 CA311015760	194	N>K		No	ClinGen TOPMed
rs1445694084 CA408135163	195	D>N		No	ClinGen gnomAD
CA9749303 rs202155757	196	G>A		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs202155757 CA9749304	196	G>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
TCGA novel	197	F>C	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408135201 rs1362384161	198	V>I		No	ClinGen gnomAD
CA408135292 rs1316254185	206	T>A		No	ClinGen gnomAD
CA9749306 rs765071084	207	H>Y		No	ClinGen ExAC gnomAD
rs919329789 CA311015792	210	S>F		No	ClinGen Ensembl
rs368042199 CA311015796	211	T>A		No	ClinGen ESP
rs781519537 CA9749308	212	H>R		No	ClinGen ExAC gnomAD
rs1237351161 CA408135337	213	A>G		No	ClinGen gnomAD
CA9749309 rs540104946	213	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs540104946 CA9749310	213	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs775293101 CA9749311	216	E>G		No	ClinGen ExAC
rs748880746 CA9749312	217	W>G		No	ClinGen ExAC
rs142459784 CA9749313	218	A>P		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749314 rs142459784	218	A>S		No	ClinGen ESP ExAC TOPMed gnomAD
rs761494790 CA9749315 COSM216489	220	R>C	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs767534464 CA9749317	220	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9749316 rs767534464	220	R>L		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	222	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA9749319 rs765244196	223	A>V		No	ClinGen ExAC
CA9749320 rs752923615	224	F>C		No	ClinGen ExAC TOPMed gnomAD
CA311015809 rs200968688	224	F>L		No	ClinGen 1000Genomes
CA9749321 rs758579174	226	Q>R		No	ClinGen ExAC gnomAD
rs764466123 CA311015813	228	P>A		No	ClinGen ExAC TOPMed gnomAD
CA9749323 rs751994016	228	P>L		No	ClinGen ExAC gnomAD
rs764466123 CA9749322	228	P>S		No	ClinGen ExAC TOPMed gnomAD
rs1361020932 CA408135433	229	S>T		No	ClinGen gnomAD
rs573830932 CA9749324	230	S>L		No	ClinGen 1000Genomes ExAC gnomAD
rs746300504 CA408135454	233	D>H		No	ClinGen ExAC TOPMed gnomAD
rs746300504 CA9749326	233	D>N		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	233	D>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	233	D>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1275572437 CA408135468	235	M>L		No	ClinGen gnomAD
rs1275572437 CA408135467	235	M>V		No	ClinGen gnomAD
CA408135489 rs1387816774	236	C>R		No	ClinGen gnomAD
TCGA novel	237	L>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs111545759 CA311015864	238	S>G		No	ClinGen TOPMed
CA9749352 rs771906162	238	S>I		No	ClinGen ExAC TOPMed gnomAD
rs1238243216 CA408135507	239	P>T		No	ClinGen gnomAD
CA9749353 rs751070261	240	D>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs201435494 CA9749355	241	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA9749354 rs202222511	241	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA408135535 rs1164728004	243	M>T		No	ClinGen gnomAD
rs1416292708 CA408135548	245	V>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1403783969 CA408135562	247	E>K		No	ClinGen TOPMed gnomAD
CA408135576 rs1325386712	249	S>R		No	ClinGen gnomAD
CA408135586 rs1401107710	250	P>S		No	ClinGen gnomAD
rs763078027 CA9749357	251	L>V		No	ClinGen ExAC gnomAD
rs768561202 CA9749359	254	G>D		No	ClinGen ExAC TOPMed gnomAD
CA9749360 rs774633750	255	R>C		No	ClinGen ExAC TOPMed gnomAD
CA9749361 rs151315259	255	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA408135613 rs151315259	255	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs372916640 CA9749362	259	T>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA311015878 rs202059655	260	P>S		No	ClinGen gnomAD
CA408135638 rs202059655	260	P>T		No	ClinGen gnomAD
CA9749364 rs139531565	261	A>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1568509072 CA408135643	261	A>T		No	ClinGen Ensembl
CA9749365 rs139531565	261	A>V		No	ClinGen ESP ExAC TOPMed gnomAD
rs1365603747 CA408135651	262	E>G		No	ClinGen TOPMed gnomAD
CA9749367 rs754553191	266	E>Q		No	ClinGen ExAC gnomAD
rs1027798125 CA311015882	267	E>K		No	ClinGen TOPMed gnomAD
rs934948129 CA311015884 CA408135702	269	D>E		No	ClinGen TOPMed
TCGA novel	269	D>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs778219991 CA9749368	269	D>V		No	ClinGen ExAC gnomAD
CA9749370 rs757940894	273	D>G		No	ClinGen ExAC gnomAD
CA9749371 rs554137303	274	I>M		No	ClinGen 1000Genomes ExAC gnomAD
CA9749373 rs373171092	279	L>V		No	ClinGen ESP ExAC gnomAD
rs1568509442 CA408135804	282	D>G		No	ClinGen Ensembl
rs757896188 CA9749388	284	A>S		No	ClinGen ExAC TOPMed gnomAD
CA9749389 rs144187197	286	P>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs779320071 CA311015957	286	P>L		No	ClinGen TOPMed gnomAD
rs751152699 CA9749390	287	P>L		No	ClinGen ExAC gnomAD
CA408135871 rs1342030822	288	G>R		No	ClinGen gnomAD
CA408135879 rs1397743426	288	G>V		No	ClinGen gnomAD
CA9749391 rs757050439	291	S>R		No	ClinGen ExAC gnomAD
rs1234700870 CA408135956	294	S>G		No	ClinGen gnomAD
CA408135996 rs1273041674	297	L>R		No	ClinGen gnomAD
CA408136029 rs1489433928	300	T>N		No	ClinGen TOPMed gnomAD
CA408136031 rs1489433928	300	T>S		No	ClinGen TOPMed gnomAD
CA9749396 rs201902192	304	E>K		No	ClinGen 1000Genomes ExAC gnomAD
rs1393083295 CA408136189	308	D>G		No	ClinGen gnomAD
CA311015985 rs753753363	309	L>F		No	ClinGen ExAC gnomAD
rs753753363 CA9749413	309	L>V		No	ClinGen ExAC gnomAD
rs547724975 CA9749415 COSM178795	310	V>I	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC NCI-TCGA TOPMed gnomAD
CA408136252 rs1313119421	313	S>G		No	ClinGen gnomAD
rs1322621683 CA408136264	313	S>R		No	ClinGen TOPMed gnomAD
rs1247242758 CA408136270	314	K>E		No	ClinGen gnomAD
CA408136275 rs1271441616	314	K>N		No	ClinGen gnomAD
CA9749416 rs200104998	315	C>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA408136293 rs1240598537	317	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA311015986 rs536184837	317	R>W		No	ClinGen TOPMed gnomAD
rs771328061 CA9749417	318	L>F		No	ClinGen ExAC TOPMed gnomAD
CA9749418 rs781536119	318	L>H		No	ClinGen ExAC gnomAD
CA408136297 rs771328061	318	L>V		No	ClinGen ExAC TOPMed gnomAD
CA9749420 rs141314132	320	R>C		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749421 rs775863316	320	R>H		No	ClinGen ExAC gnomAD
CA408136326 rs1416655450	321	S>F		No	ClinGen gnomAD
CA311015989 rs375465349	322	P>L		No	ClinGen TOPMed gnomAD
CA408136335 rs375465349	322	P>R		No	ClinGen TOPMed gnomAD
CA408136361 rs1303269559	324	M>T		No	ClinGen gnomAD
rs371407165 CA9749425	324	M>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs149795416 CA9749427	328	V>M		No	ClinGen ESP ExAC TOPMed gnomAD
rs1219380120 CA408136433	329	I>M	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA408136435 rs376224294	330	R>G		No	ClinGen ESP ExAC TOPMed gnomAD
rs766135561 CA408136437	330	R>L		No	ClinGen ExAC TOPMed gnomAD
rs766135561 CA9749429	330	R>Q		No	ClinGen ExAC TOPMed gnomAD
CA9749428 rs376224294	330	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA408136449 rs1204429629	331	P>S		No	ClinGen gnomAD
CA408136469 rs1257045310	332	I>M		No	ClinGen TOPMed gnomAD
rs1484447777 CA408136475	333	L>F		No	ClinGen gnomAD
rs754915160 CA9749431	334	K>R		No	ClinGen ExAC TOPMed gnomAD
CA408136535 rs1416753572	338	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA9749432 rs778972862	338	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1360786034 CA408136557	340	Q>*		No	ClinGen gnomAD
CA311015995 rs912667905	342	R>G		No	ClinGen TOPMed
CA408136591 rs1464377536	342	R>S		No	ClinGen gnomAD
CA408136602 rs1317167566	343	D>E		No	ClinGen TOPMed
rs757410261 CA9749434	343	D>N		No	ClinGen ExAC TOPMed gnomAD
CA408136609 rs781283576	344	T>A		No	ClinGen ExAC TOPMed gnomAD
rs369403610 CA311015996	344	T>M		No	ClinGen ESP TOPMed gnomAD
rs781283576 CA9749435	344	T>S		No	ClinGen ExAC TOPMed gnomAD
rs570142869 CA311015997	345	P>A		No	ClinGen 1000Genomes gnomAD
CA311015998 rs756602132	345	P>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen Ensembl NCI-TCGA
CA9749440 rs769187828	346	V>M		No	ClinGen ExAC TOPMed gnomAD
CA408136648 rs1314431387	347	Q>R		No	ClinGen gnomAD
rs774833241 CA9749441	348	N>S		No	ClinGen ExAC gnomAD
CA9749442 rs761367283	350	R>Q		No	ClinGen ExAC gnomAD
rs376488245 CA9749443	351	R>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749445 rs2228465	351	R>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
COSM443811 CA408136709 rs1191220801	352	R>Q	Variant assessed as Somatic; 0.0 impact. breast [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA gnomAD
CA9749446 rs577722969	352	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA408136717 rs1452468464	353	S>G		No	ClinGen TOPMed gnomAD
CA408136730 rs886075503	354	V>L		No	ClinGen TOPMed gnomAD
rs886075503 CA311016000	354	V>M		No	ClinGen TOPMed gnomAD
CA408136755 rs765333514	356	P>S		No	ClinGen ExAC TOPMed gnomAD
CA9749449 rs765333514	356	P>T		No	ClinGen ExAC TOPMed gnomAD
rs1263651599 CA408136766	357	P>S		No	ClinGen TOPMed
rs1430158059 CA408136825	361	Q>L		No	ClinGen gnomAD
rs1294170557 CA408136832	362	E>K		No	ClinGen gnomAD
CA311016001 rs1004520342	363	A>T		No	ClinGen TOPMed
CA9749450 rs752670696	365	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1332045888 CA408136954	368	A>T		No	ClinGen gnomAD
CA408136962 rs1212464885	368	A>V		No	ClinGen gnomAD
CA9749463 rs772733349	369	R>C		No	ClinGen ExAC TOPMed gnomAD
rs746480347 CA9749464	369	R>H	Variant assessed as Somatic; 0.0002086 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9749466 rs771067354	370	V>I		No	ClinGen ExAC TOPMed gnomAD
CA408136991 rs1156444624	371	L>F		No	ClinGen TOPMed
rs1420231272 CA408137001	372	R>C		No	ClinGen gnomAD
rs374005977 CA9749469	372	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
rs374005977 CA408137004	372	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs762934301 CA9749470	375	S>L		No	ClinGen ExAC TOPMed gnomAD
rs929612033 CA311016046	376	L>P		No	ClinGen Ensembl
rs763915479 CA9749471	376	L>V		No	ClinGen ExAC gnomAD
rs756139248 CA9749473	377	C>Y		No	ClinGen ExAC gnomAD
rs560679507 CA408137076	378	H>Q		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs531304165 CA9749475	379	D>N		No	ClinGen 1000Genomes ExAC gnomAD
CA9749476 rs755342511	379	D>V		No	ClinGen ExAC TOPMed gnomAD
rs964193804 CA311016052	380	E>A		No	ClinGen TOPMed gnomAD
rs748679556 CA9749478	382	E>K		No	ClinGen ExAC TOPMed
rs1483841139 CA634192012	382	E>VF*		No	ClinGen gnomAD
CA408137145 rs1600403120	383	N>I		No	ClinGen Ensembl
rs376924240 CA9749479	384	L>F		No	ClinGen ESP ExAC gnomAD
rs376924240 CA408137154	384	L>I		No	ClinGen ESP ExAC gnomAD
CA408137192 rs1353170287	386	D>E		No	ClinGen TOPMed
CA408137178 rs1189313393	386	D>N		No	ClinGen TOPMed gnomAD
CA408137181 rs1189313393	386	D>Y		No	ClinGen TOPMed gnomAD
rs1259923964 CA408137196	387	S>G		No	ClinGen TOPMed gnomAD
CA408137201 rs1474336302	387	S>N		No	ClinGen gnomAD
rs138180783 CA9749481	390	R>*		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749482 rs770335566	390	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs1396339380 CA408137338	398	K>E		No	ClinGen gnomAD
CA408137654 rs1358801506	403	Q>E		No	ClinGen TOPMed
TCGA novel	405	V>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	406	D>E	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs768275270 COSM1644485 CA9749509	407	G>R	salivary_gland [Cosmic]	No	ClinGen cosmic curated ExAC gnomAD
rs1202056050 CA408137687	408	K>E		No	ClinGen TOPMed gnomAD
CA408137740 rs980490967	415	I>L		No	ClinGen Ensembl
CA311016197 rs980490967	415	I>V		No	ClinGen Ensembl
rs771068008 CA9749513	419	T>A		No	ClinGen ExAC gnomAD
CA311016200 rs779594383	419	T>M		No	ClinGen TOPMed gnomAD
rs376914644 CA9749545	425	T>M		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	426	G>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408137859 rs1185231292	431	I>V		No	ClinGen gnomAD
rs199832947 CA311016231	432	V>M		No	ClinGen Ensembl
CA9749551 rs570843479	434	K>T		No	ClinGen 1000Genomes ExAC gnomAD
CA9749552 rs769895609	437	I>T		No	ClinGen ExAC TOPMed gnomAD
rs1303192290 CA408137908	438	V>A		No	ClinGen gnomAD
CA9749553 rs775478838	438	V>L		No	ClinGen ExAC gnomAD
rs1386534890 CA408137949	444	Y>D		No	ClinGen TOPMed
rs1298412898 CA408138005	451	I>M		No	ClinGen gnomAD
rs1306235409 CA408138010	452	K>R		No	ClinGen gnomAD
CA9749582 rs764741960	454	A>V		No	ClinGen ExAC TOPMed gnomAD
rs752380335 CA9749583	455	V>G		No	ClinGen ExAC
CA408138037 rs1209329373	455	V>L		No	ClinGen TOPMed gnomAD
rs377681163 CA9749584	461	R>C	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
CA9749585 rs138651339	461	R>H		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749587 rs61742036	462	D>N		No	ClinGen ExAC gnomAD
CA311016279 rs61742036	462	D>Y		No	ClinGen ExAC gnomAD
rs1439228793 CA408138140	463	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs755042639 TCGA novel CA9749590	464	E>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA ClinGen ExAC gnomAD
rs779001037 CA9749591	465	S>I		No	ClinGen ExAC TOPMed gnomAD
CA408138273 rs1275017229	470	S>I		No	ClinGen TOPMed gnomAD
CA408138270 rs1275017229	470	S>N		No	ClinGen TOPMed gnomAD
rs778137288 CA9749595	470	S>R		No	ClinGen ExAC TOPMed gnomAD
CA408138283 rs1297710989	471	P>A		No	ClinGen Ensembl
rs370128666 CA9749596	472	I>V		No	ClinGen ExAC TOPMed gnomAD
rs760051246 CA9749598	473	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9749599 rs61755297	473	A>V		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA9749602 rs763791017	474	P>A		No	ClinGen ExAC gnomAD
rs1354804778 CA408138383	478	D>H		No	ClinGen TOPMed
rs761775118 CA311016295	479	K>R		No	ClinGen TOPMed gnomAD
CA311016299 rs561482953	481	V>D		No	ClinGen Ensembl
CA9749604 rs761517361	482	I>V		No	ClinGen ExAC TOPMed gnomAD
rs750349157 CA9749606	484	I>V		No	ClinGen ExAC gnomAD
rs756124163 CA9749607	486	H>R		No	ClinGen ExAC gnomAD
rs1277440232 CA408138535	486	H>Y		No	ClinGen gnomAD
rs1343953313 CA408138550	487	C>R		No	ClinGen gnomAD
COSM1026758 CA408138609 rs1399244459	489	F>L	Variant assessed as Somatic; impact. endometrium [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated NCI-TCGA TOPMed
CA408138639 rs1350254777	491	S>P		No	ClinGen TOPMed
CA9749608 rs780111315	492	E>Q		No	ClinGen ExAC
CA408138698 rs1332665483	493	R>H		No	ClinGen TOPMed gnomAD
rs1332665483 CA408138699	493	R>L		No	ClinGen TOPMed gnomAD
rs199659921 CA9749610	496	R>C		No	ClinGen ExAC gnomAD
rs200957584 CA311016308	496	R>P		No	ClinGen Ensembl
CA408139041 rs1373210915	497	M>I		No	ClinGen gnomAD
CA408139051 rs1394997385	498	C>Y		No	ClinGen gnomAD
CA408139073 rs1318395398	499	R>C		No	ClinGen gnomAD
CA9749636 COSM3379053 rs547890760	499	R>H	pancreas [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA408139189 rs1296707909	503	E>K		No	ClinGen gnomAD
rs1016651486 CA311016597	504	R>*		No	ClinGen TOPMed gnomAD
rs1016651486 CA408139220	504	R>G		No	ClinGen TOPMed gnomAD
rs1600409240 CA408139242	505	D>A		No	ClinGen Ensembl
CA311016599 rs966968317	506	R>C		No	ClinGen Ensembl
rs1332035758 CA408139298	507	A>D		No	ClinGen TOPMed
CA408139293 rs1236174031	507	A>T		No	ClinGen gnomAD
CA9749637 rs780540065	509	N>S		No	ClinGen ExAC gnomAD
CA9749641 rs773898396	510	D>A		No	ClinGen ExAC gnomAD
CA9749640 rs768175818	510	D>N		No	ClinGen ExAC TOPMed
CA9749642 rs747578238	511	Y>S		No	ClinGen ExAC gnomAD
rs1161841965 CA408139416	512	P>S		No	ClinGen TOPMed gnomAD
rs1429736603 CA408139445	513	S>C		No	ClinGen TOPMed
CA408139453 rs1331672189	513	S>T		No	ClinGen TOPMed
rs1568513640 CA408139686	523	K>E		No	ClinGen Ensembl
TCGA novel	524	G>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408139728 rs1247893759	525	G>S		No	ClinGen gnomAD
rs1455012842 CA408139792	527	K>E		No	ClinGen gnomAD
CA311016602 rs993987233	527	K>R		No	ClinGen TOPMed
CA408139856 rs1175897100	528	E>D		No	ClinGen gnomAD
rs1164242664 CA408139947	531	P>L		No	ClinGen TOPMed
rs1466367199 CA408139958	532	Q>*		No	ClinGen TOPMed
rs1421878327 CA408140021	533	H>R		No	ClinGen TOPMed
rs760533388 CA9749645	534	P>L		No	ClinGen ExAC TOPMed gnomAD
CA408140040 rs760533388	534	P>Q		No	ClinGen ExAC TOPMed gnomAD
rs930279721 CA311016609	535	N>Y		No	ClinGen Ensembl
CA9749663 rs746605447	536	F>L		No	ClinGen ExAC gnomAD
CA408140947 rs1309870780	537	C>*		No	ClinGen TOPMed
rs1225328024 CA408140950	538	E>K		No	ClinGen TOPMed
CA311016610 rs1040579784	540	Q>P		No	ClinGen TOPMed gnomAD
CA9749666 rs759376867	541	D>N		No	ClinGen ExAC gnomAD
TCGA novel	543	R>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA408141049 rs1287808358	543	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
CA408141048 rs1226716178	543	R>W		No	ClinGen TOPMed gnomAD
rs923513236 CA311016612	544	P>S		No	ClinGen TOPMed
rs11570019 CA9749669 VAR_020933	548	E>K		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1568514013 CA408141151	549	A>D		No	ClinGen Ensembl
CA408141202 rs1252288685	551	K>E		No	ClinGen gnomAD
CA634192638 rs1180911168	552	D>ASSLCR*		No	ClinGen gnomAD
rs1176087397 CA408141229	552	D>H		No	ClinGen TOPMed
CA9749673 rs766556021	558	R>C		No	ClinGen ExAC TOPMed gnomAD
rs1299657974 CA408141392	558	R>H		No	ClinGen gnomAD
rs1307593913 CA408141448	561	T>A		No	ClinGen gnomAD
rs779489769 CA9749676	562	R>C		No	ClinGen ExAC TOPMed gnomAD
rs779489769 CA408141465	562	R>G		No	ClinGen ExAC TOPMed gnomAD
rs753080001 CA408141468	562	R>H		No	ClinGen ExAC TOPMed gnomAD
rs753080001 CA9749677	562	R>P		No	ClinGen ExAC TOPMed gnomAD
rs1321621733 CA408141520	565	A>S		No	ClinGen gnomAD
CA9749679 rs371947700	567	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA9749681 rs770749593	568	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs746499541 CA9749680	568	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA9749682 rs514523	569	S>N		No	ClinGen ESP ExAC gnomAD
rs514521 CA408141598 CA311016615	569	S>R		No	ClinGen gnomAD
rs514523 CA311016614	569	S>T		No	ClinGen ESP ExAC gnomAD
rs758797782 CA408141604	570	R>G		No	ClinGen ExAC TOPMed gnomAD
CA9749685 rs769405661	570	R>P		No	ClinGen ExAC gnomAD
CA9749684 rs769405661	570	R>Q		No	ClinGen ExAC gnomAD
rs758797782 CA9749683	570	R>W		No	ClinGen ExAC TOPMed gnomAD
CA9749687 rs768615877	571	R>Q		No	ClinGen ExAC gnomAD
CA9749686 rs762747082	571	R>W		No	ClinGen ExAC TOPMed gnomAD
rs1600410573 CA408141618	572	E>G		No	ClinGen Ensembl
CA311016616 rs550652694	575	S>C		No	ClinGen 1000Genomes
CA408141696 rs760737511	576	R>L		No	ClinGen ExAC gnomAD
CA9749689 rs760737511	576	R>Q		No	ClinGen ExAC gnomAD
rs369357260 CA9749688	576	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
CA408141720 rs1568514303	578	Q>*		No	ClinGen Ensembl
rs200551395 CA9749691	580	Q>R		No	ClinGen 1000Genomes ExAC TOPMed gnomAD

No associated diseases with P30305

1 regional properties for P30305

Type	Name	Position	InterPro Accession
domain	Rhodanese-like domain	421 - 538	IPR001763

Functions

		Description
EC Number	3.1.3.48	Phosphoric monoester hydrolases
Subcellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

6 GO annotations of cellular component

Name	Definition
centrosome	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
spindle pole	Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.

3 GO annotations of molecular function

Name	Definition
phosphoprotein phosphatase activity	Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity.
protein kinase binding	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
protein tyrosine phosphatase activity	Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

13 GO annotations of biological process

Name	Definition
cell division	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
female meiosis I	The cell cycle process in which the first meiotic division occurs in the female germline.
G2/M transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
oocyte maturation	A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
positive regulation of cell population proliferation	Any process that activates or increases the rate or extent of cell proliferation.
positive regulation of cytokinesis	Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.
positive regulation of G2/M transition of mitotic cell cycle	Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
positive regulation of G2/MI transition of meiotic cell cycle	Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.
positive regulation of mitotic cell cycle	Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.
positive regulation of protein kinase activity	Any process that activates or increases the frequency, rate or extent of protein kinase activity.
protein dephosphorylation	The process of removing one or more phosphoric residues from a protein.
protein phosphorylation	The process of introducing a phosphate group on to a protein.

4 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P20483	stg	M-phase inducer phosphatase	Drosophila melanogaster (Fruit fly)	PR
P30304	CDC25A	M-phase inducer phosphatase 1	Homo sapiens (Human)	PR
P30306	Cdc25b	M-phase inducer phosphatase 2	Mus musculus (Mouse)	PR
Q336V5	ACR2.1	Arsenate reductase 2.1	Oryza sativa subsp japonica (Rice)	PR

10	20	30	40	50	60
MEVPQPEPAP	GSALSPAGVC	GGAQRPGHLP	GLLLGSHGLL	GSPVRAAASS	PVTTLTQTMH
70	80	90	100	110	120
DLAGLGSETP	KSQVGTLLFR	SRSRLTHLSL	SRRASESSLS	SESSESSDAG	LCMDSPSPMD
130	140	150	160	170	180
PHMAEQTFEQ	AIQAASRIIR	NEQFAIRRFQ	SMPVRLLGHS	PVLRNITNSQ	APDGRRKSEA
190	200	210	220	230	240
GSGAASSSGE	DKENDGFVFK	MPWKPTHPSS	THALAEWASR	REAFAQRPSS	APDLMCLSPD
250	260	270	280	290	300
RKMEVEELSP	LALGRFSLTP	AEGDTEEDDG	FVDILESDLK	DDDAVPPGME	SLISAPLVKT
310	320	330	340	350	360
LEKEEEKDLV	MYSKCQRLFR	SPSMPCSVIR	PILKRLERPQ	DRDTPVQNKR	RRSVTPPEEQ
370	380	390	400	410	420
QEAEEPKARV	LRSKSLCHDE	IENLLDSDHR	ELIGDYSKAF	LLQTVDGKHQ	DLKYISPETM
430	440	450	460	470	480
VALLTGKFSN	IVDKFVIVDC	RYPYEYEGGH	IKTAVNLPLE	RDAESFLLKS	PIAPCSLDKR
490	500	510	520	530	540
VILIFHCEFS	SERGPRMCRF	IRERDRAVND	YPSLYYPEMY	ILKGGYKEFF	PQHPNFCEPQ
550	560	570
DYRPMNHEAF	KDELKTFRLK	TRSWAGERSR	RELCSRLQDQ