P23913

PR
Gene name
LBR
Protein name
Delta(14)-sterol reductase LBR
Names
Delta-14-SR, 3-beta-hydroxysterol Delta (14)-reductase, C-14 sterol reductase, C14SR, Integral nuclear envelope inner membrane protein, Lamin-B receptor, Sterol C14-reductase
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:396285
EC number
1.3.1.70: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

35-158 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P23913

Entry ID Method Resolution Chain Position Source
2L8D NMR - A 1-62 PDB
AF-P23913-F1 Predicted AlphaFoldDB

No variants for P23913

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P23913

No associated diseases with P23913

6 regional properties for P23913

Type Name Position InterPro Accession
domain Helicase, C-terminal 540 - 735 IPR001650
conserved_site DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site 468 - 477 IPR002464
domain Helicase-associated domain 756 - 846 IPR007502
domain DEAD/DEAH box helicase domain 357 - 511 IPR011545
domain DEAD-box helicase, OB fold 903 - 980 IPR011709
domain Helicase superfamily 1/2, ATP-binding domain 348 - 535 IPR014001

Functions

Description
EC Number 1.3.1.70 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Nucleus inner membrane ; Multi-pass membrane protein
  • Nucleus
  • Cytoplasm
  • Endoplasmic reticulum membrane
  • Nucleus; nuclear rim
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
nuclear inner membrane The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
delta14-sterol reductase activity Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
NADPH binding Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions.
oxidoreductase activity, acting on the CH-CH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

3 GO annotations of biological process

Name Definition
cholesterol biosynthetic process The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
neutrophil differentiation The process in which a myeloid precursor cell acquires the specialized features of a neutrophil.
sterol biosynthetic process The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

6 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9J5 DHCR7 7-dehydrocholesterol reductase Bos taurus (Bovine) PR
Q9UBM7 DHCR7 7-dehydrocholesterol reductase Homo sapiens (Human) PR
Q14739 LBR Delta(14)-sterol reductase LBR Homo sapiens (Human) PR
Q3U9G9 Lbr Delta(14)-sterol reductase LBR Mus musculus (Mouse) PR
O08984 Lbr Delta(14)-sterol reductase LBR Rattus norvegicus (Rat) PR
Q6P4M0 dhcr7 7-dehydrocholesterol reductase Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) PR
10 20 30 40 50 60
MPNRKYADGE VVMGRWPGSV LYYEVQVTSY DDASHLYTVK YKDGTELALK ESDIRLQSSF
70 80 90 100 110 120
KQRKSQSSSS SPSRRSRSRS RSRSPGRPAK GRRRSSSHSR EHKEDKKKII QETSLAPPKP
130 140 150 160 170 180
SENNTRRYNG EPDSTERNDT SSKLLEQQKL KPDVEMERVL DQYSLRSRRE EKKKEEIYAE
190 200 210 220 230 240
KKIFEAIKTP EKPSSKTKEL EFGGRFGTFM LMFFLPATVL YLVLMCKQDD PSLMNFPPLP
250 260 270 280 290 300
ALESLWETKV FGVFLLWFFF QALFYLLPIG KVVEGLPLSN PRKLQYRING FYAFLLTAAA
310 320 330 340 350 360
IGTLLYFQFE LHYLYDHFVQ FAVSAAAFSM ALSIYLYIRS LKAPEEDLAP GGNSGYLVYD
370 380 390 400 410 420
FFTGHELNPR IGSFDLKYFC ELRPGLIGWV VINLAMLLAE MKIHNQSMPS LSMILVNSFQ
430 440 450 460 470 480
LLYVVDALWN EEAVLTTMDI THDGFGFMLA FGDLVWVPFV YSLQAFYLVG HPIAISWPVA
490 500 510 520 530 540
AAITILNCIG YYIFRSANSQ KNNFRRNPAD PKLSYLKVIP TATGKGLLVT GWWGFVRHPN
550 560 570 580 590 600
YLGDIIMALA WSLPCGFNHI LPYFYVIYFI CLLVHREARD EHHCKKKYGL AWERYCQRVP
610 620 630
YTHISLHLLE HSTYLICKLK YTSHLCTWSV CYLGFKH