Q5E9J5
PR
Gene name |
DHCR7 |
Protein name |
7-dehydrocholesterol reductase |
Names |
7-DHC reductase, Sterol Delta(7)-reductase |
Species |
Bos taurus (Bovine) |
KEGG Pathway |
bta:514745 |
EC number |
1.3.1.21: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5E9J5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5E9J5-F1 | Predicted | AlphaFoldDB |
161 variants for Q5E9J5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs380374263 | 8 | S>N | No | EVA | |
| rs133829546 | 35 | V>A | No | EVA | |
| rs133829546 | 35 | V>G | No | EVA | |
| rs447218980 | 36 | D>G | No | EVA | |
| rs478643002 | 37 | W>R | No | EVA | |
| rs461669126 | 38 | F>V | No | EVA | |
| rs462499676 | 44 | I>M | No | EVA | |
| rs439342229 | 47 | L>V | No | EVA | |
| rs440255854 | 57 | F>S | No | EVA | |
| rs474931185 | 59 | M>V | No | EVA | |
| rs454816496 | 62 | D>A | No | EVA | |
| rs438007221 | 63 | Q>* | No | EVA | |
| rs475895012 | 63 | Q>P | No | EVA | |
| rs452654319 | 65 | G>C | No | EVA | |
| rs432539812 | 66 | C>W | No | EVA | |
| rs467206095 | 67 | S>Y | No | EVA | |
| rs447073877 | 68 | L>P | No | EVA | |
| rs447073877 | 68 | L>Q | No | EVA | |
| rs468114797 | 69 | T>I | No | EVA | |
| rs482698869 | 70 | V>M | No | EVA | |
| rs462481456 | 71 | P>A | No | EVA | |
| rs474878197 | 74 | D>E | No | EVA | |
| rs440213905 | 74 | D>G | No | EVA | |
| rs444366595 | 76 | A>P | No | EVA | |
| rs475843180 | 77 | T>P | No | EVA | |
| rs475843180 | 77 | T>S | No | EVA | |
| rs432404777 | 78 | G>W | No | EVA | |
| rs473495545 | 79 | R>G | No | EVA | |
| rs453500608 | 80 | A>G | No | EVA | |
| rs468031265 | 82 | L>F | No | EVA | |
| rs468031265 | 82 | L>I | No | EVA | |
| rs209363888 | 83 | A>P | No | EVA | |
| rs209363888 | 83 | A>T | No | EVA | |
| rs445610589 | 84 | D>A | No | EVA | |
| rs468765904 | 84 | D>H | No | EVA | |
| rs476881734 | 85 | I>N | No | EVA | |
| rs476881734 | 85 | I>T | No | EVA | |
| rs481292865 | 88 | R>G | No | EVA | |
| rs461198916 | 88 | R>S | No | EVA | |
| rs444359583 | 89 | T>A | No | EVA | |
| rs458882653 | 92 | V>A | No | EVA | |
| rs458882653 | 92 | V>G | No | EVA | |
| rs438844564 | 93 | T>S | No | EVA | |
| rs473458860 | 96 | A>S | No | EVA | |
| rs442994196 | 97 | A>G | No | EVA | |
| rs453414815 | 97 | A>T | No | EVA | |
| rs474462991 | 98 | Q>E | No | EVA | |
| rs437413105 | 98 | Q>H | No | EVA | |
| rs457477271 | 98 | Q>P | No | EVA | |
| rs465521815 | 99 | I>M | No | EVA | |
| rs451959399 | 100 | Y>F | No | EVA | |
| rs431990501 | 101 | T>S | No | EVA | |
| rs481264501 | 103 | W>C | No | EVA | |
| rs467548402 | 104 | V>G | No | EVA | |
| rs450599761 | 107 | Q>* | No | EVA | |
| rs436987055 | 127 | G>W | No | EVA | |
| rs465121961 | 128 | G>R | No | EVA | |
| rs468714037 | 155 | H>P | No | EVA | |
| rs448566488 | 155 | H>Q | No | EVA | |
| rs526904577 | 166 | G>A | No | EVA | |
| rs209298247 | 166 | G>S | No | EVA | |
| rs469669374 | 200 | Y>S | No | EVA | |
| rs446397865 | 204 | T>P | No | EVA | |
| rs466097317 | 216 | F>C | No | EVA | |
| rs455557392 | 220 | M>R | No | EVA | |
| rs468305539 | 235 | F>I | No | EVA | |
| rs435581432 | 272 | L>F | No | EVA | |
| rs384087243 | 275 | I>V | No | EVA | |
| rs450137908 | 277 | Q>P | No | EVA | |
| rs478480417 | 287 | N>K | No | EVA | |
| rs481667680 | 294 | T>A | No | EVA | |
| rs481667680 | 294 | T>P | No | EVA | |
| rs876503317 | 301 | H>P | No | EVA | |
| rs797229130 | 312 | V>I | No | EVA | |
| rs441039725 | 323 | L>M | No | EVA | |
| rs455557462 | 324 | Y>S | No | EVA | |
| rs441998412 | 326 | V>A | No | EVA | |
| rs441998412 | 326 | V>G | No | EVA | |
| rs476729148 | 328 | H>D | No | EVA | |
| rs456659940 | 328 | H>L | No | EVA | |
| rs464721674 | 330 | V>A | No | EVA | |
| rs434235350 | 342 | L>R | No | EVA | |
| rs468905933 | 344 | G>V | No | EVA | |
| rs448897350 | 345 | L>M | No | EVA | |
| rs480286336 | 345 | L>R | No | EVA | |
| rs469772088 | 353 | M>I | No | EVA | |
| rs477978333 | 359 | D>A | No | EVA | |
| rs449716989 | 359 | D>Y | No | EVA | |
| rs457744126 | 360 | L>V | No | EVA | |
| rs478690706 | 361 | F>L | No | EVA | |
| rs441001235 | 361 | F>V | No | EVA | |
| rs461926997 | 365 | D>E | No | EVA | |
| rs441959787 | 371 | W>G | No | EVA | |
| rs476602225 | 375 | P>A | No | EVA | |
| rs476602225 | 375 | P>T | No | EVA | |
| rs456474830 | 378 | I>F | No | EVA | |
| rs439656784 | 379 | E>G | No | EVA | |
| rs471091462 | 380 | C>R | No | EVA | |
| rs454307948 | 380 | C>S | No | EVA | |
| rs434212712 | 381 | S>P | No | EVA | |
| rs468858672 | 384 | S>P | No | EVA | |
| rs455183806 | 386 | D>A | No | EVA | |
| rs438283908 | 386 | D>E | No | EVA | |
| rs455183806 | 386 | D>G | No | EVA | |
| rs379586024 | 387 | G>R | No | EVA | |
| rs477927783 | 388 | Q>K | No | EVA | |
| rs464118323 | 389 | R>K | No | EVA | |
| rs447398056 | 389 | R>S | No | EVA | |
| rs464118323 | 389 | R>T | No | EVA | |
| rs478654262 | 390 | H>D | No | EVA | |
| rs461786164 | 390 | H>P | No | EVA | |
| rs448322327 | 391 | H>P | No | EVA | |
| rs483015927 | 392 | S>G | No | EVA | |
| rs439625210 | 392 | S>R | No | EVA | |
| rs462926914 | 392 | S>T | No | EVA | |
| rs471066055 | 393 | K>R | No | EVA | |
| rs471066055 | 393 | K>T | No | EVA | |
| rs475150575 | 395 | L>P | No | EVA | |
| rs475150575 | 395 | L>R | No | EVA | |
| rs438252195 | 396 | V>A | No | EVA | |
| rs455145252 | 396 | V>F | No | EVA | |
| rs476138169 | 397 | S>A | No | EVA | |
| rs476138169 | 397 | S>P | No | EVA | |
| rs456090251 | 397 | S>W | No | EVA | |
| rs432824083 | 398 | G>V | No | EVA | |
| rs433655134 | 399 | F>L | No | EVA | |
| rs447264403 | 399 | F>V | No | EVA | |
| rs468181078 | 400 | W>G | No | EVA | |
| rs468181078 | 400 | W>R | No | EVA | |
| rs448204033 | 401 | G>A | No | EVA | |
| rs462839782 | 402 | V>A | No | EVA | |
| rs462839782 | 402 | V>G | No | EVA | |
| rs477356831 | 403 | A>P | No | EVA | |
| rs440504710 | 405 | H>D | No | EVA | |
| rs475115805 | 405 | H>P | No | EVA | |
| rs461539168 | 406 | F>Y | No | EVA | |
| rs444619773 | 407 | N>D | No | EVA | |
| rs476144783 | 415 | S>N | No | EVA | |
| rs432677750 | 418 | Y>F | No | EVA | |
| rs470363214 | 422 | C>Y | No | EVA | |
| rs468144165 | 426 | H>L | No | EVA | |
| rs468144165 | 426 | H>P | No | EVA | |
| rs433620219 | 426 | H>Y | No | EVA | |
| rs448248344 | 430 | Y>S | No | EVA | |
| rs437835766 | 438 | I>V | No | EVA | |
| rs445844550 | 441 | T>P | No | EVA | |
| rs477317935 | 442 | H>N | No | EVA | |
| rs466931914 | 442 | H>P | No | EVA | |
| rs461454113 | 449 | H>P | No | EVA | |
| rs444616770 | 450 | R>H | No | EVA | |
| rs482439699 | 452 | A>D | No | EVA | |
| rs459149750 | 454 | K>R | No | EVA | |
| rs453568741 | 455 | Y>* | No | EVA | |
| rs473519025 | 455 | Y>C | No | EVA | |
| rs439033825 | 455 | Y>D | No | EVA | |
| rs798108225 | 457 | R>H | No | EVA | |
| rs474722640 | 458 | D>G | No | EVA | |
| rs527024933 | 461 | H>R | No | EVA | |
| rs454499263 | 464 | A>T | No | EVA | |
| rs437694268 | 465 | A>P | No | EVA | |
| rs432231070 | 476 | F>Q | No | EVA |
No associated diseases with Q5E9J5
2 regional properties for Q5E9J5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Sterol reductase, conserved site | 213 - 228 | IPR018083-1 |
| conserved_site | Sterol reductase, conserved site | 439 - 462 | IPR018083-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.1.21 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 7-dehydrocholesterol reductase activity | Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+. |
| NADP binding | Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. |
| oxidoreductase activity, acting on the CH-CH group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| sterol delta7 reductase activity | Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| brassinosteroid biosynthetic process | The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. |
| cholesterol biosynthetic process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P23913 | LBR | Delta(14)-sterol reductase LBR | Gallus gallus (Chicken) | PR |
| Q14739 | LBR | Delta(14)-sterol reductase LBR | Homo sapiens (Human) | PR |
| Q9UBM7 | DHCR7 | 7-dehydrocholesterol reductase | Homo sapiens (Human) | PR |
| Q3U9G9 | Lbr | Delta(14)-sterol reductase LBR | Mus musculus (Mouse) | PR |
| Q6P4M0 | dhcr7 | 7-dehydrocholesterol reductase | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAKSQPSAP | KTKSTSGLTN | GNAAAQGQWG | RAWEVDWFSL | ASVIFLLLFA | PFIVYYFIMA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| CDQYGCSLTV | PVADLATGRA | RLADIWARTP | PVTAKAAQIY | TAWVTLQVLL | YMLLPDFCHK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| FLPGYVGGVQ | EGAVTPAGAV | NKYEINGLQA | WLLTHLLWFA | NAHLLGWFSP | TIIFDNWIPL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LWCANILGYT | VSTFAMVKGY | LFPTDARECK | FTGNFFYNYM | MGVEFNPRIG | KWFDFKLFFN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GRPGIVAWTL | INLSFAAKQQ | ELYGHVTNSM | VLVNILQAIY | VLDFFWNETW | YLKTIDICHD |
| 310 | 320 | 330 | 340 | 350 | 360 |
| HFGWYLGWGD | CVWLPYLYTL | QGLYLVYHPV | QLPTYYALGV | LLLGLLGYYI | FRMTNHQKDL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| FRRTDGRCLI | WGRKPKAIEC | SYTSADGQRH | HSKLLVSGFW | GVARHFNYTG | DLMGSLAYCL |
| 430 | 440 | 450 | 460 | 470 | |
| ACGGGHLLPY | FYIIFMAILL | THRCLRDEHR | CANKYGRDWE | HYTAAVPYRL | LPGIF |