Q6P4M0
Gene name |
dhcr7 |
Protein name |
7-dehydrocholesterol reductase |
Names |
7-DHC reductase, Sterol Delta(7)-reductase |
Species |
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
KEGG Pathway |
xtr:394844 |
EC number |
1.3.1.21: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q6P4M0
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q6P4M0-F1 | Predicted | AlphaFoldDB |
No variants for Q6P4M0
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q6P4M0 | |||||
No associated diseases with Q6P4M0
6 regional properties for Q6P4M0
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Coagulation factor 5/8 C-terminal domain | 272 - 422 | IPR000421-1 |
| domain | Coagulation factor 5/8 C-terminal domain | 428 - 581 | IPR000421-2 |
| domain | CUB domain | 25 - 139 | IPR000859-1 |
| domain | CUB domain | 145 - 263 | IPR000859-2 |
| domain | MAM domain | 639 - 811 | IPR000998 |
| domain | Neuropilin, C-terminal | 847 - 923 | IPR022579 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.1.21 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of endoplasmic reticulum membrane | The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 7-dehydrocholesterol reductase activity | Catalysis of the reaction: cholesterol + NADP+ = cholesta-5,7-dien-3-beta-ol + NADPH + H+. |
| NADP binding | Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. |
| oxidoreductase activity, acting on the CH-CH group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
| sterol delta7 reductase activity | Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| brassinosteroid biosynthetic process | The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects. |
| cholesterol biosynthetic process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5E9J5 | DHCR7 | 7-dehydrocholesterol reductase | Bos taurus (Bovine) | PR |
| P23913 | LBR | Delta(14)-sterol reductase LBR | Gallus gallus (Chicken) | PR |
| Q14739 | LBR | Delta(14)-sterol reductase LBR | Homo sapiens (Human) | PR |
| Q9UBM7 | DHCR7 | 7-dehydrocholesterol reductase | Homo sapiens (Human) | PR |
| Q3U9G9 | Lbr | Delta(14)-sterol reductase LBR | Mus musculus (Mouse) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGERRRANAS | RGDKKVANGE | KPHVGQWGRA | WEVDYFSLAA | VLFLLAFAPL | IVYYFVMSCD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QYQCALTAPV | LDLYWGKAQL | SDIWDKTPAL | TWGAAKIYIV | WVSFQVFLYM | LVPDILHKFV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PGYEGGVQEG | ARTPAGLINK | YQVNGLQAWT | ITHLLWFANA | YHFHWFSPTI | IIDNWVPLLW |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CANLLGYSVA | TFALLKAYFF | PTNAHDCKFT | GNFFYDYMMG | IEFNPRIGKW | FDFKLFFNGR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PGIVAWTLIN | LSYAAKQQEL | YGQVTNSMIL | VNVLQAIYVV | DFFWNESWYL | KTIDICHDHF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| GWYLGWGDCV | WLPYLYTLQG | LYLVYNPVEL | STATAVGVLL | LGLIGYYIFR | MTNHQKDLFR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RTNGNCKIWG | KKPKSIECSY | TSADGKRHYS | KLMISGFWGV | ARHLNYTGDL | MGSLAYCLAC |
| 430 | 440 | 450 | 460 | 470 | |
| GFDHLLPYFY | FTYMTILLVH | RCIRDEHRCS | SKYGKDWKLY | TDAVPYRLLP | GLF |