O08984
PR
Gene name |
Lbr |
Protein name |
Delta(14)-sterol reductase LBR |
Names |
Delta-14-SR, 3-beta-hydroxysterol Delta (14)-reductase, C-14 sterol reductase, C14SR, Integral nuclear envelope inner membrane protein, Lamin-B receptor, NBP60, Sterol C14-reductase |
Species |
Rattus norvegicus (Rat) |
KEGG Pathway |
rno:89789 |
EC number |
1.3.1.70: With NAD(+) or NADP(+) as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for O08984
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-O08984-F1 | Predicted | AlphaFoldDB |
No variants for O08984
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for O08984 | |||||
No associated diseases with O08984
11 regional properties for O08984
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | C2 domain | 402 - 524 | IPR000008-1 |
| domain | C2 domain | 560 - 693 | IPR000008-2 |
| domain | Synaptotagmin | 564 - 579 | IPR001565-1 |
| domain | Synaptotagmin | 579 - 592 | IPR001565-2 |
| domain | Synaptotagmin | 636 - 651 | IPR001565-3 |
| domain | Synaptotagmin | 656 - 666 | IPR001565-4 |
| domain | Rab-binding domain | 44 - 161 | IPR010911 |
| domain | Zinc finger, FYVE-related | 92 - 149 | IPR017455 |
| domain | Rabphilin-3A, FYVE domain | 92 - 172 | IPR028698 |
| domain | FYVE-type zinc finger | 49 - 161 | IPR041282 |
| domain | Rabphilin/Doc2, first C2 domain | 403 - 526 | IPR047022 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.3.1.70 | With NAD(+) or NADP(+) as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nuclear envelope | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). |
| nuclear inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope. |
| nuclear membrane | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. |
| nuclear pore | A protein complex providing a discrete opening in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
7 GO annotations of molecular function
| Name | Definition |
|---|---|
| chaperone binding | Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. |
| chromo shadow domain binding | Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain. |
| delta14-sterol reductase activity | Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| NADPH binding | Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. |
| nuclear localization sequence binding | Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. |
| oxidoreductase activity, acting on the CH-CH group of donors | Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| cholesterol biosynthetic process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| neutrophil differentiation | The process in which a myeloid precursor cell acquires the specialized features of a neutrophil. |
| sterol biosynthetic process | The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPGRKFADGE | VVRGRWPGSS | LYYEVEILSH | DSTSQLYTVK | YKDGTELELK | ESDIKPLKSF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KQRKSGSTSS | SPSRRRSSRS | RSRSRSRSPG | RAPKGSRRSV | SASYQADAKE | KEMRREILQV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KLTPLVLKPF | ANSVSVYNGE | PEHMEKSATP | PKNKQERVIL | STEDSYIATQ | YSLRPRREEV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KPKHRVRGTN | LVTRGPVPLG | TFQVTTPQRR | DLEFGGVPGA | LLIMLGLPAC | VFLLLLQCAQ |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KDPGLLQFPP | PLPALRELWE | ARVCGVYLLW | FFLQALFSLL | PVGKVVEGTP | LVDGRRLKYR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LNGLYAFILT | SAAVGTAVFW | DIELYYLYTH | FLQFALAAIV | FSVVLSVYLY | ARSLKVPRDE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LSPASSGNAV | YDFFIGRELN | PRIGAFDLKF | FCELRPGLIG | WVVINLVMLL | AEMKVQERSA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PSLAMTLVNS | FQLLYVVDAL | WFEEALLTTM | DIIHDGFGFM | LAFGDLVWVP | FTYSLQAFYL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| VNHPQDLSWP | LTSVIIALKL | CGYVIFRCAN | SQKNAFRKNP | TDPKLAHLKT | IPTSTWKSLL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VSGWWGFVRH | PNYLGDLIMA | LAWSLPCGFN | HILPYFYVIY | FTALLIHREA | RDEHQCRRKY |
| 610 | |||||
| GLAWEKYCQR | VPYRIFPYIY |