O76511

PR
Gene name
Ts (CG3181)
Protein name
Thymidylate synthase
Names
TS, TSase
Species
Drosophila melanogaster (Fruit fly)
KEGG Pathway
dme:Dmel_CG3181
EC number
2.1.1.45: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for O76511

Entry ID Method Resolution Chain Position Source
AF-O76511-F1 Predicted AlphaFoldDB

No variants for O76511

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for O76511

No associated diseases with O76511

2 regional properties for O76511

Type Name Position InterPro Accession
active_site Thymidylate synthase, active site 181 - 209 IPR020940
domain Thymidylate synthase/dCMP hydroxymethylase domain 38 - 321 IPR023451

Functions

Description
EC Number 2.1.1.45 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
thymidylate synthase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate.

3 GO annotations of biological process

Name Definition
dTMP biosynthetic process The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate).
dTTP biosynthetic process The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate.
methylation The process in which a methyl group is covalently attached to a molecule.

5 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P04818 TYMS Thymidylate synthase Homo sapiens (Human) PR
O81395 DRTS Bifunctional dihydrofolate reductase-thymidylate synthase Zea mays (Maize) PR
P07607 Tyms Thymidylate synthase Mus musculus (Mouse) PR
P45352 Tyms Thymidylate synthase Rattus norvegicus (Rat) PR
Q05763 THY-2 Bifunctional dihydrofolate reductase-thymidylate synthase 2 Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MVLTPTKDGP DQESMPLPAD NGESPSKQQA PVNRDEMHYL DLLRHIIANG EQRMDRTEVG
70 80 90 100 110 120
TLSVFGSQMR FDMRNSFPLL TTKRVFFRAV AEELLWFVAG KTDAKLLQAK NVHIWDGNSS
130 140 150 160 170 180
REFLDKMGFT GRAVGDLGPV YGFQWRHFGA QYGTCDDDYS GKGIDQLRQV IDTIRNNPSD
190 200 210 220 230 240
RRIIMSAWNP LDIPKMALPP CHCLAQFYVS EKRGELSCQL YQRSADMGLG VPFNIASYAL
250 260 270 280 290 300
LTHMIAHVTG LKPGDFVHTM GDTHVYLNHV EPLKEQLERT PRPFPKLIIK RQVQDIEDFR
310 320
FEDFQIVDYN PHPKIQMDMA V