I3LM39

PR
Gene name
CGAS
Protein name
Cyclic GMP-AMP synthase
Names
cGAMP synthase, cGAS, 2'3'-cGAMP synthase, Mab-21 domain-containing protein 1
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:100516408
EC number
2.7.7.86: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-111 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for I3LM39

Entry ID Method Resolution Chain Position Source
4JLX X-ray 200 A A 135-495 PDB
4JLZ X-ray 227 A A/B 135-495 PDB
4KB6 X-ray 308 A A 135-495 PDB
AF-I3LM39-F1 Predicted AlphaFoldDB

20 variants for I3LM39

Variant ID(s) Position Change Description Diseaes Association Provenance
rs318619902 33 V>M No EVA
rs329876422 146 V>M No EVA
rs786794866 195 I>M No EVA
rs788779841 197 A>V No EVA
rs791062183 213 Q>* No EVA
rs786427434 216 E>* No EVA
rs1108095582 217 Y>* No EVA
rs1112881417 219 N>S No EVA
rs792889127 221 G>C No EVA
rs789657607 223 H>Y No EVA
rs343170829 226 V>I No EVA
rs789456234 233 G>A No EVA
rs790072955 234 G>R No EVA
rs787263573 239 Q>K No EVA
rs699926976 245 I>M No EVA
rs709803265 249 S>A No EVA
rs699590799 267 E>K No EVA
rs699573509 316 S>R No EVA
rs710441953 380 C>G No EVA
rs80867491 473 K>E No EVA

No associated diseases with I3LM39

2 regional properties for I3LM39

Type Name Position InterPro Accession
domain Mab-21-like, nucleotidyltransferase domain 189 - 364 IPR046903
domain Mab-21-like, HhH/H2TH-like domain 380 - 484 IPR046906

Functions

Description
EC Number 2.7.7.86 Nucleotidyltransferases
Subcellular Localization
  • Nucleus
  • Chromosome
  • Cell membrane ; Peripheral membrane protein
  • Cytoplasm, cytosol
  • Mainly localizes in the nucleus, and at low level in the cytosol (By similarity)
  • On chromosomes, enriched on centromeric satellite and LINE DNA repeat elements
  • Exported from the nucleus to the cytosol in a XPO1/CRM1 via the nuclear export signal in response to DNA stimulation (By similarity)
  • Outside the nucleus, localizes at the cell membrane as a peripheral membrane protein in resting conditions: association to the cell membrane is mediated via binding to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) (By similarity)
  • Localization at the cell membrane is required to limit the recognition of self-DNA
  • Following detection of double-stranded DNA (dsDNA), released from the cell membrane into the cytosol in order to signal
  • Upon transfection with dsDNA forms punctate structures that co-localize with DNA and Beclin-1 (BECN1)
  • Phosphorylation at Tyr-190 promotes cytosolic retention
  • In response to translation stress, translocates to the cytosol and associates with collided ribosomes (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

No GO annotations of biological process

Name Definition
No GO annotations for biological process

4 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
E1BGN7 CGAS Cyclic GMP-AMP synthase Bos taurus (Bovine) PR
Q8N884 CGAS Cyclic GMP-AMP synthase Homo sapiens (Human) PR
Q8C525 Mb21d2 Nucleotidyltransferase MB21D2 Mus musculus (Mouse) PR
Q8C6L5 Cgas Cyclic GMP-AMP synthase Mus musculus (Mouse) PR
10 20 30 40 50 60
MAARRGKSTR TASEVGAAGP RASARSVNGA PTVPEAARPG ARRNGPSRAS GCRREKSGPD
70 80 90 100 110 120
PREKPQVRTR TARAEDQAEG PSAPSERVEP PSAQGASLLR AGSCRAREAR SARELRPQAG
130 140 150 160 170 180
ATELAAPARM EAPPGAWKLQ TVLEKVRLSR HEISEAAEVV NWVVEHLLRR LQGGESEFKG
190 200 210 220 230 240
VALLRTGSYY ERVKISAPNE FDVMFKLEVP RIQLEEYCNS GAHYFVKFKR NPGGNPLEQF
250 260 270 280 290 300
LEKEILSASK MLSKFRKIIK EEIKNIEGVT VERKRRGSPA VTLLISKPKE ISVDIILALE
310 320 330 340 350 360
SKSSWPASTQ KGLPISQWLG AKVKNNLKRQ PFYLVPKHAK EGSGFQEETW RLSFSHIEKD
370 380 390 400 410 420
ILKNHGQSKT CCEIDGVKCC RKECLKLMKY LLEQLKKKFG NRRELAKFCS YHVKTAFFHV
430 440 450 460 470 480
CTQDPHDNQW HLKNLECCFD NCVAYFLQCL KTEQLANYFI PGVNLFSRDL IDKPSKEFLS
490
KQIEYERNNG FPVFW