Q9ZNT1
Gene name |
CBR1 |
Protein name |
NADH--cytochrome b5 reductase 1 |
Names |
|
Species |
Arabidopsis thaliana (Mouse-ear cress) |
KEGG Pathway |
ath:AT5G17770 |
EC number |
1.6.2.2: With a heme protein as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q9ZNT1
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q9ZNT1-F1 | Predicted | AlphaFoldDB |
12 variants for Q9ZNT1
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| ENSVATH10814888 | 31 | F>I | No | 1000Genomes | |
| tmp_5_5865782_C_T | 108 | D>N | No | 1000Genomes | |
| ENSVATH06984438 | 127 | H>Y | No | 1000Genomes | |
| ENSVATH10814804 | 135 | D>G | No | 1000Genomes | |
| ENSVATH06984430 | 184 | K>N | No | 1000Genomes | |
| ENSVATH00628035 | 184 | K>T | No | 1000Genomes | |
| ENSVATH00628033 | 193 | T>I | No | 1000Genomes | |
| ENSVATH06984424 | 202 | E>G | No | 1000Genomes | |
| ENSVATH10814801 | 229 | G>A | No | 1000Genomes | |
| tmp_5_5864849_A_G | 248 | S>P | No | 1000Genomes | |
| ENSVATH00628031 | 249 | D>E | No | 1000Genomes | |
| tmp_5_5864566_G_A | 275 | P>S | No | 1000Genomes |
No associated diseases with Q9ZNT1
7 regional properties for Q9ZNT1
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Receptor, ligand binding region | 68 - 471 | IPR001828 |
| domain | GPCR, family 3, nine cysteines domain | 507 - 557 | IPR011500 |
| domain | GPCR family 3, C-terminal | 573 - 840 | IPR017978 |
| conserved_site | GPCR, family 3, conserved site | 157 - 175 | IPR017979-1 |
| conserved_site | GPCR, family 3, conserved site | 529 - 551 | IPR017979-2 |
| conserved_site | GPCR, family 3, conserved site | 767 - 777 | IPR017979-3 |
| domain | Metabotropic glutamate receptor, Homer-binding domain | 1153 - 1203 | IPR019588 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.6.2.2 | With a heme protein as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| mitochondrial outer membrane | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. |
| plant-type cell wall | A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances. |
| plastid | Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cytochrome-b5 reductase activity, acting on NAD(P)H | Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| electron transport chain | A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. |
5 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3MHW9 | CYB5R1 | NADH-cytochrome b5 reductase 1 | Bos taurus (Bovine) | PR |
| Q96HP4 | OXNAD1 | Oxidoreductase NAD-binding domain-containing protein 1 | Homo sapiens (Human) | PR |
| Q9UHQ9 | CYB5R1 | NADH-cytochrome b5 reductase 1 | Homo sapiens (Human) | PR |
| Q9DB73 | Cyb5r1 | NADH-cytochrome b5 reductase 1 | Mus musculus (Mouse) | PR |
| Q5EB81 | Cyb5r1 | NADH-cytochrome b5 reductase 1 | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDTEFLRTLD | RQILLGVFVA | FVAVGAGAAY | FLTSSKKRRV | CLDPENFKEF | KLVKRHQLSH |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NVAKFVFELP | TSTSVLGLPI | GQHISCRGKD | GQGEDVIKPY | TPTTLDSDVG | RFELVIKMYP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| QGRMSHHFRE | MRVGDHLAVK | GPKGRFKYQP | GQFRAFGMLA | GGSGITPMFQ | VARAILENPT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DKTKVHLIYA | NVTYDDILLK | EELEGLTTNY | PEQFKIFYVL | NQPPEVWDGG | VGFVSKEMIQ |
| 250 | 260 | 270 | 280 | ||
| THCPAPASDI | QILRCGPPPM | NKAMAANLEA | LGYSPEMQFQ | F |